Protein Alignment GABA-B-R3 and olfcg4

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001122034.1
• Gene: olfcg4 / 100148438
• ZFINID: ZDB-GENE-060503-66
• Length: 835
• Species: Danio rerio
• Alignment Length: 916
• Identity: 178/916 - (19%)
• Similarity: 317/916 - (34%)
• Gaps: 268/916 - (29%)

  Fly   150 HGKIVLLGLF---------ELSTSRGPRPDGLSELG------AATM--AVEHINR-KRLLPGYTL 196
            :|.|.:..||         .|..:|.|:|...|.:.      |..|  |:|.||: :.|||..|:
Zfish    37 NGDITIGALFPIHSTETLTSLKFTRKPQPISCSSVNLRDFRLAEIMIFAIEEINKSESLLPNVTI 101

  Fly   197 ELVTNDTQCDPGVGVDRFFHAIYT----------QPSTRMVMLLGSACSEVTESLAKVVPYWNIV 251
            .....|| |...:........:..          :..|.:..::|.:.|..|..|.:....:.|.
Zfish   102 GYQVYDT-CGSRLSTMSAIMGLMNSQGFDAEDGCKGQTPIQAIIGDSESSATVILTRTTGPFKIP 165

  Fly   252 QVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLVT 316
            .:|..::...||:|.::|.|:||.|.|...:.|.:..::..||..:...|.:.:..:..::....
Zfish   166 VISHSASCECLSNRNDYPSFFRTTASDYHQSRALVHIVKHLGWTWLGAVSSDNDYGNYGMSIFQK 230

  Fly   317 ELEAANISCAATITFAATDFKEQLLLLRET---DTRIIIGSFSQELAPQILCEAYR------LRM 372
            ..:...|....::.|..|: :|:|..:.||   .|..:|.:|...|...:|.:...      |:|
Zfish   231 IAQEEGICMEYSVKFYRTE-QEKLQKVVETMKKGTAKVIVAFVSFLEMGLLIDQLSVQNITGLQM 294

  Fly   373 FGADYAWILHESMGAPWWPDQRTACSNHELQLAVENLIVVSTHNSIVGNNVSYS-------GLNN 430
            .|.. :||..|:...|                       .|.|  ::|.::.::       |.::
Zfish   295 IGVK-SWITSENYITP-----------------------KSFH--VLGGSLGFAMRKMYIEGFSD 333

  Fly   431 ---------HMFNSQLRKQSAQFHGQDGFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPE 486
                     |...||.:..::.:...   .|.|...:.:...:.|....|
Zfish   334 FALKTFWEKHFQCSQTKPNASNYASS---CSRYNDLLMLKNYKEDVTEHR--------------- 380

  Fly   487 AISQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGP 551
                |:...|:||:|:|.:|.:.    .:.:|:.|.:.....:.....|.|:   |::|     .
Zfish   381 ----YSSNVYEAVYAVAYSLHSL----LKCKERVKCEKGMTIQPQQVVEALK---KVNF-----S 429

  Fly   552 VSFSGPDRV------GTTAFYQI--------------------------QR------------GL 572
            |.|.  |||      .|.|.|::                          ||            |:
Zfish   430 VKFG--DRVWFDSTGSTVAQYEVVNWQRISDESFQFKTVGYYDASLPPNQRFLLNTENIIWAGGM 492

  Fly   573 LE----------------------PVALY--YP------ATDALDFRCPRCRPVKWHSGQVPIAK 607
            ||                      |...|  .|      :||.....|.:|....|.:.:.  .|
Zfish   493 LEKPRSVCSESCPPGTRKASQKGRPACCYDCIPCAEGEISTDTDSNNCKQCPGEYWSNDKK--NK 555

  Fly   608 RVFKLRVATIAPLAFYTI-------ATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAV 665
            .|.|    .:..|:|..:       .:|..||:...:|.|.:|.  :....::.::.:||.:...
Zfish   556 CVLK----AVEFLSFTEVMGVLLLFVSLFGVGLTTLVAILFYNK--KDTPIVRANNSELSFLLLF 614

  Fly   666 GCIFVY-ATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRVHRIF--TRT 727
            ..|..: .::..:|      ...|.|    |..|.......|.|....:..||..|...|  |..
Zfish   615 SLILCFLCSITFIG------RPTEWS----CMLRHTAFGITFVLCISCVLGKTIVVLMAFKATHP 669

  Fly   728 GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERHLHNLTLEISATDRSVVYQ 786
            ||... |....:|..|.|.....:..::..||:...|      |:.:...:.||.|.  .|:|
Zfish   670 GSNVM-KWFGPVQQRLSVLVFTFIQVIICVLWLTISPPFPYRNMKYYKEKIILECSL--GSIV-- 729

  Fly   787 PQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITSAI- 849
                       ..|  .:..|.|||..:...:|:..|  |:| ..|::::|   .:|::|..|:
Zfish   730 -----------GFW--AVLGYIGLLAALCFILAFLAR--KLPDNFNEAKFI---TFSMLIFCAVW 776

  Fly   850 VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECN 912
            :..:....|.  ::|:| :.|.| ||.|:...|..:|.||.:.|..              |.|.|
Zfish   777 ITFIPAYFSSPGKLTVA-VEIFA-ILASSIGLLFCIFAPKCYIILC--------------KPEQN 825

  Fly   913 TRRFVV 918
            |::.::
Zfish   826 TKQHIM 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	104/570 (18%)
		7tmC_GABA-B-like	621..892	CDD:320175	63/290 (22%)
		TM helix 1	621..645	CDD:320175	7/30 (23%)
		TM helix 2	657..678	CDD:320175	3/21 (14%)
		TM helix 3	696..720	CDD:320175	5/23 (22%)
		TM helix 4	741..761	CDD:320175	4/19 (21%)
		TM helix 5	797..823	CDD:320175	6/25 (24%)
		TM helix 6	832..855	CDD:320175	4/23 (17%)
		TM helix 7	862..887	CDD:320175	9/24 (38%)
olfcg4	NP_001122034.1	Periplasmic_Binding_Protein_type1	42..488	CDD:471960	93/509 (18%)
		NCD3G	496..549	CDD:462210	7/52 (13%)
		7tmC_V2R_pheromone	570..819	CDD:320410	62/285 (22%)
		TM helix 1	570..594	CDD:320410	5/23 (22%)
		TM helix 2	606..627	CDD:320410	3/20 (15%)
		TM helix 3	636..660	CDD:320410	5/23 (22%)
		TM helix 4	684..700	CDD:320410	2/15 (13%)
		TM helix 5	727..753	CDD:320410	8/40 (20%)
		TM helix 6	761..784	CDD:320410	4/25 (16%)
		TM helix 7	789..814	CDD:320410	9/26 (35%)