DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and Vmn2r130

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001371191.1	Gene:	Vmn2r130 / 100042225	MGIID:	3761689	Length:	855	Species:	Mus musculus

Alignment Length:	862	Identity:	162/862 - (18%)
Similarity:	283/862 - (32%)	Gaps:	261/862 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINRKR-LLPGYTL-----ELVTNDTQCDPGVGVDRFFHAIYTQPSTRMVMLLGSACSEVTE 239
            ::..:||.. |||..:|     .|..|::|....:.:....|..:.          ...|::...
Mouse    81 SINEVNRNSDLLPNMSLIFTFSALSCNESQLKSFIHLSLQDHDYFP----------NYICNDYIC 135

  Fly   240 SLAKVVPYW----------------NIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAF 288
            .:|.|...|                ..:.:::|...||:||..||||.|:..:.|:|...|.::|
Mouse   136 GVALVGLKWETTLTLYTILNNFMSHQFLFLNYGPFHPAMSDHEEFPYIYQMASEDTSLALAMVSF 200

  Fly   289 IRKFGWGTV-TTFSQNEEVHSLAVNNLVTELEAANISCAATIT---------FAATDFKEQLLLL 343
            |..|.|..| ...|.|:|.... :::|..|:| .|..|.|.::         ...|:.....::.
Mouse   201 IIHFSWNWVGLAISDNDEGIQF-LSHLRREME-KNTVCFAFVSMIPVNMHLYMTRTEVYYNQIMT 263

  Fly   344 RETDTRIIIGSFSQELAPQI-LCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVE 407
            ..|:..||.|.....||... :.|:..::..     |:....     |.
Mouse   264 SSTNVVIIYGDTDSTLAVSFRMWESLDIKRI-----WVTTSQ-----WD---------------- 302

  Fly   408 NLIVVS----THNSIVG------NNVSYSGLNNHMFNSQLRKQSAQFHGQDGFGSGYGSRISIAA 462
              |:.|    |.|::.|      ::...||..|.:....|.|          |...|..::....
Mouse   303 --IITSKKDFTFNNLYGTFAFGHHHGEISGFKNFVQTLDLLK----------FSDEYLVKLEWMY 355

  Fly   463 TQSDSRRRRRRGVGGTSGGH--------LFPEAISQYAPQTYDAVWAIALALRAAEEHWRRNEEQ 519
            ...:....:.:.:...|..|        .|..|.::.:...|:||:|:|.||.........|...
Mouse   356 FNCEDSAPKCKTLKNCSSNHPLEWLMVRTFDMAFTEGSYAIYNAVYAVAHALHELTFQKFDNLRP 420

  Fly   520 SKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRVGTT----------AFY-------- 566
            ..:.|..|..:.:. .||:   |:||   :.||.    |||...          .||
Mouse   421 DNVKGQKYACNKLG-SFLR---KIHF---TNPVG----DRVNMNQRNKLQENYDIFYVWNFPQGL 474

  Fly   567 --QIQRGLLEPVAL----YYPATDALD-----------------------FR-------CPRCRP 595
              :::.|:..|..:    .:.:.|.|:                       ||       |..|||
Mouse   475 RLKVKIGIFSPYFINGQQLHLSEDMLEWARGSTQMLTSVCSADCGPGFRKFRRNGMPACCFDCRP 539

  Fly   596 VKWHSGQVPIAKRVFKLRVATIAPL----------------AFYTIATLSSVGIALAIAFLAFN- 643
                   .|..:...:..|....|.                |...:.....:|:||::..|.|:
Mouse   540 -------CPENEISNETNVELCVPCPEDQYANTEQNNCIQRAVIFLTYKDPLGMALSLMALCFSA 597

  Fly   644 ------LHFRK---LKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARV 699
                  |.|.|   ...:|.::..|:.|..:..||.:...:|. :.|..        :..|..:.
Mouse   598 FTAVVLLVFVKHHSTPIVKANNRTLTYILLISLIFCFLCPLLF-IGHPN--------SVTCVLQQ 653

  Fly   700 YLLSAGFSLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQDIQLILLVGG--------LLLVDALLV 756
            ......|::|..::.|||..:...|..|..       |.:....||.|        ..|:..::.
Mouse   654 VTFGVAFTVAVPTVLAKTITIVLAFRVTAP-------QRMMKYFLVSGASIYIIPICTLIQVIVC 711

  Fly   757 TLWVVTDPMERHLHNLTLEISATDRSVVYQPQVEV-CRSQH-------TQTWLSVLYAYKGLL-- 811
            .:|:...|                      |.|:: .||:|       .:..:|..|...|.|
Mouse   712 AVWLGAAP----------------------PSVDIDARSEHGHIIIVCNKGSVSAFYCVLGYLAC 754

  Fly   812 LVVGVY-MAWETRHVKIPA-LNDSQYIGVSVYSVVITSAIVVVLANLISERVTLAFITITALILT 874
            |..|.: :|:.:|:  :|: .|:::.|..|:  :|..|..|..|....|.:..:.........|.
Mouse   755 LAFGSFTLAFLSRN--LPSTFNEAKSITFSM--LVFCSVWVTFLPVYHSTKGKVMVAVEIFSTLA 815

  Fly   875 STTATLCLLFIPKLHDI 891
            |....|..:|:||.:.|
Mouse   816 SGAGMLICIFVPKCYII 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	95/513 (19%)
		ANF_receptor	174..568	CDD:279440	89/457 (19%)
		7tm_3	633..889	CDD:278433	57/285 (20%)
Vmn2r130	NP_001371191.1	PBP1_pheromone_receptor	42..502	CDD:380588	93/481 (19%)
		NCD3G	511..563	CDD:400103	9/58 (16%)
		7tmC_V2R_pheromone	583..834	CDD:320410	59/292 (20%)
		TM helix 1	584..608	CDD:320410	7/23 (30%)
		TM helix 2	620..641	CDD:320410	5/21 (24%)
		TM helix 3	650..672	CDD:320410	4/21 (19%)
		TM helix 4	698..714	CDD:320410	1/15 (7%)
		TM helix 5	741..764	CDD:320410	6/22 (27%)
		TM helix 6	776..798	CDD:320410	6/23 (26%)
		TM helix 7	803..828	CDD:320410	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910