Protein Alignment GABA-B-R3 and XB991396

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_002938346.1
• Gene: XB991396 / 100487890
• XenbaseID: XB-GENE-991397
• Length: 924
• Species: Xenopus tropicalis
• Alignment Length: 1040
• Identity: 209/1040 - (20%)
• Similarity: 361/1040 - (34%)
• Gaps: 315/1040 - (30%)

  Fly   141 MSPAEM--QRNHGKIVLLGLFE-----------------LSTSRGPRPDGLSELGAATMAVEHIN 186
            ::|.::  .::||.|::.|||.                 :....|....|..::.|.:.|:|.||
 Frog    21 LTPDDLIGAKSHGDIIIGGLFSVHGKMMNSPTGYPNIPAIQNCSGFEMQGFLQMLAMSHAIEMIN 85

  Fly   187 RKRLLPGYTLELVTNDTQCDPGVGVDRFFHAI---------------YTQPSTRMVMLLGSACSE 236
            ...|:||..|.....||..:..:.:......:               ||..:.::..::|.:.||
 Frog    86 NSPLIPGIRLGYEIYDTCSEVTMALSATMRLLSEFNSSEDNLKIKCNYTTYTPKVKAIIGDSYSE 150

  Fly   237 VTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFS 301
            |:.::|:::....|..||..|::..|||:..||.|.||:..|.....|....|...||..:...:
 Frog   151 VSIAVARLLNTQLIPLVSHSSSAEILSDKFRFPTFLRTIPNDFHQTRAMAKLIHFSGWNWIGLIA 215

  Fly   302 QNEEVHSLAVNNLVTELEAANISCA---------ATITFAATDFKEQLLLLRETDTRIIIGSFSQ 357
            .::|....|:.:...:....|:..|         :..|..:...|..:.:||||...||:.....
 Frog   216 MDDEYGRSALESFGAQSMKINVCIAFKHIIPAHLSDSTVQSKINKTIMTILRETRVNIIVVFLKP 280

  Fly   358 ELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNN 422
            .|..::..:..:|.:   ...||     .:..|....|..|...:|.              ||..
 Frog   281 SLVIRLFKKVIQLNI---QKTWI-----ASDMWSAASTISSIPNIQR--------------VGRV 323

  Fly   423 VSYSGLNNHM--FNSQLRKQSAQF----HGQDGFG-----------SGYGSRISIAATQSDSRRR 470
            :.::..:.:|  |.:.|:..::|.    |..|.:.           :...|.||..:.::....:
 Frog   324 IGFTFKSGNMSPFLNYLKNLNSQHFEMNHLLDQYAWLLYHCPKVKYNELSSCISNYSKETPYDIK 388

  Fly   471 RRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWE 535
            .|:|: ......|.......:...|..||.|||.|:|    :...|......|.|      ..||
 Frog   389 NRKGI-FLKEDFLLESMQPGFVYSTQLAVTAIAYAIR----NICSNRNCKDPDAF------APWE 442

  Fly   536 FLQQMGKLHFLGVSGPVSFSG-----PDRVGTTAFYQIQRGL--------LEPVALYYPATDALD 587
            .||.:..::|       :|.|     ..|......|.:...:        :.|||.|....|:..
 Frog   443 LLQGLKTVNF-------TFDGRNIYFDSRGDANTGYDVLMWMVGDDGRIDITPVAEYDSQKDSFL 500

  Fly   588 FR-----------------C-PRCRPVKWHSGQVPIAKRVFKLRVATIAPLAFYTIA-------T 627
            |:                 | .:|:|     ||:       |...|::....:..:|       .
 Frog   501 FKNTEKENEFIRLKKIESTCSDQCKP-----GQM-------KKTSASLHTCCYECVACPENHHTN 553

  Fly   628 LSSVG-----------------------------------IALAIAFLAFNLHFRKLKAIKLSSP 657
            .|.:|                                   |.|.::||...|    :.||.|...
 Frog   554 KSDMGYCLQCNNKTEWSPVNSSVCYNKDIKYLRWNDGFAIILLIVSFLGKGL----IIAIALLFT 614

  Fly   658 KLSN---ITAVGCIFVYATVILLGLDHSTLPSA------ED------------SFATVCTARVYL 701
            |..|   :.|.|.|..|  ||||.:..|.:.:.      ||            || ||..|.::|
 Frog   615 KNFNTPVVKASGGILCY--VILLSIFFSFVSAVFFIGKPEDFKCKVRQTLFGISF-TVVVACIFL 676

  Fly   702 LSAGFSLAFGSMFAKTYRV----HRIFTRTGSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVT 762
            .|....||| |...:..|:    |:.||               |:.:..|   :..|:...|:|.
 Frog   677 KSVKILLAF-SFEPRVQRILRLLHKPFT---------------LVFICTG---IQVLICATWLVF 722

  Fly   763 DPMERHL-HNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVK 826
            .|  .|: .|.:|     .::::|:     |....|..: ||:..|..:|..:....|::.|  |
 Frog   723 WP--PHMKENFSL-----PQTIIYE-----CDEGSTIAF-SVMLVYIAVLAFICFIFAFKGR--K 772

  Fly   827 IPA-LNDSQYI--GVSVYSVVITSAIVVVLANLISERVTLAFITITA-------------LILTS 875
            :|. .|::::|  |:.:||:                 ..:.||.|.|             :||.|
 Frog   773 LPENYNEAKFITFGMLIYSI-----------------AWITFIPIYATTFGIYLPAVEMIVILIS 820

  Fly   876 TTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDDRRELQYRVEVQNRVYKKEIQ 940
            :...|...|.||.:.|.              .|.:.||:...:    ::.|:...::.......|
 Frog   821 SYGILTCTFFPKCYIIL--------------YKQDSNTKTAFL----KMIYKYSSKSASNLTISQ 867

  Fly   941 ALDAEIRKLERLLESGLTTTSTTTSSSTSLL--TGGGHLKPELTVTSGI--SQTPAASKNRTPSI 1001
            |..:.:     :|||..:.:....|::.|.:  |...|   |..||:.|  |.|...::.|..||
 Frog   868 ASSSSV-----VLESSSSASDVYVSTTLSCISNTFSFH---ERLVTTDIPSSHTGLPTRKRLSSI 924

  Fly  1002  1001
             Frog   925  924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	100/520 (19%)
		ANF_receptor	174..568	CDD:279440	89/439 (20%)
		7tm_3	633..889	CDD:278433	72/297 (24%)
XB991396	XP_002938346.1	Periplasmic_Binding_Protein_Type_1	36..503	CDD:299141	100/506 (20%)
		ANF_receptor	74..476	CDD:279440	89/441 (20%)
		NCD3G	517..569	CDD:284890	10/63 (16%)
		7tm_3	605..835	CDD:278433	68/287 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910