DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Grm1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_058707.2	Gene:	Grm1 / 24414	RGDID:	2742	Length:	1199	Species:	Rattus norvegicus

Alignment Length:	1384	Identity:	270/1384 - (19%)
Similarity:	449/1384 - (32%)	Gaps:	465/1384 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPD-------------- 170
            :::.||....||.....|.:|    .:.|..|.:::..||  |....|..:
  Rat    16 MSILPRMPDRKVLLAGASSQR----SVARMDGDVIIGALF--SVHHQPPAEKVPERKCGEIREQY 74

  Fly   171 GLSELGAATMAVEHINRKR-LLPGYTLELVTNDTQC----------------------DPGVGVD 212
            |:..:.|....::.||... |||..||.....|: |                      |...|::
  Rat    75 GIQRVEAMFHTLDKINADPVLLPNITLGSEIRDS-CWHSSVALEQSIEFIRDSLISIRDEKDGLN 138

  Fly   213 RFFHAIYTQPSTR----MVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYR 273
            |......|.|..|    :..::|...|.|...:..::..::|.|:::.:||..|||:..:.||.|
  Rat   139 RCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLR 203

  Fly   274 TVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKE 338
            .|..|:....|.:..::::.| |..:....|..:..:..:...||.|....|.|......::..|
  Rat   204 VVPSDTLQARAMLDIVKRYNW-TYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGE 267

  Fly   339 QLL--LLRETDTRI----IIGSFSQELAPQILCEAYR-------LRMFGADYAWI---------- 380
            :..  |||:...|:    ::..|.:.:..:.|..|.|       ..:.|:| .|.
  Rat   268 KSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSD-GWADRDEVIEGYE 331

  Fly   381 ---------------------------LHESMGAPWWPD--------------------QRTACS 398
                                       |..:...||:|:                    ::....
  Rat   332 VEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTG 396

  Fly   399 NHELQLAVENLIVVSTHNSIVGNNVSYS---GLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISI 460
            |..|:   ||.:..|....::  |..|:   ||.|        ...|...|..|        :..
  Rat   397 NESLE---ENYVQDSKMGFVI--NAIYAMAHGLQN--------MHHALCPGHVG--------LCD 440

  Fly   461 AATQSDSRRRR----RRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSK 521
            |....|.|:..    :....|.||..::.:.... ||..||.:                |.:.::
  Rat   441 AMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGD-APGRYDIM----------------NLQYTE 488

  Fly   522 LDGFDYTRSDMAW--------EFLQQMGKLHFL-GVSGPVSFSGPDRVGTTAFYQIQRGLLEPVA 577
            .:.:||.... .|        ::..||.|...: .|.......|..:|       |::|   .|:
  Rat   489 ANRYDYVHVG-TWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKV-------IRKG---EVS 542

  Fly   578 LYYPATDAL-------DFRCPRCRPVKWHSGQV----PIAKRVFKLR-VATIAPLAFYTIATLSS 630
            ..:..|...       :|.|..|....|.:.::    ||..|..:.. :.:|..:||      |.
  Rat   543 CCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAF------SC 601

  Fly   631 VGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVC 695
            :||.:.:......:.:|....:|.||.:|..|...|....|.....|....:|         |.|
  Rat   602 LGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTT---------TSC 657

  Fly   696 TARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGS-----VFKDKMLQDIQLILLVGGLLLVD-AL 754
            ..:..|:....::.:.::..||.|:.||.  .||     ..|.:.:.....:::...|:.|. .|
  Rat   658 YLQRLLVGLSSAMCYSALVTKTNRIARIL--AGSKKKICTRKPRFMSAWAQVIIASILISVQLTL 720

  Fly   755 LVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE----VCRSQHTQTWLSVL--YAYKGLLLV 813
            :|||.::..||                .::..|.::    :|.:.:    |.|:  ..|.|||::
  Rat   721 VVTLIIMEPPM----------------PILSYPSIKEVYLICNTSN----LGVVAPVGYNGLLIM 765

  Fly   814 VGVYMAWETRHVKIPA-LNDSQYIGVSVYSV-VITSAIVVVLANLISERVTLAFITITALILTST 876
            ...|.|::||:|  || .|:::||..::|:. :|..|.|.:......:.:|..|    |:.|:.|
  Rat   766 SCTYYAFKTRNV--PANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCF----AVSLSVT 824

  Fly   877 TATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQA 941
            .|..| :|.||::.|.|              |.|.|.|
  Rat   825 VALGC-MFTPKMYIIIA--------------KPERNVR--------------------------- 847

  Fly   942 LDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILP 1006
                              ::.|||....:..|.|.|             |..|
  Rat   848 ------------------SAFTTSDVVRMHVGDGKL-------------PCRS------------ 869

  Fly  1007 NLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLEEACLPAQDLINLRLA-HQQATEA--- 1067
            |..|::.....|.|...::.      .:||:: |:|...:|  |....:..||: |.:..|.
  Rat   870 NTFLNIFRRKKPGAGNANSN------GKSVSW-SEPGGRQA--PKGQHVWQRLSVHVKTNETACN 925

  Fly  1068 KTGLINRLRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNPNQD 1132
            :|.:|..|       |.|.:||..||                      :...||...:||...:|
  Rat   926 QTAVIKPL-------TKSYQGSGKSL----------------------TFSDASTKTLYNVEEED 961

  Fly  1133 SIPSEASSHPNGNHLKPIHRGSLTKSGTHL-DHLTKD--PNFLPIPTISGG------EQGDQTLG 1188
            :.||...|.|:...:....||....:...| .|||.:  |.||....|..|      :|..|
  Rat   962 NTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQ--- 1023

  Fly  1189 GKYVKLLETKVNFQLPSNRRPSVVQQPPSLRERVR--------GSPRFPHRIL------------ 1233
                         |.|..:.|   |||.||.::::        |.|.| |.:|
  Rat  1024 -------------QPPPQQPP---QQPKSLMDQLQGVVTNFGSGIPDF-HAVLAGPGTPGNSLRS 1071

  Fly  1234 -----PPTCSLSAL--------AESEDRPGDSTSILGSCKSIPRISLQQ----ATSGGTWKSMET 1281
                 ||...|..|        .||...||:...     ....|..|.|    ...|.|.:
  Rat  1072 LYPPPPPPQHLQMLPLHLSTFQEESISPPGEDDD-----DDSERFKLLQEFVYEREGNTEE---- 1127

  Fly  1282 AGKSRLSLGDSQEEEQQAP 1300
                     |..|||:..|
  Rat  1128 ---------DELEEEEDLP 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	99/566 (17%)
		ANF_receptor	174..568	CDD:279440	89/506 (18%)
		7tm_3	633..889	CDD:278433	62/269 (23%)
Grm1	NP_058707.2	PBP1_mGluR_groupI	36..510	CDD:380597	91/521 (17%)
		Glutamate binding	186..188		0/1 (0%)
		NCD3G	521..571	CDD:400103	10/59 (17%)
		7tmC_mGluR1	591..840	CDD:320565	68/292 (23%)
		TM helix 1	592..616	CDD:320565	6/29 (21%)
		TM helix 2	628..649	CDD:320565	4/20 (20%)
		TM helix 3	658..680	CDD:320565	2/21 (10%)
		TM helix 4	708..724	CDD:320565	4/15 (27%)
		TM helix 5	749..772	CDD:320565	7/26 (27%)
		TM helix 6	784..806	CDD:320565	6/21 (29%)
		TM helix 7	809..834	CDD:320565	8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..905		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..1036		24/95 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1081		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1177		7/31 (23%)
		GluR_Homer-bdg	1150..1199	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910