DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R3 and LOC100498444

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_031751053.1	Gene:	LOC100498444 / 100498444	-ID:	-	Length:	1008	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	179/895 - (20%)
Similarity:	314/895 - (35%)	Gaps:	278/895 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 AATMAVEHINRK-RLLPGYTL--------ELVTNDTQ------CDPGVGVDRFFHAIYTQPSTRM 226
            |...||:.|||. .:||..||        ..|.|..|      ..||..|..:    ..:...|:
Frog    73 AFIFAVDEINRNPAILPNVTLGYHIFDSCRNVNNAMQDVFSILSGPGETVPNY----SCREQHRV 133

  Fly   227 VMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRK 291
            ...:|...:|.:..:|:::..:...|:|:|:|...|||:|.:|.|:||:..|.:...|....:|.
Frog   134 AGFIGDLFTETSLPIAQLLRPYGYSQISYGATDHLLSDKRFYPAFFRTLPNDQTQYQAIAKLLRH 198

  Fly   292 FGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITF--AATDFKEQLLL-----LRETDTR 349
            .||..|.....::::......:|...|....|....|::.  .....:::|..     ||:|.:|
Frog   199 LGWNWVGIIRSDDDIGEQLSRDLSKVLGEYGICIEYTLSIPEEQNPRRDELYARLQGKLRQTTSR 263

  Fly   350 IIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVV-- 412
               |:        ::|.  |:.:|   |...|....|:                 .:|.:::|
Frog   264 ---GA--------VMCS--RVSLF---YMNSLTREEGS-----------------LLEKILIVPV 295

  Fly   413 -------STHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHG--------------QDGFGSGYGS 456
                   ||..|:   ...|:|.   :|..:..|...:.|.              :|.|.:.:..
Frog   296 NWNYRPYSTARSL---RTLYNGT---LFFKRPSKNLPRLHRLLENLNRTKGDKMLEDIFATYFNC 354

  Fly   457 RISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQ-----YAPQT-------YDAVWAIALALR-- 507
            ..|:....:..:......:|..||    .|.|:|     |...|       |.||:|:|.||.
Frog   355 LTSVPLRNTMIQTIYPLVLGNCSG----KEKITQLKRKGYNTVTFRTTYHVYKAVYAMAYALHHM 415

  Fly   508 ---------------------------------AAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQ 539
                                             ..|.:::.|.|.|.:           :..|||
Frog   416 LLPRGPPHLHTGAHIHRERFRHFLTKVHFKDPTGEEIYFKENGEMSSV-----------YHLLQQ 469

  Fly   540 MGKLHFLGVS-----GPVSFSGPDR----VGTTAFYQIQRGLLEPVALYYPATDALDFRCP---- 591
            :..::  |.:     |..:.|.|:.    :....|.....|...||:...|       |||
Frog   470 INWVN--GTTELRHVGTFNSSAPEEEQLIIAHRGFMWHLDGSGIPVSRCTP-------RCPPGQR 525

  Fly   592 ------------------------------RCRPV---KWHSGQ----VPIAKRVFKLRVATIAP 619
                                          .|:|.   ||.:.:    :|.:......: :....
Frog   526 KLPRRGQQHACCYDCVQCSEGMISNDTDREACQPCPEDKWPNQKKDQCLPRSSEFLSYQ-SDWKT 589

  Fly   620 LAFYTIATLSSVGIALAIA-FLAFNLHFRKLKAIKLSSPKLSNITAVG-------CIFVYATVIL 676
            |.|..::.|.|...|:.:. |:|    ||....:|.::.:|| ...:|       |:|::
Frog   590 LLFSIVSILLSGVTAIIVGIFVA----FRHSPIVKANNQRLS-FLLLGSIMMSFLCVFLF----- 644

  Fly   677 LGLD-HSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQD 738
            ||.. |.|           |..|...:...||:...|:.|||..|..:|  ::.|:.:|..:...
Frog   645 LGRPLHVT-----------CMLRQTCMGIIFSVVVSSVLAKTIMVCIVFKASKPGNYWKKCVGAK 698

  Fly   739 IQLILLVGGLLLVDALLVTLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSV 803
            |...::|...||..::.:. |:...|....|          :||...:..:: |.......:.:|
Frog   699 IPNGVVVACSLLQVSISIA-WLSISPPFMEL----------NRSFPGKILIQ-CNEGSPVAFYAV 751

  Fly   804 LYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITSAIVV--VLANLISERVTLAF 865
            | .|.|||..|...:|:..|  |:| :.|:::||   .:|:::..::.|  :.|:|.........
Frog   752 L-GYLGLLAAVSFIVAFLAR--KLPDSFNEAKYI---TFSMLVFCSVWVSFIPAHLSVTGKNTVV 810

  Fly   866 ITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRR 915
            :.|.| |:.|:...|..:|.||.:.|.              :|.|.||:|
Frog   811 VEIFA-IMASSFGVLASIFFPKCYIIL--------------IKPEQNTKR 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	98/513 (19%)
		ANF_receptor	174..568	CDD:279440	94/491 (19%)
		7tm_3	633..889	CDD:278433	63/269 (23%)
LOC100498444	XP_031751053.1	Periplasmic_Binding_Protein_type1	34..504	CDD:415822	94/490 (19%)
		NCD3G	512..566	CDD:400103	9/60 (15%)
		7tmC_V2R_pheromone	592..836	CDD:320410	66/283 (23%)
		TM helix 1	592..612	CDD:320410	5/19 (26%)
		TM helix 2	624..645	CDD:320410	5/26 (19%)
		TM helix 3	654..676	CDD:320410	6/21 (29%)
		TM helix 4	702..718	CDD:320410	3/16 (19%)
		TM helix 5	744..767	CDD:320410	7/23 (30%)
		TM helix 6	779..801	CDD:320410	5/24 (21%)
		TM helix 7	806..831	CDD:320410	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D590810at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010