DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfcv1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_021328990.1	Gene:	olfcv1 / 101884304	ZFINID:	ZDB-GENE-050419-263	Length:	848	Species:	Danio rerio

Alignment Length:	896	Identity:	189/896 - (21%)
Similarity:	331/896 - (36%)	Gaps:	215/896 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLF------ELS-TSRGPRP--------DGLSELGAATM--AVEHI-NRKRLLPGYTLE 197
            |...:.|:|      ||| |....:|        |.::...|.||  |||.| |||.|||.:||.
Zfish    35 GDFTIGGIFPLHYRVELSPTDYMKKPLTAMCRGFDPMAFHWALTMGLAVEEINNRKDLLPEHTLA 99

  Fly   198 LVTNDTQCDPGVGVDRFFHAIYTQPSTRMVM---------LLGSACSEVTESLAKVVPYWNIVQV 253
            ....|:...|.:.......|:..|...:..|         |:|.:.|..:..:::.:..:.|..:
Zfish   100 YRIFDSCATPVMAQKAVLAALNGQDVVQSFMCSGASPLLGLIGESGSSQSIVVSRTLEPFRIPMI 164

  Fly   254 SFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTEL 318
            |:.||...||||::||.|:|.|..|.....|....:::|.|..:...:::.:....|:..|..|:
Zfish   165 SYFSTCSCLSDRKQFPTFFRVVPSDDYQVKAIAQLLKRFDWTWIGVVTEDHDYGRFALQGLKREI 229

  Fly   319 EAANISCAATITFAATDFKEQ-----LLLLRETDTR-IIIGSFSQELAPQILCEAYRLRMFGADY 377
            |..|| |.|.......|:.::     |.:::|:..: :::.|...|..| .|.|.....:.|..
Zfish   230 ENTNI-CLAYHEMIPKDYTQERVLKILKVMKESTAKVVVVFSGEGEFYP-FLTEFVAQNITGIQ- 291

  Fly   378 AWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYS-------GLNNHMFNS 435
             ||..|:     |               |...::..|: |.:...:.::       ||.:::...
Zfish   292 -WIASEA-----W---------------VTASMLAETY-SFLDGTIGFAIRQGHVPGLQDYIRTV 334

  Fly   436 QLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQY----APQ-- 494
            ...|..:....|:.:.:.||...|.:...|.        :...:|.....:..|.|    :|:
Zfish   335 TPEKYPSIPQVQELWEALYGCSPSTSTLSSH--------LPSCTGKETLRKEYSAYMNTSSPRVT 391

  Fly   495 --TYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSD--MAWE---FLQQM------------ 540
              .|.||:|.|.:|....|  .|| .....:.|.....:  ..|:   :||::
Zfish   392 YNVYKAVYAFAHSLHNLIE--CRN-GHGPFENFSCANLNNVFPWQLQHYLQEISFSISGEEVNFD 453

  Fly   541 -------------------GKLHFL--GVSGPVSFSGPDRV---------------------GTT 563
                               |.:.|:  |:......||.:.|                     |.|
Zfish   454 IKGDAIPSYDLINWQRSASGDMQFIKVGLYDGAQNSGKELVIEKQAITWSNQQTKARSVCSNGCT 518

  Fly   564 AFYQ--IQRGLLEPVALY--YPA--------TDALDFRCPRCRPVKWHS-GQVPIAKRVFKLRVA 615
            ..|:  ::.|  :.:..:  .|.        ||::|  |..|....|.: .:....::|.:....
Zfish   519 PGYRKAVRHG--QSLCCFDCVPCDIGKISNETDSVD--CLSCPEDYWSNVNRTECIQKVIEFLSH 579

  Fly   616 TIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVY-ATVILLGL 679
            ....:   |:..::..|..|.|..|...|:.:....:::::.:||....|...|.: ..:|.:|
Zfish   580 DAMGM---TLTVIAVAGAFLTITVLGIFLYNKGTPIVRVNNSELSFFILVSLTFCFLCALIFIG- 640

  Fly   680 DHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQDIQLI 742
                     :..:..|..|....|..|||....:..||..|...|  ||.|:... |.|...|..
Zfish   641 ---------EPTSWSCMLRHTAFSITFSLCISCILGKTLVVLAAFTATRPGNNIM-KWLGPTQQR 695

  Fly   743 LLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEV--CRSQHTQTWLSVLY 805
            :::....||..|:.|:|:|..|...:            |:..||....:  |.......:..||
Zfish   696 IIIFCCTLVQVLICTVWLVVSPPFPY------------RNTKYQQSKIILDCSVGSDLAFWCVL- 747

  Fly   806 AYKGLLLVVGVYMAWETRHVKIPA-LNDSQYIGVSVYSVVI--TSAIVVVLANLISERVTLAFIT 867
            .|.|||..|..::|:..|  |:|. .|:::||   .:|::|  |..:..|.|.:.|.......:.
Zfish   748 GYIGLLACVCFFLAFLAR--KLPGNFNEAKYI---TFSMIIFCTVWLAFVPAYVSSPGKFTTAVE 807

  Fly   868 ITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVV 918
            |.|::.:|....|| ||.||.:.|.              :|.|.||::.::
Zfish   808 IFAILASSFGLLLC-LFAPKCYIIL--------------VKPEKNTKQHLI 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	111/551 (20%)
		ANF_receptor	174..568	CDD:279440	98/487 (20%)
		7tm_3	633..889	CDD:278433	66/263 (25%)
olfcv1	XP_021328990.1	Periplasmic_Binding_Protein_Type_1	34..502	CDD:324556	104/502 (21%)
		NCD3G	510..562	CDD:311495	10/55 (18%)
		7tmC_V2R_pheromone	582..832	CDD:320410	69/296 (23%)
		TM helix 1	582..606	CDD:320410	5/26 (19%)
		TM helix 2	618..639	CDD:320410	5/20 (25%)
		TM helix 3	648..672	CDD:320410	7/23 (30%)
		TM helix 4	696..712	CDD:320410	4/15 (27%)
		TM helix 5	739..765	CDD:320410	8/26 (31%)
		TM helix 6	773..796	CDD:320410	7/25 (28%)
		TM helix 7	801..826	CDD:320410	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910