Protein Alignment GABA-B-R3 and Vmn2r104

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001098036.1
• Gene: Vmn2r104 / 22313
• MGIID: 1316665
• Length: 860
• Species: Mus musculus
• Alignment Length: 865
• Identity: 162/865 - (18%)
• Similarity: 301/865 - (34%)
• Gaps: 261/865 - (30%)

  Fly   177 AATMAVEHINRK-RLLPGYTLELVTNDTQCDPGVGVDRFFHAIYTQPS------------TRMVM 228
            |...|:|.|||. .:||..:|             |.| |::..||:.:            .:..|
Mouse    87 ALLFAIEEINRNPNILPNISL-------------GFD-FYNNEYTERNILRFTCRWLTAHVKRAM 137

  Fly   229 LLGSAC------------SEVTES-LAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSS 280
            :....|            |.:|.: :..::..:...|::||...|.|||..::...|:....|:|
Mouse   138 IPNYTCKRRNVIAALTGSSWITSAQIGTLLQLFKFPQITFGPYEPTLSDDGQYSSLYQMAPKDTS 202

  Fly   281 HNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCA------ATITFAATDFKEQ 339
            .:.|.::|:..|.|..:.....:....:..::....|:|...|..|      ||.|...|.|.|.
Mouse   203 LSLAIVSFMVHFSWSWIGLIIPDNHKGNKILSEFREEMERNKICIAFLKMIPATWTSYFTRFWEN 267

  Fly   340 LLLLRETDTRIIIGSF-SQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQ 403
               :.||:..||.|.. |.|:..||:  ..||..:.   .||::.              ..|.::
Mouse   268 ---MDETNVIIIYGDIDSLEILMQII--GQRLLTWN---IWIMNN--------------EPHIIE 310

  Fly   404 LAVENLIVVSTHNSIV-----GNNV------------------------------SYSGLNNHMF 433
            |: :..::.|.|.|.:     .:|:                              |:|.:|.|:.
Mouse   311 LS-DYFMLDSFHGSFIFRHNYRDNIEFTKFIQRVNPYKYPEDIYLPKLWNFFFKCSFSDINCHVL 374

  Fly   434 NSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDA 498
            ::  .|.:|.......|                                :|...:|:.:...|:.
Mouse   375 DN--CKTNASLDLLPSF--------------------------------IFDVVMSEESTNIYNG 405

  Fly   499 VWAIA----------LALRAAEE-------HWRRN------EEQSKLDGFDYTRS-DMAWEFLQQ 539
            |:|:|          |.::|.|.       .|:.|      |.:.|.: .|:.:: |..::.|..
Mouse   406 VYALAHSLHQMRLQLLQMQAFENGEEMVFFPWQLNTFLKDIEVKDKRN-LDWKQTIDTEYDILNL 469

  Fly   540 MGKLHFLGVS---GPVSFSGPDRVGTTAFYQIQRGLLEPVALYYP-------------------- 581
            ......||:.   |..|.:.|         |.|:..|....:.:|
Mouse   470 WNLPKGLGLKVKIGSFSANAP---------QGQQLSLSEQIIQWPEIFSEVPQSVCSESCRPGFR 525

  Fly   582 --ATDALDFRCPRCRPVKWH--SGQVPIAKRV---------------FKLRVATIA---PLAFYT 624
              :.|.....|.:|.|...:  |.:..:.:.|               |...|:.:|   ||..
Mouse   526 KVSLDDKAICCYKCTPCADNEISNETDVDQCVKCPESHYANTEKSNCFPKSVSFLAYEDPLGM-- 588

  Fly   625 IATLSSVGI---ALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPS 686
              .|:|:.:   ||.:..:...:..|....:|.::..||.|..:...|.:    |..|:....|:
Mouse   589 --ALASIALCLSALTVFVIGIFVKNRDTPIVKANNRTLSYILLITLTFCF----LCSLNFIGQPN 647

  Fly   687 AEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLI----LLVGG 747
                 ...|..:....:..|::|..::.||...|...|..:   |..:||:.:.:.    .::..
Mouse   648 -----TAACILQQTTFAVAFTMALATVLAKAITVVLAFKIS---FPGRMLRWLMISRGPRYIIPI 704

  Fly   748 LLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLL- 811
            ..|:..||..:|:.|.|     ..:..:::..|..::.     :|.......:.|||    |.|
Mouse   705 CTLIQLLLCGIWMATSP-----PFIDQDVNTEDGYIIL-----LCNKGSAVAFHSVL----GYLC 755

  Fly   812 -LVVGVY-MAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILT 874
             |.:|.| ||:.:|::. ...|:|:::..|:..........:.:.:....:|.:|....:  ||.
Mouse   756 FLALGSYTMAFLSRNLP-DTFNESKFLSFSMLVFFCVWVTFLPVYHSTKGKVMVAMEVFS--ILA 817

  Fly   875 STTATLCLLFIPKLHDIWAR 894
            |:||.|..:|.||.:.|..|
Mouse   818 SSTALLAFIFGPKCYIILLR 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	97/541 (18%)
		7tmC_GABA-B-like	621..892	CDD:320175	56/280 (20%)
		TM helix 1	621..645	CDD:320175	4/26 (15%)
		TM helix 2	657..678	CDD:320175	5/20 (25%)
		TM helix 3	696..720	CDD:320175	4/23 (17%)
		TM helix 4	741..761	CDD:320175	4/23 (17%)
		TM helix 5	797..823	CDD:320175	10/28 (36%)
		TM helix 6	832..855	CDD:320175	2/22 (9%)
		TM helix 7	862..887	CDD:320175	8/24 (33%)
Vmn2r104	NP_001098036.1	PBP1_pheromone_receptor	45..504	CDD:380588	92/497 (19%)
		NCD3G	512..565	CDD:462210	6/52 (12%)
		7tmC_V2R_pheromone	585..836	CDD:320410	59/283 (21%)
		TM helix 1	585..610	CDD:320410	6/28 (21%)
		TM helix 2	622..643	CDD:320410	6/24 (25%)
		TM helix 3	652..676	CDD:320410	4/23 (17%)
		TM helix 4	700..716	CDD:320410	3/15 (20%)
		TM helix 5	743..769	CDD:320410	10/29 (34%)
		TM helix 6	777..800	CDD:320410	2/22 (9%)
		TM helix 7	805..830	CDD:320410	9/26 (35%)