DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and GPRMGL5

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_313901.4	Gene:	GPRMGL5 / 1274862	VectorBaseID:	AGAP005034	Length:	1051	Species:	Anopheles gambiae

Alignment Length:	955	Identity:	209/955 - (21%)
Similarity:	350/955 - (36%)	Gaps:	222/955 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KYKRTKVKRRQQRLNSHSNL----PGST---NASHAHHLLNLPPRQRYLKVNQVFESERRM---- 141
            |:||....:.|:...|...|    |||:   :.:...|      .|.:|.:....:.:::.
Mosquito   113 KHKRHYASQHQRTNASIGGLQHYTPGSSSWPDGTPEEH------EQTFLMLQDDQDGDQQQHDGS 171

  Fly   142 -SPAEMQRNH----------------GKIVLLGLF-----ELSTSRGP-RPD-GLSELGAATMAV 182
             :|...|..|                |.::|.||.     |.|.:.|| .|. |:..|......:
Mosquito   172 AAPGLKQLKHHGPVPVWPVKREAVVEGDLILGGLMMVHSREDSVTCGPIMPQGGIQALETMLYTL 236

  Fly   183 EHINRKRLLPGYTLELVTNDTQCDPG-----VGVDRFFHAI--------YTQPS----TRMVM-L 229
            :.||.:.|:|..|:.....| .||..     :.||....:|        |...|    .:::. :
Mosquito   237 DKINEQGLVPNVTIGAHILD-DCDKDTYGLEMAVDFIKGSISNIDDINDYDNCSKGHKKKIISGV 300

  Fly   230 LGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGW 294
            :|:|.|..:..:|.::..:.|.||||.||||.||:::.|.||.||:..|.....|.:..::|.||
Mosquito   301 VGAASSVTSIQVANLLRLFKIPQVSFFSTSPELSNKQRFEYFSRTIPSDHYQVKAIVDIVQKLGW 365

  Fly   295 GTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQL------------------L 341
            ..::...:.......|...|...|...|| |.|.        ||:|                  |
Mosquito   366 SYISIIYEESNYGIKAFEELDDLLSKHNI-CIAV--------KEKLVKDSGVADTIAYDNIVLKL 421

  Fly   342 LLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAV 406
            |.:.....:||....||:| :::....|..:.|. ::||     |:..|..:......:|.:  |
Mosquito   422 LTKPRAKGVIIFGSDQEVA-EVMKAVRRQNVTGV-FSWI-----GSDGWSARNLVSDGNEAE--V 477

  Fly   407 ENLIVVSTH-NSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGS------RISIAATQ 464
            |..:.|... |.::|....:  ||..:.|::......:| .::.|...|.:      ........
Mosquito   478 EGTLSVQPQANPVIGFEDYF--LNLTVINNKRNPWFVEF-WENNFQCKYPNSPYTPYNKDYKKVC 539

  Fly   465 SDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDG----F 525
            |.:.:..:|.:.       |.:.: |:..   |||.|...|.        :|..|...||    .
Mosquito   540 STTEKLLKRDLD-------FEDQL-QFVS---DAVMAFGYAF--------KNMHQELCDGKPGLC 585

  Fly   526 DYTRSDMAWEFLQQMGKLHFLGVSG-----PVSFSGPDRVGTTAFYQI--QRGLLEPVALYYPA- 582
            |........|.|:.:.|..|:|:||     .|:..||.|.....|.|:  :|.....|..||..
Mosquito   586 DAMNPTKGSELLKYLRKADFIGLSGDRFNFDVNGDGPARYNIIHFKQVAPERYTWIKVGEYYQGE 650

  Fly   583 ----TDALDFR--------------CPRCRPVK--------WH---------------------- 599
                ...:.||              |.|.:..|        ||
Mosquito   651 LRLNMQDIQFRTKDSMPPESVCSRPCERGQAKKYVEGEGCCWHCFNCTQYQIRSPNDETHCVNCP 715

  Fly   600 SGQVP--IAKRVFKLRVATIAPLAFYTIA--TLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLS 660
            .|.:|  ..:...::..:.:.|.:|..|.  |.||.||.:....:...|.......::.|..:||
Mosquito   716 RGTLPDVYHEECQQIPESYLRPESFLAIGAMTFSSFGILITFFVIGVFLKHNDTPIVRASGRELS 780

  Fly   661 NITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF- 724
            .:...|.:..:      |:.::.:....|   .||..:.:.....|::.:.::..||.|:.|||
Mosquito   781 YVLLSGILLCF------GVTYTLVIKPND---IVCGVQRFWSGFSFTVVYAALLTKTNRIARIFN 836

  Fly   725 TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQV 789
            ..|.|..:...:.....:::.|.|:....|:..:|::..|... :|              |.|..
Mosquito   837 ASTKSAKRPSFISPHSQLVICGILVSFQILINAVWMIVSPAHA-MH--------------YYPTR 886

  Fly   790 E----VCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITSAI 849
            |    ||.| :|.....:.:.|...|:|:....|..||  |.| |.|:|:|||.::|:..:....
Mosquito   887 EDNLLVCNS-YTDASYMIAFFYPIFLIVICTVYAVLTR--KTPEAFNESKYIGFTMYTTCVIWLA 948

  Fly   850 VVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWAR 894
            .:.|....:..|.|...|::..|..|.|.||..||.|||:.|..|
Mosquito   949 FIPLYFGTANNVQLRIFTMSMTISLSATVTLVCLFSPKLYIILIR 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	115/512 (22%)
		ANF_receptor	174..568	CDD:279440	100/445 (22%)
		7tm_3	633..889	CDD:278433	60/261 (23%)
GPRMGL5	XP_313901.4	PBP1_mGluR	198..655	CDD:107357	115/497 (23%)
		ANF_receptor	227..628	CDD:279440	99/441 (22%)
		NCD3G	669..718	CDD:284890	5/48 (10%)
		RhaT	735..993	CDD:223769	69/284 (24%)
		7tm_3	753..989	CDD:278433	61/262 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910