DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and Vmn2r102

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001098034.1 Gene:Vmn2r102 / 224572 MGIID:3647786 Length:857 Species:Mus musculus


Alignment Length:851 Identity:163/851 - (19%)
Similarity:292/851 - (34%) Gaps:233/851 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 AATMAVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPST---------------- 224
            |...|:|.|||. .|||..:|             |.| |::..:|:..|                
Mouse    84 ALQFAIEEINRNPNLLPNTSL-------------GFD-FYNVRFTEKYTLDNAFIWLTALVNRKY 134

  Fly   225 --------RMVMLLGSACSEVTES-LAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSS 280
                    |......:..|.:|.: :..::..:...|::||...|.|||..::|..|:....|:|
Mouse   135 FPNYNCKKRNFTAALTGTSWITSAQIGTLLQLFKFPQITFGPYDPLLSDHGQYPSLYQMAPKDTS 199

  Fly   281 HNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCA------ATITFAATDFKEQ 339
            .:.|.::.|..|.|..|.....::...:..|::...|:|...|..|      ||.|.....|.|.
Mouse   200 LSLAIVSLIAHFRWSWVGLILPDDHKGNKIVSDFREEMERKGICLAFVKMIPATWTSHFAKFWEH 264

  Fly   340 LLLLRETDTRIIIG----------SFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQR 394
               :.||:..|:.|          :..|.|..|              ..||::            
Mouse   265 ---MDETNVTIVYGDVDSLEGVIRNIEQRLLTQ--------------NVWIMN------------ 300

  Fly   395 TACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQD----------- 448
              ..:|.:..| :..::.:.|.|::   ..:|...|..|...::..:.:.:.:|           
Mouse   301 --IEHHVIDRA-DYFMLDTFHGSLI---FKHSYRENFEFTKFIKTVNPKKYPEDIYLPKLWHLFF 359

  Fly   449 --GFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALAL---RA 508
              .|.....:.:....|.:......|         |:|..|:::.:...|:.|:|:|.:|   |.
Mouse   360 KCSFADINCNVLDNCQTNASLDVFPR---------HIFDVAMNEESSSIYNGVYAVAHSLHEMRL 415

  Fly   509 AEEH--------------WRRNE-----EQSKLDGFDYTRS-DMAWEFLQQMGKLHFLGVS---G 550
            .|..              |:.|.     |.......|:.:: |..::.|........||:.   |
Mouse   416 QELQMQPYENGKGIVFFPWQLNRFLKDTEVKDKRCLDWKQTIDTEYDILNLWNLPKGLGLKVKIG 480

  Fly   551 PVSFSGPDRVGTTAFYQIQRGLLEPVALYYP----------ATDALD--FR----------CPRC 593
            ..|.:.|         |.|:..|....:.:|          .:::.:  ||          |.:|
Mouse   481 SFSANAP---------QGQQLSLSEQMIQWPEIFSEIPQSVCSESCEPGFRKVTLEGKAICCYKC 536

  Fly   594 RP---------------VKWHSGQVPIAKR--VFKLRVATIA---PLAFYTIATLSSVGI---AL 635
            .|               ||...|.....:|  .|:..|..:|   ||..    .|:|:.:   :|
Mouse   537 TPCGDNEISNETDVYQCVKCPEGHFANTERNNCFQKSVIFLAYEDPLGM----ALASIALCLSSL 597

  Fly   636 AIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVY 700
            .:..:...:..|....:|.::..||.|..:...|.:    |..|:....|:     ...|..:..
Mouse   598 TVFVIGIFVKHRDTPIVKANNRALSYILLLTLTFCF----LCSLNFIGQPN-----TATCILQQT 653

  Fly   701 LLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI----LLVGGLLLVDALLVTLWVV 761
            ..:..|::|..::.||...|...|..:   |..|:::.:.|.    .::....|:..|:..:|:.
Mouse   654 TFAVTFTMALATVLAKAITVVLAFKVS---FPGKIVRWLMLSRGPNYIIPICTLIQLLICGIWMA 715

  Fly   762 TDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLL--LVVGVY-MAWETR 823
            |.|          .....|....|...:.:|.......:.|||    |.|  |.:|.| ||:.:|
Mouse   716 TSP----------PFIDEDAHTEYGQIIILCNKGSAVAFHSVL----GYLCFLALGSYTMAFLSR 766

  Fly   824 HVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKL 888
            ::. ...|:|:|:..|:  :|.....|..|....|.:..:........||.|:||.|..:|.||.
Mouse   767 NLP-DTFNESKYLSFSM--LVFFCVWVTFLPVYHSTKGKIMVAMEVFSILASSTALLAFIFGPKC 828

  Fly   889 HDIWAR 894
            :.|..|
Mouse   829 YIILLR 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 96/540 (18%)
7tmC_GABA-B-like 621..892 CDD:320175 58/280 (21%)
TM helix 1 621..645 CDD:320175 3/26 (12%)
TM helix 2 657..678 CDD:320175 5/20 (25%)
TM helix 3 696..720 CDD:320175 4/23 (17%)
TM helix 4 741..761 CDD:320175 4/23 (17%)
TM helix 5 797..823 CDD:320175 10/28 (36%)
TM helix 6 832..855 CDD:320175 6/22 (27%)
TM helix 7 862..887 CDD:320175 7/24 (29%)
Vmn2r102NP_001098034.1 PBP1_pheromone_receptor 42..501 CDD:380588 88/483 (18%)
NCD3G 509..560 CDD:462210 7/50 (14%)
7tmC_V2R_pheromone 582..833 CDD:320410 61/283 (22%)
TM helix 1 582..607 CDD:320410 5/28 (18%)
TM helix 2 619..640 CDD:320410 6/24 (25%)
TM helix 3 649..673 CDD:320410 4/23 (17%)
TM helix 4 697..713 CDD:320410 2/15 (13%)
TM helix 5 740..766 CDD:320410 10/29 (34%)
TM helix 6 774..797 CDD:320410 6/24 (25%)
TM helix 7 802..827 CDD:320410 7/24 (29%)

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