Protein Alignment GABA-B-R3 and LOC105946413

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_031751042.1
• Gene: LOC105946413 / 105946413
• -ID: -
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 952
• Identity: 191/952 - (20%)
• Similarity: 327/952 - (34%)
• Gaps: 312/952 - (32%)

  Fly   128 YLKVNQVFESERRMSPAEMQRNHGKIVLLGLFELSTSRGPRP------DGLSELGAAT------- 179
            :|::.:.:|....|       ..|.|::.|:|.::|...|..      :.:..:||..
 Frog    65 HLEIIKTYEEYEYM-------KEGDIMIAGVFTVNTLIVPISYPMDFYNSMLCVGALAKNYRQFV 122

  Fly   180 ---MAVEHINRKR-LLPGYTLELVTNDTQCDPGVGVDRFFHAI---------YTQPSTRMVM-LL 230
               .|:|:||:.. |||..||.....|:..||...|...|..:         |:....|.:. .:
 Frog   123 DFLFAIENINKDPVLLPNLTLGYHIYDSCGDPRKAVRSVFQILSGTREPVPNYSCVGKRNIAGFI 187

  Fly   231 GSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWG 295
            |...||.|..:|:::..:...|:|:|:|.|:||||..||||:|.|..|.||..|....::.|.|.
 Frog   188 GDLTSETTVPIAQILNVYGYAQISYGATDPSLSDRHAFPYFFRMVQSDHSHYLALSKLLKYFKWT 252

  Fly   296 TVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFA-----ATDFKEQLLLLRETDTRIIIGSF 355
            .:.....|:......:..|.:.|....|....||..:     ...:|....:::::.|.:|
 Frog   253 WIGIIRFNDNSGEKELQLLSSYLSVEGICVEFTIKISNYIENIAVYKMYREIIQKSSTSVI---- 313

  Fly   356 SQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVG 420
                   |||                    |.|         |.:.:...:....|..|...::.
 Frog   314 -------ILC--------------------GTP---------SVNFVGTFINMTDVFRTKTLVIS 342

  Fly   421 NNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFP 485
            :.|:   .|:::.:..|.    .|||..||       :..|....||.:.|.           |.
 Frog   343 STVA---ANHNIIDYHLE----LFHGSLGF-------VQHAIYSLDSPQMRS-----------FI 382

  Fly   486 EAISQY---APQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFD---------YTRSDMAWEFLQ 538
            |::...   ..:..:.:|        .:.|...:|:.:|.|.::         .||.|...:.|.
 Frog   383 ESLHPLRNPEDKLLEDIW--------MQYHLCLSEDPNKNDLYERVYAFKLHNCTRQDNITDILS 439

  Fly   539 QMGKLHFLGVSGPVSF---------------SGPDRVG----------------------TTAF- 565
            ...||||    .||.|               |...:.|                      |..|
 Frog   440 IDSKLHF----PPVHFAVHIMSGALHKMQNTSEKSKTGHYYKYKLHHYLKNIQYKTIKNKTNIFN 500

  Fly   566 --------YQIQRGLLEP---VALYY------------------------------PATDALD-- 587
                    |.|...:::|   |.:.|                              |.....|
 Frog   501 ENGELIGEYLIYNYIMDPGAQVIVNYLGLFNPWASSNQKLEIASSKIRWKTNDSKIPRAQCSDNC 565

  Fly   588 ---FR------------------------------CPRCRPVKW---HSGQVPIAKRVF------ 610
               ||                              |.||..::|   :..|..|....|
 Frog   566 PPGFRKAPNPGAQTCCYDCVPCPTGDISTTTDSEICTRCPDMEWPNENKNQCIIRNEEFLSYNNY 630

  Fly   611 --KLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYAT 673
              .:..::|:.|.|.|  ||..:|:.:.         ||....::.::..||.:..|.....:.:
 Frog   631 MISVFFSSISVLFFLT--TLLILGVFIT---------FRNSPIVRANNRSLSFLLLVSIKLSFLS 684

  Fly   674 VIL-LG--LDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKD 733
            |.| ||  :|            ..|..|:......||:|..|:.|||..|...|  |:.||.::.
 Frog   685 VFLFLGRPVD------------ITCMLRIITFGITFSIAVSSLLAKTIMVCVAFKATKPGSSWRK 737

  Fly   734 ----KMLQDIQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRS 794
                |:...:  :|....:.::  :.:|...::.|.:.      |:|..:..:::.|     |..
 Frog   738 WLGVKLSNSV--VLFCSSIQII--ICMTWLAISPPFQE------LDIHTSPGTIIIQ-----CNE 787

  Fly   795 QHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVY---SVVITSAIVVVLAN 855
            .....:.||: .|.|||..|...:|:..|  .:| :.|:::||..|:.   ||.||    ::.|.
 Frog   788 GSAIGFYSVI-GYMGLLAAVSFVLAFLAR--SLPDSFNEAKYITFSMLLFCSVWIT----MIPAY 845

  Fly   856 LISERVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDI 897
            |.::......:.|.| ||||:...|..:|:||.:.|..|.::
 Frog   846 LSTKGKNTVCVEIFA-ILTSSAGLLASIFLPKCYIILLRPEM 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	108/590 (18%)
		ANF_receptor	174..568	CDD:279440	96/477 (20%)
		7tm_3	633..889	CDD:278433	62/268 (23%)
LOC105946413	XP_031751042.1	Periplasmic_Binding_Protein_type1	84..549	CDD:415822	104/541 (19%)
		NCD3G	557..610	CDD:400103	7/52 (13%)
		7tmC_V2R_pheromone	632..882	CDD:320410	70/295 (24%)
		TM helix 2	668..689	CDD:320410	5/20 (25%)
		TM helix 3	698..720	CDD:320410	7/21 (33%)
		TM helix 4	746..762	CDD:320410	1/19 (5%)
		TM helix 5	789..812	CDD:320410	7/23 (30%)
		TM helix 6	824..846	CDD:320410	8/25 (32%)
		TM helix 7	851..876	CDD:320410	8/25 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910