Protein Alignment GABA-B-R3 and gucy2g

DIOPT Version :9

• Sequence 1: NP_001245826.1
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: XP_009305067.2
• Gene: gucy2g / 100333350
• ZFINID: ZDB-GENE-130531-70
• Length: 1127
• Species: Danio rerio
• Alignment Length: 1235
• Identity: 223/1235 - (18%)
• Similarity: 394/1235 - (31%)
• Gaps: 369/1235 - (29%)

  Fly   157 GLFELSTS-RGPR----PDGLSELGAA-TMAVEHINRKRLLPG-YTLELVTNDTQCDPGVGVDRF 214
            |.|:|:.. :.||    |..|..||:| .:|::.||....|.| :|.:.|..||.|:....:..|
Zfish    32 GQFKLTVGLQAPRNISYPFSLLRLGSAMQIAMDKINSNPALSGNFTFDFVYMDTDCNAKTSLRGF 96

  Fly   215 FHAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDS 279
            ...:..|   .:..|.|..|.|..|....:...|||....|...:|.:.:.:.:..:.:.|.|..
Zfish    97 IEQVMEQ---NVSALFGPPCPEEAEVTGLIASTWNIPMFGFVGQTPKMDNIQVYDTYIKIVPPLK 158

  Fly   280 SHNPARIAFIRKFGWGTVTTFSQNEEVHSL----AVNNLVTELEAANISCAATITFAATDF---K 337
            ......:..:..|||..|.......:.::.    |:...|.:...:.::....|.|..:|.   |
Zfish   159 RVGEILLKALEFFGWKHVGMIGGGADANTWDSVEALWKSVDQQLRSKVTVTMGIKFDTSDLEQAK 223

  Fly   338 EQLLLLRETDTRIIIGSFSQELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQ--RTACS-- 398
            ..|.::.:. .|:::...:.|.:..::.||.:|.:...:|.::|.:........|.  :|:.|
Zfish   224 RNLQIISKV-ARVVVVLANAEDSTAMMIEAQKLGLMSGEYVFLLVQQFEVSGKVDNLWKTSVSET 287

  Fly   399 NHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAAT 463
            |..:..|.:.:.|::        ..||.|.:.:.|..|...:..        |..:.|.:|..
Zfish   288 NRTMLKAFDMVFVLA--------EKSYDGYDYYDFFDQAYDKLK--------GDPFYSNLSSV-- 334

  Fly   464 QSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYT 528
                                  :.:|.||...:|||...|:.|:.|.:           .|.|..
Zfish   335 ----------------------KEVSSYAAYLHDAVLLYAMGLKEAFK-----------SGKDIR 366

  Fly   529 RSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTT----AFYQIQR-----------------GL 572
            ......:.|:....:.|.|.||.|.|   |..|..    :.|.:|:                 .:
Zfish   367 HGREIVQKLRDRTSIRFYGASGLVHF---DEYGERNLDYSVYDLQQTETLIQFVSVLDFDSHTKM 428

  Fly   573 LEPVALY--------YPATDALDFRCPRC----RPVKWHSGQVPIAKRVFKLRVATIAPLAFYTI 625
            ::|...:        .|.||.     |.|    ...:|...::.:...:..|.:..:|.::..|:
Zfish   429 IKPTLRFSNIVWQNGKPPTDN-----PSCGFDNELCEWLDNEISLLVLLVALPLIGVAAVSLITL 488

  Fly   626 ATLSSVGIALAIA----FLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPS 686
            .||..:.:...:.    :|   :::..:..::  .||.:.|.:|                :|.||
Zfish   489 LTLQKLRLQSRLDESNWWL---INYSDITILR--EPKGTQILSV----------------NTTPS 532

  Fly   687 AEDS-------FATVCTAR--VYLLSAGFSLAFGSMFAKTYRVHRI---FTRTGSVFKDKMLQDI 739
            ...|       .:..|..|  :|   |...|..|:.....|..::|   ..:...:.:..||:::
Zfish   533 KCGSGGSQSMLSSNSCNTREAIY---ATVGLFQGNEVGIKYLKNQIIPDIKKPSIIAEFNMLKEM 594

  Fly   740 Q---LILLVGGLL----------------LVDAL------------LVTLWVVTDPMERHLHNLT 773
            :   |:...|..:                |.|.|            |...:.:.:.|| ::|..:
Zfish   595 KHENLVQFFGVCIDPPNVCIVMQYCKKGSLKDVLGNHEIDLDWMFKLSFAYDIVNGME-YIHKSS 658

  Fly   774 LEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWE----TRHVKIP------ 828
            |:                   .|.....|.......|.:.:..:..||    |:|..||
Zfish   659 LK-------------------SHGNLRPSTCLVDSRLQIKLSGFGLWEFKCGTKHRLIPLDSPKY 704

  Fly   829 ----------------ALNDSQYIGVSVYSVVI------------------TSAIVVVLANLISE 859
                            ..|.:|...|..::::|                  ...|:..|...:||
Zfish   705 EEMYWTAPEFLREIFYPFNGTQKGDVYSFAIIIRELIYSTEVGPYHDVHLEPKEIIKQLRTPMSE 769

  Fly   860 ---RVTLAFITITALILTSTTATLC-LLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVVDD 920
               |.||             :|.:| ...||.:...|:.|....|...|:
Zfish   770 EPLRPTL-------------SADICDERLIPLIKACWSENPDHRPPFGSI--------------- 806

  Fly   921 RRELQYRVEVQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTS 985
            ||:|      ::...:.....||..:.|||:.                     ..||  |..|..
Zfish   807 RRQL------RDACPESHANILDNMVNKLEKY---------------------ANHL--EEVVEE 842

  Fly   986 GISQTPAASKNRTPSISGILPNLLLSVL---PPVIPRASWPSAEYMQIPMRRSVTFASQPQLEEA 1047
            ..||...........:|.:||..:...|   ..|.||    |.|.:.|.....|.|.:...:..|
Zfish   843 RTSQLTVEKSRADKLLSSMLPRYIADQLMAGKSVEPR----SYEMVTIFFSDIVGFTTMCSVSSA 903

  Fly  1048 CLPA----------QDLINLRLAHQQATEAKTGLINRLRGIFSRTTSSNKGSTASLADQKGLKAA 1102
            ....          .|:|.|...::..|.....::.....|.:.|..:.:.||.:|.....:| .
Zfish   904 LEVVTLLNDLYSLFDDIIKLYDVYKVETIGDAYMVASGLPISNGTLHAEEISTMALHFLSSIK-R 967

  Fly  1103 FKSHMGLFTRLIPSSQTASCNAIYNNP---------------NQDSIPSEASSHPNGNHLKPIHR 1152
            ||      .|.:|:.:.|....|.:.|               ..|::.:.:....|...||
Zfish   968 FK------IRHLPNERLALRIGINSGPVVAGVVGSTMPRYCLFGDTVNTASRMESNSLPLK---- 1022

  Fly  1153 GSLTKSGTHLDHLTKDPNFLPIPTISGGEQGDQTLGGKYVK---LLETKVNFQLP-----SNRRP 1209
                   .|:...|.| ..|.|.|....|:||..:.||..:   .|.:|..|..|     ||..|
Zfish  1023 -------IHISQSTAD-ILLTIGTFELEERGDIEIKGKGTQKTFWLLSKPGFTFPPTGQDSNPSP 1079

  Fly  1210  1209
            Zfish  1080  1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	92/479 (19%)
		ANF_receptor	174..568	CDD:279440	80/410 (20%)
		7tm_3	633..889	CDD:278433	53/350 (15%)
gucy2g	XP_009305067.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910