Protein Alignment GABA-B-R3 and GABA-B-R3

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_061516429.1
• Gene: GABA-B-R3 / 1271397
• VectorBaseID: AGAMI1_005902
• Length: 1106
• Species: Anopheles gambiae
• Alignment Length: 1185
• Identity: 618/1185 - (52%)
• Similarity: 773/1185 - (65%)
• Gaps: 163/1185 - (13%)

  Fly   131 VNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRG-PRPDGLSELGAATMAVEHINRKRLLPGY 194
            :|.|||   |..||..:|...::.:|||||||:..| .|.:|||||.||.:||:||||:.||.||
Mosquito    51 INTVFE---RTRPAGSERRAREVTILGLFELSSREGATRREGLSELAAAQLAVQHINRRGLLLGY 112

  Fly   195 TLELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTS 259
            .|:|:||||:|||||||||||||:||..|.|::|:||||||||||||||:||||||:||||||||
Mosquito   113 KLKLITNDTKCDPGVGVDRFFHALYTHQSKRIIMVLGSACSEVTESLAKIVPYWNILQVSFGSTS 177

  Fly   260 PALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANIS 324
            ||||||||||.|||||||||||:||||||:..|||.||.|||||||.:|||||:||||||.|||:
Mosquito   178 PALSDRREFPLFYRTVAPDSSHHPARIAFLMHFGWDTVATFSQNEEGYSLAVNDLVTELERANIT 242

  Fly   325 CAATITFAATDFKEQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPW 389
            |||||:||.|||||||.|||:.|.|:||||||.|:|||:.||.|.|.|:||:|||||.::..:.|
Mosquito   243 CAATISFAETDFKEQLKLLRDRDVRVIIGSFSHEIAPQVFCEVYNLGMYGAEYAWILQDTYISSW 307

  Fly   390 W-----PDQRTA-CSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQD 448
            |     |:..:| |::..|..||||||:||::|||||...:.|||.|.:|..:||:.:
Mosquito   308 WLAGDLPETGSAPCTSRALLTAVENLIIVSSYNSIVGMGTALSGLTNDIFLQKLREMN------- 365

  Fly   449 GFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHW 513
                                      |.|         |:||:||||||||||:|||||.||..|
Mosquito   366 --------------------------VTG---------AVSQFAPQTYDAVWAMALALRGAERSW 395

  Fly   514 RRN-EEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVA 577
            .:: ..:.:|..:||||.|:|.|.|:|...|.|.|:||||||.|.||:|||:|:||:.|.||.:|
Mosquito   396 SQSVPHRVRLADYDYTRYDIAQELLRQFDLLKFNGISGPVSFEGADRIGTTSFHQIRAGQLEMIA 460

  Fly   578 LYYPATDALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAF 642
            .|||....|||.|..|.|:.|..||||||||:.:|||.||.|.||||:..||.:||.:::.||..
Mosquito   461 FYYPKNATLDFGCRYCVPIVWPGGQVPIAKRILRLRVDTIDPFAFYTVVILSLIGIGISVLFLGL 525

  Fly   643 NLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFS 707
            ||.|||||||||||||||.||..||:.||...|||||||||||.:..:|:|:|.||:|.||||||
Mosquito   526 NLRFRKLKAIKLSSPKLSTITVCGCMLVYTATILLGLDHSTLPWSSVTFSTICMARIYFLSAGFS 590

  Fly   708 LAFGSMFAKTYRVHRIFTRT-GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHN 771
            ||||||||||:||:||||.: |.:.:||:|:|.|||.::|.||||||.:|:.|:..|||||||||
Mosquito   591 LAFGSMFAKTFRVYRIFTHSAGGLCRDKILRDTQLISVIGALLLVDAFVVSFWMAADPMERHLHN 655

  Fly   772 LTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPALNDSQYI 836
            |:||||.||||||:.||||:|||:|.::||.:|||||||||:|||||||:||:|||.||||||||
Mosquito   656 LSLEISTTDRSVVFLPQVELCRSRHYESWLGMLYAYKGLLLLVGVYMAWQTRNVKISALNDSQYI 720

  Fly   837 GVSVYSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPV 901
            |:||||||||||.|||||||:.||||||||.....:|.||||||||||:||:.||:.:.::.||:
Mosquito   721 GISVYSVVITSASVVVLANLLYERVTLAFIITAGFVLISTTATLCLLFLPKIKDIFEKGEVYDPI 785

  Fly   902 IHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSS 966
            |||||||||.||||||:|||||||:|||||||||:||::.|||||.:|||.|:.....:|..:|
Mosquito   786 IHSMGLKMEFNTRRFVLDDRRELQFRVEVQNRVYRKELELLDAEICRLERALQERSPQSSPLSS- 849

  Fly   967 STSLLTGGGHLKPELTVTSGISQTPAASKNRTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIP 1031
                       :|.|.     ...|.|...  |..|..||.||||||||:||||||||.:.|..|
Mosquito   850 -----------EPNLP-----DSRPCAIAR--PHGSSGLPMLLLSVLPPIIPRASWPSVDPMLSP 896

  Fly  1032 MRRSVTFASQPQLE-----------EACLPAQDLINLRLAHQQATEAKTGLINRLRGIF------ 1079
            |:|::.|:|||:::           |..|.:...:.....|.....:.:|::.::|.:|
Mosquito   897 MKRNIAFSSQPKIDPAVTLAPTGSRERILTSSSRVGSDEPHTLPNGSSSGVMGKIRHMFAPRLHK 961

  Fly  1080 --SRTTSSNKGSTASLADQKGLKAAFKSHMGLFTRLIPSSQTASCNAIYNNPNQDSIPSEASSHP 1142
              |.|.....||:.|        |..||.:.:|..:               ..:|.:|..
Mosquito   962 TPSATMLGGTGSSTS--------AIRKSALAIFNEI---------------DTEDDLPQS----- 998

  Fly  1143 NGNHLKPIHRGSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVKLLETKVNFQLPSN- 1206
                                           |.||....:.:.||.|.     |.:|||.||.|
Mosquito   999 -------------------------------IYTIDKPTREELTLTGS-----EPRVNFVLPPNG 1027

  Fly  1207 -RRPSVVQQPPSLRERVRGSPRFPHRILPPTCSLSALAESEDRPGDSTSILGSCKSIPRISLQQA 1270
             ||.|.|||...:|:|:||||||||||.|.|.||:.|  ..:||..|...:.||:.|.....:..
Mosquito  1028 WRRSSTVQQQGPVRDRIRGSPRFPHRICPQTTSLTEL--GIERPRISFLTVKSCEQIHGKPCESR 1090

  Fly  1271 TSGGTWKSMETAGKS 1285
            |.   ||||::..||
Mosquito  1091 TK---WKSMDSFSKS 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	263/451 (58%)
		7tmC_GABA-B-like	621..892	CDD:320175	188/271 (69%)
		TM helix 1	621..645	CDD:320175	11/23 (48%)
		TM helix 2	657..678	CDD:320175	12/20 (60%)
		TM helix 3	696..720	CDD:320175	19/23 (83%)
		TM helix 4	741..761	CDD:320175	11/19 (58%)
		TM helix 5	797..823	CDD:320175	18/25 (72%)
		TM helix 6	832..855	CDD:320175	20/22 (91%)
		TM helix 7	862..887	CDD:320175	16/24 (67%)
GABA-B-R3	XP_061516429.1	None