DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and npr3

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_004910476.1	Gene:	npr3 / 100495974	XenbaseID:	XB-GENE-1012470	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	102/523 - (19%)
Similarity:	173/523 - (33%)	Gaps:	151/523 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINR-----KRLLPGYTLELVTNDTQCDPGVGVDRFFHAI-----YTQPSTRMVMLLGSACS 235
            ||:|..|     :.||||....::.||:.|    |....|..|     ..:|.    ::||..|.
Frog    49 AVDHALRSIQENQTLLPGMHFNVIYNDSDC----GNQALFSLIDIAMQLQKPD----VILGPVCE 105

  Fly   236 EVTESLAKVVPYWNIVQVSFGSTSPALSDR-REFPYFYRTVAPDSSHNPARIAFIRKFGW----- 294
            .....:|::..:||:..:|.|:.:.....: .|:.:..|.....|......:|..|...|
Frog   106 YAAAPVARLASHWNVPMLSAGALAIGFMQKSNEYSHLTRVSPVYSKMGEMFLAMFRYHKWTKAFL 170

  Fly   295 ----------------GTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLL 343
                            |....|  .||.::::::|..   |..::..            |:::..
Frog   171 LYTDDNLQRNCFFTLEGVHLAF--KEEGYAMSIHNFD---ETKHVDA------------EEIVHS 218

  Fly   344 RETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVEN 408
            .:...|::|...|.:....|:..|:|..|...||.:.                  |.||
Frog   219 IQNKERVVIMCASSDTVRNIMLAAHRQGMTNGDYVFF------------------NIEL------ 259

  Fly   409 LIVVSTHNSIVGN-------------NVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISI 460
                 .::|..||             ..:||.|..   .:.||....:|   :.|.....|.:..
Frog   260 -----FNSSTYGNGSWKRGDKYDLEAKQAYSSLQT---VTLLRTVKPEF---EKFSMEVKSSVQK 313

  Fly   461 AATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGF 525
            .....|                   :.::.:....:||:...||||     |.......||.||
Frog   314 LGLNED-------------------DYVNMFVEGFHDAIILYALAL-----HELLKNGFSKKDG- 353

  Fly   526 DYTRSDMAWEFLQQMGKLHFLGVSGPVSF-SGPDRVG---TTAFYQIQRGLLEPVALYYPATDAL 586
                    .:.:|||....:.|::|.||. :..||.|   ..|....:.|..|.:..||......
Frog   354 --------EKLVQQMWNRTYEGIAGQVSIDANGDRYGDFSVIAMTDKETGTQEVIGDYYGIQGHF 410

  Fly   587 DFRCPRCRPVKWHSGQVPIAKRVFKLRVAT-------IAPLAFYTIATLSSVGIALAIAFLAFNL 644
            :.| |..:| .|..|::.|.:|:.:....|       :...|...|...:.:|..|.:||..|..
Frog   411 EIR-PNVKP-PWGPGRLLINERIVEHPSTTPCKSSGGLGESAVTGIVVGAFLGTGLLMAFYFFRK 473

  Fly   645 HFR 647
            .:|
Frog   474 KYR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	86/457 (19%)
		ANF_receptor	174..568	CDD:279440	82/435 (19%)
		7tm_3	633..889	CDD:278433	5/15 (33%)
npr3	XP_004910476.1	PBP1_NPR_C	25..414	CDD:380609	87/458 (19%)
npr3	XP_004910476.1	TM_EphA1	443..474	CDD:391457	7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910