DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and gbb-2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_500579.3	Gene:	gbb-2 / 191240	WormBaseID:	WBGene00022675	Length:	842	Species:	Caenorhabditis elegans

Alignment Length:	934	Identity:	278/934 - (29%)
Similarity:	436/934 - (46%)	Gaps:	165/934 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 FESERRMSPAEMQRNHGKIVL-LGLFELSTSRGPRPDGLSELGAATMAVEHI-NRKRLLPGYTLE 197
            :|:...:|   .:|.||.|.| ||:|  :..:...||.|.   |...|:.|: :|..:|.||.||
Worm    18 YEAGEELS---CKRRHGGIPLPLGVF--TVQKEGFPDALP---AIRTALSHVHSRSCILQGYRLE 74

  Fly   198 LVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSP-- 260
            ::..||.|....|:...|..|.::|  |.|.:||..|:||.|.:|..:.||.|||:|:..|..
Worm    75 MIVKDTHCKTSQGMKALFDLIASRP--RPVAILGGQCTEVNEPIAMALKYWQIVQLSYAETHAKF 137

  Fly   261 ALSDRRE-FPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEV-HSLAVNNLVTELE-AAN 322
            |.||..| |..|:|.|....:.|.|:..|:..|||..|.|..||::. ::|....|.|.|| ...
Worm   138 ASSDSHELFTTFFRVVPGSRNTNMAKCKFVNHFGWKRVGTVKQNDQPRYALPHEALTTRLEHGFG 202

  Fly   323 ISCAATITFAATDFKE------QLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWIL 381
            :....|   |..::::      :|..|:|.|.|||:....:|:|..:||..|...|:|.:|.|||
Worm   203 VKIVHT---AGVNWEQIETVGGELDELKERDVRIILVDVDEEMAATVLCAGYHRGMYGDNYVWIL 264

  Fly   382 HESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHG 446
            .......|.......|:..|::.|.:|      |.|
Worm   265 PGYHSDKWLNQTHDNCTVEEMREAAKN------HFS----------------------------- 294

  Fly   447 QDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQT------YDAVWAIALA 505
                       :..|.|:.|...:.   ||.|..|.::.| |:|..|..      ||.:|.:|:|
Worm   295 -----------VEFALTRRDVDTKI---VGNTRAGDVWNE-ITQLDPNNTWRGYLYDGLWTLAIA 344

  Fly   506 LRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQR 570
            |           ..|..|..:::...|    ::.:....|.|::|.|.|:..:|:|.....|...
Worm   345 L-----------SHSMGDNAEFSHHKM----MEAIDNSSFQGLTGKVKFANNERLGLVDIKQWSD 394

  Fly   571 GLLEPVALYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIAL 635
            |...|.|:|..|.|  :|:........|   ..|:...:.:.|...|:.:.|..::.|:.:||.|
Worm   395 GQYVPFAVYDGADD--EFKIIDSTTKGW---SPPLDSTITERRREHISSILFLAMSLLALIGIFL 454

  Fly   636 AIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVY 700
            |:.||..|..:|..:.||:|||.|:||...|.|..:|:||:||||  |...:.|.|..:|..:.:
Worm   455 ALIFLLINFRYRNHRFIKMSSPNLNNIIIAGSICTFASVIMLGLD--TRIVSPDVFVWLCYTKTW 517

  Fly   701 LLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKD-KMLQDIQLILLVGGLLLVDALLVTLWVVTDP 764
            .|..||:|:||:||:||:|||.|||   ::..| |.::|.:|.:::|.||.:|..::..|....|
Worm   518 TLCIGFTLSFGAMFSKTWRVHSIFT---NIRMDRKAIKDSKLFIILGILLFIDICVLVTWAFVSP 579

  Fly   765 MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA 829
            ..   :.:|......:.::|..|:||.|.|.|:..:.:||||.||:|:::|.::|||||||.:||
Worm   580 FS---YTVTELPHIPEDNIVIIPEVEKCNSSHSGVFQAVLYAVKGVLMILGCFLAWETRHVNVPA 641

  Fly   830 LNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWAR 894
            ||||:|||.|||..|:.|.:.:..:.::.|||...|...:..::.|||.||||:|:||:.:: ||
Worm   642 LNDSKYIGTSVYCCVVMSVLGLSTSVILQERVNEMFSLASFFVIFSTTLTLCLVFVPKVIEL-AR 705

  Fly   895 NDI-IDPVIHSMGL----------KMECNTRRFVVDDRRELQYRVEVQNR-----VYKKEIQALD 943
            |.: .:|..:..||          .|....|.   |...:|..:.|.:|:     :::|..|..|
Worm   706 NPVGNEPRAYRRGLMKSVVAKTSQPMSPQPRS---DSSGDLIGKAESENKLRRRYLHQKSTQLWD 767

  Fly   944 AEIRKLE-----RLLESGLTTTSTTTSS---STSLLTGGGHLKPELTVTSGISQTPAASKNR-TP 999
            . :.||.     |.|:.....:|.:.||   .||||.                :.|::|.|| ..
Worm   768 L-VEKLRAQGDTRFLQQEWCLSSASPSSQERETSLLL----------------RQPSSSNNREET 815

  Fly  1000 SISGILPNLLLSVLPPVIPRASWP 1023
            |::...||...|        :.||
Worm   816 SLTAAGPNGERS--------SDWP 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	122/450 (27%)
		ANF_receptor	174..568	CDD:279440	109/411 (27%)
		7tm_3	633..889	CDD:278433	105/256 (41%)
gbb-2	NP_500579.3	PBP1_GABAb_receptor	50..395	CDD:107361	111/417 (27%)
		7tmC_GABA-B-R2	439..705	CDD:320421	108/274 (39%)
		TM helix 1	439..464	CDD:320421	9/24 (38%)
		TM helix 2	476..497	CDD:320421	9/20 (45%)
		TM helix 3	513..537	CDD:320421	10/23 (43%)
		TM helix 4	556..576	CDD:320421	6/19 (32%)
		TM helix 5	609..635	CDD:320421	11/25 (44%)
		TM helix 6	644..667	CDD:320421	10/22 (45%)
		TM helix 7	674..699	CDD:320421	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D267884at33208
OrthoFinder	1	1.000	-	-		FOG0005571
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820