DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and mgl-2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_492720.3	Gene:	mgl-2 / 172914	WormBaseID:	WBGene00003233	Length:	1035	Species:	Caenorhabditis elegans

Alignment Length:	1145	Identity:	245/1145 - (21%)
Similarity:	400/1145 - (34%)	Gaps:	349/1145 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 ESERRMSPAEMQRNHGKIVLLGLFEL------STSRGP--RPDGLSELGAATMAVEHINRKRLLP 192
            :...||..||:   ||:|.:..||.:      |.|.|.  ...|:.....|.:.|:.:|.:  ||
Worm    23 QQSARMLVAEI---HGEIQIGALFPIHRQIAGSESCGEIWEQYGIQRSEIAMLTVKQLNEE--LP 82

  Fly   193 GYTLELVTNDT--------------------QCD----PGVGVDRFFHAIYTQPSTRMVMLLGSA 233
             :.|.|...|:                    ||.    ||.          .:.|..:|.::|..
Worm    83 -FKLGLSIRDSCWTERIAMEQTIAFLREGVAQCSCCQTPGC----------NKKSVPVVAVIGPG 136

  Fly   234 CSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVT 298
            .|..|.::..::..:.|.||.:.:|:|.|||:.:|.||.|.|..|.....|....:..:.|..|.
Worm   137 KSSSTIAVQNLLQVFRIPQVGYSATTPDLSDKEQFGYFLRVVPSDVFQAQAINRLLHHYNWTYVA 201

  Fly   299 TFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRETDTRIIIGSFSQELAPQI 363
            ..............:|  |...|:.|.:..|.::.   |.:.|...:...:::....||...||:
Worm   202 VLYSAGNYGEKGFESL--EKLIAHRSSSVCIAYSE---KIKTLASEQEYRQVLTRLDSQNSRPQV 261

  Fly   364 L---CEAYRLRMFG------AD-------YAWILHESMGAPWWPDQRTACSNHELQLAVENLIVV 412
            :   ||...:|||.      ||       :.||     |:..|.|:....  .:|:...|....:
Worm   262 VVCFCEGASMRMFFKAQKHLADGKMQMKRFQWI-----GSDGWADRNDVV--EDLEEEAEGSFSI 319

  Fly   413 STH-NSIVGNNVSYSGLN--NHMFNSQLR-----KQSAQFHGQDGFGSGYGSRISIAATQSDSRR 469
            ..| ..|.|....|:.|:  |:..|...|     |.:.||                |.::.|
Worm   320 RIHAPKIPGFRQYYTALHPENNTMNPWFREFWQQKFNCQF----------------AVSKED--- 365

  Fly   470 RRRRGVGGTSGGHLFPEAISQY-----APQTYDAVWAIALALRAA-EEHWRRNEEQSKLDGFDYT 528
            :....:...||.....|   ||     ..|..:::..:||.|:|. ::..|.|
Worm   366 KNNENIRICSGDENLDE---QYKEDPKLSQVINSIRVVALGLKAMYQDRCRDN------------ 415

  Fly   529 RSDMAWEFLQQMGKL---HFLGVSGPVSFSGP---DRVG-TTAFYQI--------------QRGL 572
             |.:..|.|.:.|.|   :.|.|:....|..|   ||.| ..|:|.|              :.|.
Worm   416 -STLCTEMLSRNGTLLYEYLLNVTYSDQFKQPVYFDRNGDPPAWYDILNYIGTKDLDNPYNEVGS 479

  Fly   573 LEPV-------------ALYYPATDALD---------------------FRCPRCRPVKWHS--- 600
            .:.:             ::::..|:.|.                     :.|..|..:::.:
Worm   480 FKSINDYGVEELDMTAKSMFFDKTELLPESVCSRPCGIGQRQRETMACCWICESCLDIQYVNKTT 544

  Fly   601 --------GQVPIAKRV----FKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIK 653
                    |..|.|.|.    ....|.:...........|:..||..::|.||..|.......:|
Worm   545 NQCMNCTLGSWPNANRTGCEYIIPEVVSWTSFGHILALVLAVTGIITSMATLAVFLRHNSTPVVK 609

  Fly   654 LSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTY 718
            .::.:||.|...|.:..||....|    ...||....|.|    || :....|::.:.::..||.
Worm   610 STTRELSYIILSGLVACYAVSFAL----LATPSTTSCFIT----RV-IPPIAFAVVYSALLTKTN 665

  Fly   719 RVHRIFTRTGS-----VFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTD-PMERHLHNLTLEIS 777
            |:.||.  .||     ..|.:.|.....:::...|:.|..::|.:.::.| |      :.|....
Worm   666 RIARIL--AGSKKRILTKKPRFLTTFSQVVITWILVAVQCVIVGVGLMRDWP------DATYAKY 722

  Fly   778 ATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVY 841
            |..|.::.:...|      |:::| :.:.:...|:.:....|::||:  :|. .|::::||.::|
Worm   723 ALPRKLILECDTE------TKSFL-IPFFWDFFLITLCTLYAFKTRN--LPENFNEAKFIGFTMY 778

  Fly   842 SVVITSAIVVVLANLISERVTLAFITITALILT-----STTATLCLLFIPKLHDIWARNDIIDPV 901
            ..|     ||.:|.|:....|    |..||:::     |.:..|.|||.|||:.|         :
Worm   779 CTV-----VVWIAFLVLHMGT----THKALVMSFSYSLSASVALALLFFPKLYII---------L 825

  Fly   902 IHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTT-- 964
            :|.     |.|.|         ..|......|.:....||......|.:.|   |..||:.|:
Worm   826 MHP-----EKNIR---------ASYTTTKLIRCHFGNSQAAYDSTSKQQHL---GSKTTARTSVQ 873

  Fly   965 --SSSTSLLTGGGHLKPELTVTSGI---------------SQTPAASK-NRTPSISG-------- 1003
              |:|.|...|||     :|.|:.:               :||.|||| :|:.||.|
Worm   874 SGSASKSSSMGGG-----VTRTASVHVPVSRGSTHSTDVSTQTEAASKFSRSFSIVGRKKQGLDD 933

  Fly  1004 -------------------ILPNLLL--------------------SVLPPVIPRASWPSAEYMQ 1029
                               ...||||                    :||..|..:|..|...  .
Worm   934 DVQQLVDACRRYQDEKINSSAANLLLEESEDEVGALLADSIENSMRTVLSTVAGKAVVPLVP--M 996

  Fly  1030 IPMRRSVTFASQPQLEEACLPAQDLINLR----LAHQQAT 1065
            :||...||..:.|..|:   ..:.|:..|    ||..|||
Worm   997 VPMIPVVTLPTAPSQED---NFEQLLRSRGVQPLALSQAT 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	108/549 (20%)
		ANF_receptor	174..568	CDD:279440	98/454 (22%)
		7tm_3	633..889	CDD:278433	65/267 (24%)
mgl-2	NP_492720.3	Periplasmic_Binding_Protein_type1	28..482	CDD:385651	112/516 (22%)
		NCD3G	507..556	CDD:369426	3/48 (6%)
		7tmC_mGluR_group1	576..826	CDD:320412	69/293 (24%)
		TM helix 1	577..601	CDD:320412	6/23 (26%)
		TM helix 2	613..634	CDD:320412	7/24 (29%)
		TM helix 3	643..665	CDD:320412	6/26 (23%)
		TM helix 4	693..709	CDD:320412	3/15 (20%)
		TM helix 5	735..758	CDD:320412	4/29 (14%)
		TM helix 6	767..792	CDD:320412	9/29 (31%)
		TM helix 7	795..820	CDD:320412	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910