DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and LOC100490381

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:XP_017945227.2 Gene:LOC100490381 / 100490381 XenbaseID:XB-GENE-29080167 Length:441 Species:Xenopus tropicalis


Alignment Length:360 Identity:87/360 - (24%)
Similarity:141/360 - (39%) Gaps:93/360 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   590 CPRCRPVKWHSGQVPIAKRVFKLRVAT-----IAPL--AFYTIATLSSVGIALAIAFLAFNLHFR 647
            |.:|...:|     |..||...::..|     ..||  :...::.|||:.:.|  .||.| |.:.
 Frog   145 CIQCPEDQW-----PNDKRTICIQKITEFLSYEDPLGQSLAAVSVLSSLTVIL--VFLIF-LKYH 201

  Fly   648 KLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTL--------PSAEDSFATVCTARVYLLSA 704
            |...:|.::..||          |:  :||.|..|.|        |.     ...|..|......
 Frog   202 KTPVVKANNQTLS----------YS--LLLSLTLSFLCCFLFIGRPQ-----KVTCLLRQVTFGI 249

  Fly   705 GFSLAFGSMFAKTYRVHRIF--TRTGSVFKDKMLQDIQL-ILLVGGLLLVDALLVTLWVVTDP-- 764
            .|:::...:.|||..|...|  |:.||..|..:...:.| ::|:..||.|...||  |:::.|  
 Frog   250 NFTVSVSCVLAKTVTVVIAFNATKPGSKIKKWVGTRVSLCLVLLCSLLQVGICLV--WLISSPPF 312

  Fly   765 --MERHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLY---AYKGLLLVVGVYMAWETRH 824
              .:.|.:...:.:...:.||                  |..|   .|.|.|..:...:|:..| 
 Frog   313 PDYDTHTYTGKMILQCNEGSV------------------SAFYTVIGYIGFLSGLSFIVAFLVR- 358

  Fly   825 VKIPA-LNDSQYIGVSVYSVVITSAIVV--VLANLISERVTLAFITITALILTSTTATLCLLFIP 886
             |:|| .|::|.|   .:|:::..::.|  :.|.|.::...:..:.|.| ||.|:...|..:|||
 Frog   359 -KLPASFNEAQLI---TFSMLVFCSVWVSFIPAYLSTKGKYMVAVEIFA-ILASSAGLLGCIFIP 418

  Fly   887 KLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDR 921
            |.:.|..|              .|.||||.:...|
 Frog   419 KCYIILFR--------------PEQNTRRGLTGKR 439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 3/9 (33%)
7tmC_GABA-B-like 621..892 CDD:320175 70/291 (24%)
TM helix 1 621..645 CDD:320175 7/23 (30%)
TM helix 2 657..678 CDD:320175 4/20 (20%)
TM helix 3 696..720 CDD:320175 5/23 (22%)
TM helix 4 741..761 CDD:320175 8/20 (40%)
TM helix 5 797..823 CDD:320175 6/28 (21%)
TM helix 6 832..855 CDD:320175 4/24 (17%)
TM helix 7 862..887 CDD:320175 8/24 (33%)
LOC100490381XP_017945227.2 Periplasmic_Binding_Protein_type1 <22..93 CDD:471960
NCD3G 101..154 CDD:462210 3/13 (23%)
7tmC_V2R_pheromone 174..425 CDD:320410 73/296 (25%)
TM helix 1 174..199 CDD:320410 9/27 (33%)
TM helix 2 211..232 CDD:320410 8/32 (25%)
TM helix 3 241..265 CDD:320410 5/23 (22%)
TM helix 4 289..305 CDD:320410 6/17 (35%)
TM helix 5 332..358 CDD:320410 8/43 (19%)
TM helix 6 366..389 CDD:320410 5/25 (20%)
TM helix 7 394..419 CDD:320410 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

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