Protein Alignment GABA-B-R3 and gcy-14

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_506660.2
• Gene: gcy-14 / 191647
• WormBaseID: WBGene00001540
• Length: 1111
• Species: Caenorhabditis elegans
• Alignment Length: 592
• Identity: 109/592 - (18%)
• Similarity: 184/592 - (31%)
• Gaps: 189/592 - (31%)

  Fly   158 LFELSTSRGPRPDGLSELGAATM-AVEHINRKRLLPGYTLELVTNDTQCDPGVG----VDRFFHA 217
            ||...|:...|..|.....||.: |.:.|..:.||..|.........:|..|:.    |:...|
 Worm    25 LFSKDTASVMRAVGYRTSAAAVLVARDRIRAEHLLDQYDFNFTVKFDECTEGLAGGKTVELINH- 88

  Fly   218 IYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPA-LSDRREFPYFYRTVAPDSSH 281
                  ..:.:::|..|:....::|.:..|:|:....:|.|:.| :.:...:|... |::.| :|
 Worm    89 ------DNVDVIIGPTCNRAGIAVASLAAYYNVPVFQWGLTTAADIGNVSRYPTTV-TLSLD-TH 145

  Fly   282 NPAR--IAFIRKFGWGTVTTF-----------SQNEEVHSLAVNN-------------------- 313
            :.|.  ...:|:|.|......           |..:::..:.:.|
 Worm   146 SMALGVREVLRRFEWDEFVFIYSNDGDEEKCASMKDDLEKMGIENSDVTLAYMVQIQTVTLDALQ 210

  Fly   314 -LVTELEAAN---ISC-----------AATITFAATDFKEQLLLLRETDTRIII----------- 352
             .:||:....   |:|           .|:...|.....|.:.:..|..:|...
 Worm   211 KALTEVSKRGRIIIACFANGRGFKKAFVASTVLAGMSTDEYMYMFAEPQSRGFYVDEINGGEHYS 275

  Fly   353 -----GSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENL--- 409
                 |:|...|.|:.:.:||...::..|       :||.|.......|  |...|| :..:
 Worm   276 WDDTDGNFVTGLTPEQIRDAYGKVLYICD-------NMGLPTTITPEFA--NFSSQL-ISRMTEQ 330

  Fly   410 ---IVVSTHNSIVGNNVSYSG------------LNNHMFNSQLRK--QSAQFHGQD------GFG 451
               .|....||......:|:|            ||..:.....|.  ::..|...|      |.|
 Worm   331 PFNCVQDCSNSTYKVPATYAGQLFDAFYAYGVALNRSLTQDPTRANLKNGSFVLSDIGMSFQGVG 395

  Fly   452 SG------YGSRI------------------SIAATQSD--------------SRRRRRRGVGGT 478
            .|      .|:||                  |:....|:              |.|...|.:.|.
 Worm   396 GGTVTLDDTGTRIVQVYMFALNTSLLPYLAASLVINGSEVEYTPFYKSEADLWSVRPLARPICGF 460

  Fly   479 SGGHLFPEAISQYAPQTYDAVWAIALALRAA------EEHWRRNEEQSKLDGFDYTRSDMAWEF- 536
            ||....|:.:.:|...|..|...:.|||.|.      ....:|.|.:         |.|:.|:.
 Worm   461 SGLECPPDFVKEYLVYTIIAAVIVVLALLAGCAGLLYTMQMKRKEME---------RQDLLWQVP 516

  Fly   537 ---LQQM-------GKLHFLGVSGP-----VSFSGPDRVGTTAFYQIQRGLL----EPVALYYPA 582
               |||:       ..:|.. .|||     ::...........||..|:.:|    ..:.|.:.|
 Worm   517 FIELQQVQSKSKAEASMHSF-ASGPSTSTKITVESRSETINFIFYYYQQDILAAMKHDLILQFDA 580

  Fly   583 TDALDFR 589
            ....:||
 Worm   581 EQKAEFR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	109/592 (18%)
		ANF_receptor	174..568	CDD:279440	98/549 (18%)
		7tm_3	633..889	CDD:278433
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347	73/416 (18%)
		ANF_receptor	43..418	CDD:279440	68/393 (17%)
		PKc_like	535..800	CDD:304357	11/54 (20%)
		HNOBA	<817..860	CDD:285003
		CYCc	839..1031	CDD:214485
		Guanylate_cyc	866..1053	CDD:278633

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910