Protein Alignment GABA-B-R3 and LOC108646252

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_017948194.2
• Gene: LOC108646252 / 108646252
• XenbaseID: XB-GENE-29090707
• Length: 834
• Species: Xenopus tropicalis
• Alignment Length: 902
• Identity: 174/902 - (19%)
• Similarity: 317/902 - (35%)
• Gaps: 248/902 - (27%)

  Fly   149 NHGKI----VLLG---------LFELST-SRGPRP--------DGLSELGAATMAVEHINRK-RL 190
            :||.:    :|:|         :|.|:| .:.|.|        |...:......|||.|||. .|
 Frog    10 SHGILEPGDLLIGAVIPIHTDSIFPLATYKQKPTPDICKSFRLDFYQQFQTFRFAVEEINRNPEL 74

  Fly   191 LPGYTLELVTNDT----QCDPG------VGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAKVV 245
            ||..||.....|:    |.:.|      .|:::.......|....:..::|.:.|..:..:|.::
 Frog    75 LPNSTLGFYVYDSCAVLQRELGGTIWMITGLNQVIPNYCCQVHPPLTAVIGHSTSTFSILVAHIM 139

  Fly   246 PYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLA 310
            ..:...|||:.|||..|||:|:||.|:|||..|..........:..|.|..|...:.|:: :...
 Frog   140 GLYRFPQVSYFSTSSLLSDKRQFPSFFRTVPSDDFQARGLAQMVLHFKWKWVGLIASNDD-YGTE 203

  Fly   311 VNNLVTELEAANISCAATITFAATDFKEQLL-----LLRETDTRIIIGSFSQE-----LAPQILC 365
            |..::.:......:|.|...:.:.:...|.|     .::::...::| .||.:     |..::|.
 Frog   204 VIEVIRQEVVKEGACVAYTVYMSDNLLNQNLPNIVKTIKDSSANVLI-VFSVDFYLFPLLDEMLK 267

  Fly   366 EAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLNN 430
            :....:.|.|..||                         ::.|.:.|:.:.|::...:.::..::
 Frog   268 QNVTGKTFVASEAW-------------------------SISNRLAVNKYVSLLSGTIGFAFFSS 307

  Fly   431 HMFNSQLRKQSAQFHGQDG-----------FGSGYGSRISIAATQSDSRR--------------- 469
            .:...|....|...:...|           ||..:..:.::..|.:..::
 Frog   308 EIKGLQKFLNSMTIYNTPGIYWAKELWEEVFGCTFVDQKNLTVTLNIKKQCTGEEHLSSVQNIYN 372

  Fly   470 -------------------------RRRRGVGGT-------SGGHLFPEAISQY----------- 491
                                     |:.|.:||.       ..||..|..:..|
 Frog   373 DVSILRASYNIYTAVYVIATALHDLRQCRSLGGALVGNNCLDIGHFKPWQLMSYFRKVRVTLNNA 437

  Fly   492 ----------APQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGK-LHF 545
                      .|..||.|            :|:.        |.|.|...|...|....|. :.|
 Frog   438 RDVFFDKDGNPPAVYDIV------------NWQL--------GSDGTIKQMKSTFCPDFGLIIDF 482

  Fly   546 LGVSGP---VSFSGPDRVGTTAFYQ-IQRGLLEPVALYYPA----------TDALD-FRCP---- 591
            :....|   .|.|.|:     .|.| ::.|  |||..:..:          |||:: ::||
 Frog   483 ISSKVPNSVCSQSCPE-----GFKQSLKEG--EPVCCFQCSPCAQGEISNQTDAIECWKCPWDMW 540

  Fly   592 ------RC--RPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRK 648
                  ||  :|:::.|.:..:.                .|:||:|:....:.|......:|::.
 Frog   541 PNSARDRCLTKPIEFLSYEDYLG----------------ITLATISTFSSMVPIFIFRLFVHYKS 589

  Fly   649 LKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSM 713
            ...::.::..:|.|..|...|.:    |..|.....|..|.     |..|.......|:|....:
 Frog   590 TPIVRANNYSVSCILLVSLSFCF----LCALAFIGYPQPEK-----CLLRQAAFGLVFTLCVSCI 645

  Fly   714 FAKTYRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEI 776
            .|||..|...|  |:.||..| |........:::.....:...|...|:...|     ..|...|
 Frog   646 LAKTVIVVFAFMATKPGSSLK-KWTTPRVPYMIITICTFIQLTLCVFWLTISP-----PFLQFNI 704

  Fly   777 SATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSV 840
            .|....:|.:     | ::::|.....:..|.|:|..|...:|:..|  ::| ..|:::.|..|:
 Frog   705 EAKPGIIVVE-----C-NENSQFAFWCMLGYLGMLATVSFTVAFLAR--RLPDNFNEAKLITFSM 761

  Fly   841 YSVVITSAIVVVLANLISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDI 897
            .: .::..:..:.|:|.::......:.|.| ||||:.|.:..:|:||...|..|.|:
 Frog   762 LA-FLSVWVYFIPASLSAQGKYTVAMEIFA-ILTSSWALVFCMFLPKCFIILFRPDM 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	108/589 (18%)
		7tmC_GABA-B-like	621..892	CDD:320175	59/273 (22%)
		TM helix 1	621..645	CDD:320175	5/23 (22%)
		TM helix 2	657..678	CDD:320175	5/20 (25%)
		TM helix 3	696..720	CDD:320175	6/23 (26%)
		TM helix 4	741..761	CDD:320175	2/19 (11%)
		TM helix 5	797..823	CDD:320175	6/25 (24%)
		TM helix 6	832..855	CDD:320175	2/22 (9%)
		TM helix 7	862..887	CDD:320175	8/24 (33%)
LOC108646252	XP_017948194.2	Periplasmic_Binding_Protein_type1	20..481	CDD:471960	90/507 (18%)
		NCD3G	488..541	CDD:462210	15/59 (25%)
		7tmC_V2R_pheromone	562..812	CDD:320410	60/290 (21%)
		TM helix 1	562..586	CDD:320410	5/39 (13%)
		TM helix 2	598..619	CDD:320410	6/24 (25%)
		TM helix 3	628..652	CDD:320410	6/23 (26%)
		TM helix 4	676..692	CDD:320410	1/15 (7%)
		TM helix 5	719..745	CDD:320410	6/25 (24%)
		TM helix 6	753..776	CDD:320410	3/23 (13%)
		TM helix 7	781..806	CDD:320410	8/25 (32%)