Protein Alignment GABA-B-R3 and GPR156

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_694547.2
• Gene: GPR156 / 165829
• HGNCID: 20844
• Length: 814
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 166/736 - (22%)
• Similarity: 297/736 - (40%)
• Gaps: 184/736 - (25%)

  Fly   614 VATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLG 678
            :::::|:....:.|..|.|:.|.:.||||.:|.||.:.:|:|||.|:.:|.:|....|::..|.|
Human    42 ISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFG 106

  Fly   679 LDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDK--MLQDIQL 741
            :....:.|   |..|:...|:.:|..|.||.||.:..|::|::::||:.   ..||  :::|:||
Human   107 IQDVLVGS---SMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQR---VPDKRVIIKDLQL 165

  Fly   742 ILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSV-VYQPQVEVCRSQHTQTWLSVLY 805
            :.||..||:.|.:|:..||:|||:: .|..|::.::.|.:.| ........|.|:::..|:::::
Human   166 LGLVAALLMADVILLMTWVLTDPIQ-CLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIW 229

  Fly   806 AYKGLLLVVGVYMAWETRHVKIPALNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITA 870
            ..|||||:.|.|:|..|.||..|.:|.|..|.|.|..:|:.:.::.|:...:.....|.|...:.
Human   230 GCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSG 294

  Fly   871 LILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSM---------------GLKMECNTRRFVVDD 920
            .|...||...|.:|||:|.. |...:..:..|..|               |.:..|:.|    .:
Human   295 GIFVCTTTINCFIFIPQLKQ-WKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPR----GE 354

  Fly   921 RRELQYRVEVQNRVYKKEIQALDAEI----RKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPEL 981
            :..::..:..:|.|    |::|..::    .|:.||:.:..|                 :..||
Human   355 KSSMERLLTEKNAV----IESLQEQVNNAKEKIVRLMSAECT-----------------YDLPE- 397

  Fly   982 TVTSGISQTPAASKNR-TPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLE 1045
                | :..||:|.|: ..:::.:          ..:..|..||.....        |.:.|.
Human   398 ----G-AAPPASSPNKDVQAVASV----------HTLAAAQGPSGHLSD--------FQNDPG-- 437

  Fly  1046 EACLPAQDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQKGLKAAFKSHMGLF 1110
               :.|:|        .|.|...:.....|.|. .:.:|.:.|....::|.|.    |..|:...
Human   438 ---MAARD--------SQCTSGPSSYAQSLEGP-GKDSSFSPGKEEKISDSKD----FSDHLDSG 486

  Fly  1111 TRLIPSSQTA----SCNAIYNNPNQDSIPSEASSHP-NGNHL----KPIHRGSLTKS--GTHLDH 1164
            ....|.::.:    ..:.:..||:|..:|....|.| ...||    :|..|.|...|  ...|..
Human   487 CSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQE 551

  Fly  1165 LTKD---------------------------PNFLPIPTISG----------------------- 1179
            :.:|                           |..:|:....|
Human   552 VLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSA 616

  Fly  1180 ----GEQGDQTLGGKYVKLLETKVNFQLPSNRRPSVVQQPPSLRERVRGSPRFPHRILPPTCSLS 1240
                |.:.::|:.|.:.:|       .:.:...||:..|....|.| |.|.|.|.  ||
Human   617 PSSVGHRANRTVPGAHSRL-------HVQNGDSPSLAPQTTDSRVR-RPSSRKPS--LP------ 665

  Fly  1241 ALAESEDRPGDSTSILGSCKS 1261
              ::.:||||   ::.||.:|
Human   666 --SDPQDRPG---TLEGSKQS 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361
		ANF_receptor	174..568	CDD:279440
		7tm_3	633..889	CDD:278433	83/258 (32%)
GPR156	NP_694547.2	7tm_3	71..312	CDD:278433	78/247 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..545		30/148 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..724		25/146 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	769..792

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810