DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GABA-B-R3 and frs2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001128281.1	Gene:	frs2 / 100038035	XenbaseID:	XB-GENE-479760	Length:	509	Species:	Xenopus tropicalis

Alignment Length:	445	Identity:	85/445 - (19%)
Similarity:	150/445 - (33%)	Gaps:	163/445 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   930 VQNRVYKKEIQALDAEIRKLERLLESGLTTTSTTTSSSTSLLTGGGHLKPELTVTSGISQTPAAS 994
            :|..:....|..::..:  :||..::.|....|..:.:|...:|.|       |.:|..:.|:..
Frog   101 LQEIMQNNSISVVEEPV--VERNPQTELDVPRTPRTPTTPGFSGSG-------VPNGYPRYPSFG 156

  Fly   995 K------NRTPSISGILPNLLLSVLPPVIPRASWPSAEYMQIPMRRSVTFASQPQLEE------A 1047
            :      :|.||:..       :.||.|...::.|    :.:|.....|:.:...::|      .
Frog   157 EASSHPSSRHPSVGS-------TRLPSVGEESTHP----LLVPEDHVHTYVNTSGVQEDQKQRPN 210

  Fly  1048 CLPAQDLI--NLRLAH-------------------------------QQATEAKTGLINRLRGIF 1079
            ..|||::.  ||.:.|                               :|..|.|     :|..:.
Frog   211 IPPAQEVCVSNLEVIHGHSEPAVPERDPQVILEPEGVKFVLGPTPVQRQLMEKK-----KLEKLE 270

  Fly  1080 SRTTSSN----------KGSTASLADQK----GLKAAFKSHMGLFT--------RLIPSSQTASC 1122
            ....|.|          :|.|...:|::    |.|..:::..||..        |::|...|...
Frog   271 QNQASVNNGESSCPNNTEGDTGYDSDERRETPGNKMVYENLNGLSISSSGVRRGRVVPPIPTDIQ 335

  Fly  1123 N---------AIYNNPNQDSIP-----------SEASSHP-----NGNH--LKPIHRGSLTKSGT 1160
            |         |:.|..|..|:|           .:.|..|     ||.|  |.|:|....|::.|
Frog   336 NVNNSAQRRTALINYENLPSLPPVWETRKPSREEDESLGPKTPSLNGFHSNLDPMHNYVNTENVT 400

  Fly  1161 HLDHLTKDPNFLPIPT--ISGGEQGDQTLGGKYVKLLETKVNFQLPSNRRPSVVQ-QPPSLRERV 1222
                       :|:..  :....:.|.|         .|..||.:   ||||:.| |...::..:
Frog   401 -----------VPLSAHKVEFSRRRDCT---------PTVFNFDI---RRPSLEQRQLNYIQVDL 442

  Fly  1223 RG--------SPRFPHRILPPT----CSLSALAESEDRPGDSTSILGSC-KSIPR 1264
            .|        :|:.|...||.|    ..|.|:.:.|     .|:.:.:. |::||
Frog   443 EGGSDSDNPQTPKTPTTPLPQTPTRRTELYAVIDIE-----RTAAMSNLQKALPR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361
		ANF_receptor	174..568	CDD:279440
		7tm_3	633..889	CDD:278433
frs2	NP_001128281.1	PTB_FRS2	15..106	CDD:269913	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910