Protein Alignment GABA-B-R3 and F35H10.10

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_501400.1
• Gene: F35H10.10 / 177627
• WormBaseID: WBGene00018073
• Length: 1404
• Species: Caenorhabditis elegans
• Alignment Length: 1100
• Identity: 204/1100 - (18%)
• Similarity: 351/1100 - (31%)
• Gaps: 374/1100 - (34%)

  Fly    56 SISTSSPSSSPPGESASTVTAGGTPIPPRSDWKYKRTKVKRRQQRLNS--------HSNLPGSTN 112
            :|...:....|......:.|.|..|....|       .::...|||.|        ....|....
 Worm   458 AIEIYNQDKEPVTSRLLSFTTGNPPTVIMS-------SLRSADQRLRSICAPYRPFCGQCPNLQI 515

  Fly   113 ASHAHHLLNLPPRQRYLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRPDGLSELGA 177
            .:..||.|::|                         .|..:.|:|||:|.:            |.
 Worm   516 VNSDHHFLSIP-------------------------RHYPLYLVGLFDLHS------------GQ 543

  Fly   178 ATMAVEHINRKRLLPGYTLELVTNDTQCDPGVGV--DRFFHAIYTQPSTRMVMLLGSACSEVTES 240
            ...::.|.:..  ||...:..|....|..|.:|:  |..|.|           ||..:||...::
 Worm   544 TCQSMAHTDIS--LPMAFVHTVWTFKQRFPQLGLLKDLDFGA-----------LLIDSCSSGKQA 595

  Fly   241 LAKVV-----------PYWNIVQVS---FGSTSPALSDRREF--PYF------YRTVAPDSSHNP 283
            :..||           ...||..|.   ||..|....|.:|.  .||      ...|:.||.|:.
 Worm   596 IESVVRSETQCFRFNQAGRNITIVPKSVFGYASALHGDSQESLKGYFSSGDTDASLVSVDSEHSA 660

  Fly   284 ARIAF----------------IRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFA 332
            .:.:|                :.:..|..||.....::..||::......|......|.|.:...
 Worm   661 LQRSFTALPSSRNQALALLKLLNRMQWQFVTAALSEQDPESLSLFRAFERLALDRGVCLAEVLNI 725

  Fly   333 ATDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLR------MFGADYAWILHESMGAPWWP 391
            .   ..:|..:|.|....|:.|.:::.|..::  |.::|      |.|..:.|.||    ||
 Worm   726 G---GSRLDNIRSTTNVTIVFSTARDAADYLI--ASKIRGNHVNVMMGEAHDWYLH----AP--- 778

  Fly   392 DQRTACSNHELQLAVENLIVVSTHNSIVGN--------------NVSYSGLNNHMFNSQLRKQSA 442
                  :|.||   ....:.|...|.:.|:              .:.|.......:...|.::|.
 Worm   779 ------NNKEL---FPGTVSVQPRNILYGDFREWLETTTPLTLPELWYWSYIESRYGCALSQKSK 834

  Fly   443 QFHGQ----------DGFG----SGYGSR-------------ISIAATQS--------DSRRRRR 472
            ..:|:          :..|    :||.||             .|:...|:        ..||:..
 Worm   835 VIYGKMCTGDELLNIESLGRMTKAGYLSRGVERFLFAMDSVYKSLCPAQNGLCLEFYEQGRRQIL 899

  Fly   473 RGVGGTSGG------HLFPEAISQYAPQTYDAV--WAIALALRAAEEHWRRN--EEQSK------ 521
            ..:..||..      ...|:..:.:   ||..:  |.:...||...::...|  ..:||
 Worm   900 TQLKKTSTEDDVEIYEFLPDINNHF---TYHLIANWTLTTGLRMTNQYRNGNGVPTESKCQPPMC 961

  Fly   522 ---LDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVS---FSGPDRVGTTAFYQIQRGLLEPVALYY 580
               |||          :|.|:           |:.   |...:..|:.....|:|         .
 Worm   962 KCFLDG----------DFFQR-----------PLDSFVFRPDEPEGSDQSSYIKR---------Q 996

  Fly   581 PA--TDALDFRCP---------RCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIA 634
            ||  ::.::::..         |..|   |:                      |.:..|.:|.:.
 Worm   997 PAFGSEKIEYQSVFEHITTGHWRDHP---HN----------------------YVLLALITVLVV 1036

  Fly   635 LAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARV 699
            :|||.|...|....|:.:| .:..|.....:|.|.:|:|......|.:      ||   ||..||
 Worm  1037 VAIAVLVLVLVKLYLRVVK-GNQSLGISLLIGIIILYSTAFFFVFDPT------DS---VCRLRV 1091

  Fly   700 YLLSAGFSLAFGSMFAKTYRVHRIFT-RTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTD 763
            .|...|:::.||.|.||..::....| ..|:...........|:..:.|:.:  ||.:: |.:..
 Worm  1092 ILHGLGYTICFGVMIAKATQLRNAETLGFGTAIHISFWNYWLLLFFIVGVQI--ALSIS-WFLEP 1153

  Fly   764 PMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP 828
            .|.        .|...|.:|    |..:|.....:..:|..|..  :|:.:.::::...|::| .
 Worm  1154 FMS--------TIGVIDTNV----QRMMCTMGKVEFVVSNFYVM--ILIFMALFISMLNRNIK-R 1203

  Fly   829 ALNDSQYIGVSVYSVVIT-------SAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIP 886
            ...:::::   :||.|:.       ..:.:||.:...:.|.:..:...|.||      |..||.|
 Worm  1204 NYKETKWL---LYSTVLCFFTWVAWITLYLVLDHEFRDTVIVVELVACATIL------LGFLFGP 1259

  Fly   887 KLHDIWARNDII-----DPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEI 946
            |::.:.:...::     ||..:        :|..|..||....|..|.
 Worm  1260 KIYILLSYEPVVVAFKRDPFPN--------HTDLFEKDDDLPSQRAVS----------------- 1299

  Fly   947 RKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILP 1006
                       ..:||::||:.|              :||.|.|  :|..|..:..|.||
 Worm  1300 -----------PASSTSSSSNRS--------------SSGSSYT--SSSKRPVNAVGPLP 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	101/551 (18%)
		ANF_receptor	174..568	CDD:279440	93/510 (18%)
		7tm_3	633..889	CDD:278433	58/263 (22%)
F35H10.10	NP_501400.1	PBP1_GPCR_family_C-like	57..354	CDD:380573
		PBP1_GPCR_family_C-like	532..809	CDD:380573	66/322 (20%)
		7tm_classC_mGluR-like	<1072..1266	CDD:320091	48/229 (21%)
		TM helix 3	1088..1112	CDD:320091	9/23 (39%)
		TM helix 4	1131..1150	CDD:320091	4/21 (19%)
		TM helix 5	1173..1199	CDD:320091	3/27 (11%)
		TM helix 6	1207..1230	CDD:320091	3/25 (12%)
		TM helix 7	1237..1260	CDD:320091	7/28 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910