DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Gpr156

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_700443.2	Gene:	Gpr156 / 239845	MGIID:	2653880	Length:	798	Species:	Mus musculus

Alignment Length:	807	Identity:	185/807 - (22%)
Similarity:	310/807 - (38%)	Gaps:	192/807 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 IAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDH 681
            ::|.....:.|..|.|:.|.:.||||.:..||.:.:|:|||.|:.:|.:|....|.:..|.|:..
Mouse    45 LSPALLGIMWTFLSCGLLLVLFFLAFTIRCRKNRIVKMSSPNLNVVTLLGSCLTYISAYLFGIQD 109

  Fly   682 STLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDK--MLQDIQLILL 744
            :...|   |...:...|:.||..|.||.||.:..|::|::::||:.   ..||  :::|:||:.|
Mouse   110 ALEGS---SVEALIQTRLSLLCIGTSLVFGPILGKSWRLYKVFTQR---VPDKRVIIKDLQLLGL 168

  Fly   745 VGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQ-PQVEVCRSQHTQTWLSVLYAYK 808
            |..|::.|.:|:..||:|||:: .|..|.:.:..|.|.|... .....|.|:::..|::::...|
Mouse   169 VAALVVADVILLVTWVLTDPIQ-CLQMLGVSMKVTGRDVSCSLTNTHFCASRYSDVWIALVLGCK 232

  Fly   809 GLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALIL 873
            ||||:.|.|:|..|.||..|.:|.|..|.|.|..:::|:.::.|:...:.....|.|...:..|.
Mouse   233 GLLLLYGAYLAGLTNHVSSPPVNQSLTIMVGVNLLLLTAGLLFVVTRYLHSWPNLVFGLTSGGIF 297

  Fly   874 TSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRF-----------VVDDRRELQYR 927
            ..||...|.:|||:|.. |...:..:..:..|.......::.|           :.|::..::..
Mouse   298 VCTTTVNCCVFIPQLKQ-WKAFEGENQTMRHMAKYFSTPSKSFHGQFDEDPSCHLRDEKSCMERL 361

  Fly   928 VEVQNRVYKKEIQALDAEI----RKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTS--- 985
            :..:|.|    |::|..::    .||.:|:.:..|..|                 ||..|..
Mouse   362 LTEKNAV----IESLQEQVSNAKEKLVKLMSAECTYDS-----------------PEWAVPDAAS 405

  Fly   986 -------GISQTPAASKNRTPSISGILPNLLLSVL--------PPVIPRASWPS-AEYMQIPMRR 1034
                   |.|:.||.|:|.    ||......|.|.        |....|.:.|| |:...:|:::
Mouse   406 ARGLALPGPSECPAVSENE----SGAAARDSLHVPAACQHVQGPGASRRDTSPSPAQQDNMPLKQ 466

  Fly  1035 SV----TFASQ-PQLE----------EACLPAQDLI--NLRLAHQQATEAKTGLINRLRGIFSRT 1082
            ..    |..:| |:.|          |...|:|.|:  .:.....:..::..||..:|.|:.|..
Mouse   467 YCDHLDTGCNQKPKAEQSEGPERGDQEPMAPSQRLMADGVACEPHKPRQSPEGLPKKLPGVSSVV 531

  Fly  1083 TSS--------NKGSTASLADQKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNP---NQDSIPS 1136
            ...        :.||.|.|:.....:..:||...      .|.|..|.:.:..:|   .:.....
Mouse   532 REKLQEVLQELDLGSEAPLSPLPCPQQLWKSTTS------RSPQKLSPSKLGFSPYVVRRRRAAQ 590

  Fly  1137 EASSH-PNGNHLKPIHRGSLTKSGT------------HLDH------LTKDPNFLPIP------- 1175
            .|.|| |....|...|:.:.|.|.:            .|||      :.:..:..|.|
Mouse   591 RARSHIPGSVGLNVGHQANSTVSSSQSGLIVQNRDSPRLDHNNARSKVPRSSSVKPSPLSEPRRK 655

  Fly  1176 --TISGGEQGD---QTLGGKYVKLLETKVNFQLPSNRRPSVVQQPPSL-------------RERV 1222
              |:.|.:|.:   |..||        ..|...|.....||..|.|:.             :.|.
Mouse   656 QGTLEGSKQCETEPQEAGG--------ACNVAFPCQSSASVQAQSPAAPCLPSSPALPRQRQPRP 712

  Fly  1223 RGSPRFP-----------------------HRILPPTCSLSALAESEDRPGDSTSILGSCKSIPR 1264
            |.||..|                       ||.....|..|:|..::....||
Mouse   713 RLSPGCPSLSSGCYNLDSESSSSDEFFCRCHRPYCEICFQSSLDSNDSDTSDS------------ 765

  Fly  1265 ISLQQATSGGTWKSMETAGKSRLSLGD 1291
             .|:||:...:|..:....|..::..|
Mouse   766 -DLEQASGLASWGKLWARSKPVVNFKD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361
		ANF_receptor	174..568	CDD:279440
		7tm_3	633..889	CDD:278433	82/258 (32%)
Gpr156	NP_700443.2	7tm_3	71..>141	CDD:278433	22/72 (31%)
		rad18	347..>538	CDD:273165	42/215 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..497		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..666		25/125 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..715		3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810