Protein Alignment GABA-B-R3 and Grm3

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_862898.1
• Gene: Grm3 / 108069
• MGIID: 1351340
• Length: 879
• Species: Mus musculus
• Alignment Length: 993
• Identity: 197/993 - (19%)
• Similarity: 332/993 - (33%)
• Gaps: 336/993 - (33%)

  Fly   151 GKIVLLGLFELSTSRGPRPD---------GLSELGAATMAVEHINRKR-LLPG-----YTLELVT 200
            |.:||.|||.:: .:|...:         |:..|.|...|::.||:.. ||||     :.|:..:
Mouse    37 GDLVLGGLFPIN-EKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCS 100

  Fly   201 NDT----------------------QCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTESLAK 243
            .||                      .|..|      .:||.......:..::|.:.|.|:..:|.
Mouse   101 RDTYALEQSLEFVRASLTKVDEAEYMCPDG------SYAIQENIPLLIAGVIGGSYSSVSIQVAN 159

  Fly   244 VVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHS 308
            ::..:.|.|:|:.|||..|||:..:.||.|||.||.....|....:|.|.|..|:|.:...:...
Mouse   160 LLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGE 224

  Fly   309 LAVNNLVTELEAANISCAATITFAATDFKEQL-----LLLRETDTRIIIGSFSQELAPQILCEAY 368
            ..:.....|....||..|.......::.::..     .||::.:.|:::.....:.:.:::..|.
Mouse   225 TGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAS 289

  Fly   369 RLRMFGADYAWILHESMGA-------------------------------------------PWW 390
            |:   .|.:.|:..:..||                                           ||:
Mouse   290 RV---NASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWF 351

  Fly   391 PD---QRTACS-----NH----ELQLAVE--------------NLIVVSTH------NSIVGNNV 423
            .|   |:..||     ||    :..||::              |.:....|      .::..|..
Mouse   352 RDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTT 416

  Fly   424 SYSGLNNHMFNSQLRKQ-------SAQFHGQDG---------FGSGYGSRISIAATQSDSRRRRR 472
            ........:...:|.|.       :|.|:...|         :|.|.| |.::...|.
Mouse   417 KLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMG-RYNVFNFQH------- 473

  Fly   473 RGVGGTSG----GHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMA 533
              :||...    ||                 ||..|.|.....||.||
Mouse   474 --IGGKYSYLKVGH-----------------WAETLYLDVDSIHWSRN----------------- 502

  Fly   534 WEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRG-----LLEPVALYYPATDALDFRCPRC 593
                           |.|.| ...|.........:|.|     :..|...|....|  :|.|..|
Mouse   503 ---------------SVPTS-QCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVD--EFTCMDC 549

  Fly   594 RPVKWH----SGQVPIAKRVFKLRVA-TIAPLAFYTIATLSSVGIALAI-AFLAFNLHFRKLKAI 652
            .|.:|.    ||...:.:...:...| .|.|:   |||.|..:...:.| .|:..|    ....:
Mouse   550 GPGQWPTADLSGCYNLPEDYIRWEDAWAIGPV---TIACLGFMCTCIVITVFIKHN----NTPLV 607

  Fly   653 KLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKT 717
            |.|..:|..|...|....|......    ...||     ..:|..|...|...|::.:.::..||
Mouse   608 KASGRELCYILLFGVSLSYCMTFFF----IAKPS-----PVICALRRLGLGTSFAICYSALLTKT 663

  Fly   718 YRVHRIF--TRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATD 780
            ..:.|||  .:.|:. :.|.:.....:.:..||:||..::|::|::            ||...|.
Mouse   664 NCIARIFDGVKNGAQ-RPKFISPSSQVFICLGLILVQIVMVSVWLI------------LETPGTR 715

  Fly   781 RSVVYQPQVEV---CRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVY 841
            |..:.:.:..|   |..:.:...:|:  .|..:|:::....|::||  |.|. .|::::||.::|
Mouse   716 RYTLPEKRETVILKCNVKDSSMLISL--TYDVVLVILCTVYAFKTR--KCPENFNEAKFIGFTMY 776

  Fly   842 SVVITSAIVVVLANLISERVTLAFITITALILTST-----TATLCL------------LFIPKLH 889
            :..|               :.|||:.|  ..:||:     |.|:|:            ||.||:|
Mouse   777 TTCI---------------IWLAFLPI--FYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVH 824

  Fly   890 DIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQALDAEIRKLERLLE 954
            .:     :..|                        |..| |.:|::             |.|...
Mouse   825 IV-----LFQP------------------------QKNV-VTHRLH-------------LNRFSV 846

  Fly   955 SGLTTTSTTTSSSTSLLT 972
            ||..||.:.:|:||.:.|
Mouse   847 SGTATTYSQSSASTYVPT 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	109/589 (19%)
		7tmC_GABA-B-like	621..892	CDD:320175	65/294 (22%)
		TM helix 1	621..645	CDD:320175	7/24 (29%)
		TM helix 2	657..678	CDD:320175	4/20 (20%)
		TM helix 3	696..720	CDD:320175	5/23 (22%)
		TM helix 4	741..761	CDD:320175	6/19 (32%)
		TM helix 5	797..823	CDD:320175	4/25 (16%)
		TM helix 6	832..855	CDD:320175	4/22 (18%)
		TM helix 7	862..887	CDD:320175	11/41 (27%)
Grm3	NP_862898.1	PBP1_mGluR_groupII	33..494	CDD:380598	94/493 (19%)
		NCD3G	505..555	CDD:462210	12/52 (23%)
		7tmC_mGluR3	575..828	CDD:320564	68/307 (22%)
		TM helix 1	575..600	CDD:320564	9/27 (33%)
		TM helix 2	612..633	CDD:320564	4/24 (17%)
		TM helix 3	642..666	CDD:320564	5/23 (22%)
		TM helix 4	688..708	CDD:320564	6/19 (32%)
		TM helix 5	733..759	CDD:320564	4/27 (15%)
		TM helix 6	767..790	CDD:320564	8/39 (21%)
		TM helix 7	797..822	CDD:320564	5/24 (21%)