DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and mgl-3

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001076735.3	Gene:	mgl-3 / 177327	WormBaseID:	WBGene00021152	Length:	1008	Species:	Caenorhabditis elegans

Alignment Length:	1018	Identity:	201/1018 - (19%)
Similarity:	332/1018 - (32%)	Gaps:	319/1018 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLFEL---------STSRGPRPDGLSELGAATMAVEHINRKR-LLP------------- 192
            |:|||.|||.:         ...:.....|:..:.|...|:|.:||.| |||
Worm    43 GQIVLGGLFPIHEAGRNASHQCGKIKADQGVQRMVAMLFALEKVNRDRQLLPQASLGAQILDTCS 107

  Fly   193 --GY----TLELVTNDTQCDPGVGVDRFFHAIYT-QPSTRMVMLLGSACSEVTESLAKVVPYWNI 250
              .|    |||.:.:......||.........|| ||   :|.::|:|.|:|:..:|.::..:.|
Worm   108 VDSYALEQTLEFIKSVMSNGDGVTCADGSTGSYTRQP---VVAVVGAAGSQVSVMVASMLQLFKI 169

  Fly   251 VQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV 315
            .|||:.||...||::..|.:|.|.|.||:.........|....|    |:     ||::|.....
Worm   170 PQVSYSSTGAELSEKPRFAFFSRVVPPDNLQAQVMARVIGALEW----TY-----VHAIADTGSY 225

  Fly   316 TELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWI 380
            .|....:...||.......|...|.:..|.|:...          ..:|...:|.|
Worm   226 GERGMDSFRAAAAENGICIDGDVQKISRRWTEKNF----------RDLLIRMHRTR--------- 271

  Fly   381 LHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFH 445
              ::.|...:.|:    .|.:..|...:|:|...|..          |:.|.:          |.
Worm   272 --KARGVVMFVDE----DNLKRLLKTLDLLVAEGHTE----------LDRHFW----------FV 310

  Fly   446 GQDGFG-----------SGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAI----------- 488
            ..|.:|           ..||: |:||....:...........:..|.:|.|..
Worm   311 ASDSWGIKQSVVRGLEHRTYGA-ITIAPMVREETGYLEYFRSLSPKGFVFLEEFFEYLGCSATVD 374

  Fly   489 -----------------SQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYT--RSDMAW 534
                             ..|.|...|.|..||.|:....|     ::..|:.....|  :|....
Worm   375 VKTFGDCFDMVNITLKQESYVPFVVDTVKIIAKAISMYIE-----DDCGKIPFHKCTLAQSGFRG 434

  Fly   535 EFLQQMGKLHFLGVSGP--VSFSGPDRVGTTAFYQIQ-RGLLEPVALYYPATDALDFR------- 589
            |.||:..:...|..:.|  :..:| |.:|....:|:. .|:.:.|..:....|.|...
Worm   435 ERLQRYYRNMSLIKNEPALIDANG-DGIGRYDVFQLDINGVYQKVGKWRSTDDFLSVEVEKIRHA 498

  Fly   590 ----------------CPR--------------CRP----VKWHS---------GQVPIAKRVFK 611
                            |||              |.|    ...|:         |.||.....|.
Worm   499 FKTAHGERPMSVCSTDCPRGHYRAYQDQTCCWACIPCDTSTSIHNETSCEECAVGMVPDRTLHFC 563

  Fly   612 LRVATIA----------PLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVG 666
            :.:..::          |.||      |::|||..|..::..|.|.....|..|..:|......|
Worm   564 VPIPPVSMQWDTTWSLIPAAF------STLGIASTIFVVSVFLKFSNTPVIMASGRELCYCMMSG 622

  Fly   667 CIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVF 731
            ....|.....|         ........|:....|:....|..:.::..||.|:.|:| :..|..
Worm   623 IGMCYTLTFFL---------VSQPTVITCSMTRILMGLSMSAIYAAIITKTNRLARVF-KPDSAQ 677

  Fly   732 KDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVE---VCR 793
            :.:.:.....:.:..|::.|..:...:|::.||              ....:|:..:.|   .|:
Worm   678 RPRFITPKAQVGICMGIVSVQLIGTFVWILFDP--------------PGTMIVFPTRTEAVLTCK 728

  Fly   794 SQHTQTWLSVLYAYKGLLLVVG--VYMAWETRHVKIPA-LNDSQYIGVSVYSVVITSAIVVVLAN 855
            :..:...:|:||   .:||:|.  || |::||  |||. .|::::||.::||..|
Worm   729 ATTSHLLISLLY---NILLIVACTVY-AFKTR--KIPENFNETRHIGFTMYSTCI---------- 777

  Fly   856 LISERVTLAF------------ITITALI----LTSTTATLCLLFIPKLH--------DIWARND 896
                 :.|||            |.||:|.    |:.|.|.:| .|.||::        ::..|..
Worm   778 -----LWLAFGPIYFATQSDFRIQITSLCMCISLSGTVALIC-FFAPKVYIVLFQPYKNVRTRQS 836

  Fly   897 IIDPVIHSMGLKME--------CNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLL 953
            .:..:::.....|.        ||:            |:....|:.||..|.|
Worm   837 AVGRLVNQQMRFMSQLTYNPDGCNS------------YQPMSSNQSYKPSISA------------ 877

  Fly   954 ESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAASKN 996
            |....|::......|..:       |...:....:..|.:.||
Worm   878 EESSHTSNAQVQQPTRAI-------PPHVIEQLAASLPISDKN 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	103/529 (19%)
		ANF_receptor	174..568	CDD:279440	94/457 (21%)
		7tm_3	633..889	CDD:278433	62/277 (22%)
mgl-3	NP_001076735.3	Periplasmic_Binding_Protein_type1	41..493	CDD:385651	107/513 (21%)
		NCD3G	507..556	CDD:369426	7/48 (15%)
		7tmC_mGluRs_group2_3	577..825	CDD:320600	67/299 (22%)
		TM helix 1	577..601	CDD:320600	8/29 (28%)
		TM helix 2	613..634	CDD:320600	4/29 (14%)
		TM helix 3	643..665	CDD:320600	3/21 (14%)
		TM helix 4	689..705	CDD:320600	2/15 (13%)
		TM helix 5	730..753	CDD:320600	8/26 (31%)
		TM helix 6	762..787	CDD:320600	9/39 (23%)
		TM helix 7	794..819	CDD:320600	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910