DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfcj1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001103761.1	Gene:	olfcj1 / 100005028	ZFINID:	ZDB-GENE-060503-724	Length:	857	Species:	Danio rerio

Alignment Length:	913	Identity:	198/913 - (21%)
Similarity:	329/913 - (36%)	Gaps:	273/913 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLFE-----------LSTSRGP-RPDGL--SELG-AATM--AVEHI-NRKRLLPGYTLE 197
            |.:.:.|:|.           |.|:.|. |.:||  .||. |.||  |:|.| ||..||||:.|.
Zfish    37 GNVSIGGVFSFHQNPVGVNPTLRTNPGNIRCNGLDPGELQYAITMIFAIEEINNRTDLLPGFILG 101

  Fly   198 LVTNDTQCDPGVGVDRFFHAIYTQPSTR--------MVMLLGSACSEVTESLAKVVPYWNIVQVS 254
            ....|:.....:.|......:..|..|:        :..::|...|..|..:|:.:..:.|..:|
Zfish   102 YRIYDSCPSIPLSVGASLTLMNGQMETKKSCASPSAVQAVIGETTSTSTIDIARTIGPFKIPVLS 166

  Fly   255 FGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGW---GTVTTFSQNEEVHSLAVNNLVT 316
            ..:|...||:|:::|.|:||:..|...:.|.:..:..|||   |.|.:..      ....|.:.|
Zfish   167 HSATCACLSNRQQYPSFFRTIPSDYYQSRALVKLVTYFGWKWVGAVRSMG------DYGNNGMAT 225

  Fly   317 ELEAA---NISCAATITFAATDFKEQLL----LLRETDTRIIIGSFSQELAPQILCEAYRLRMFG 374
            .||||   .|....:::...|:.:|::|    :::::.:::|:..........::.|.|...:.|
Zfish   226 FLEAAEKEGICVEYSVSIYRTNSREKILEVTDIIKKSTSKVIVAFADGNDLDMLIKELYYQNVTG 290

  Fly   375 ADYAWILHESMGAPWWPDQR---TACS----NHELQLAVENLIVVSTHNSIVGNNVSYSGLNNHM 432
              |.|:     |:..|...|   ||.:    ...:..||.|..:......|.|:..|....|..:
Zfish   291 --YQWV-----GSEGWITYRFLATAINYAVVGGAIGFAVPNAYIPGLKEFITGSQPSLRPGNTGL 348

  Fly   433 -----------FNSQLRKQSAQFHGQDGFGSGYGSRISIAATQ-SDSRRRRRRGVGGTSGGHLFP 485
                       .|||....|...:||:..     :.|:...|. ||
Zfish   349 VELWESVFDCTLNSQTHNASKICNGQESL-----ANINTRFTDVSD------------------- 389

  Fly   486 EAISQYAPQTYDAVWAIALALRAAEE-----------HWRRNEEQSKLDGFDYTRSDMAWEFLQQ 539
               :......|:||:|:|   .|.||           |.:...|:.|:         ..|:.|..
Zfish   390 ---ASLLNNVYNAVYAVA---HAVEELLTCEKGKGPFHKKTCAEKGKI---------QPWQVLYY 439

  Fly   540 MGKLHFLGVSGP-VSFSGPDRVG------TTAFYQIQ-RGLL--EPVALYYPATDALDFRCPRCR 594
            :.:::|...:|. |.|   |:.|      |...:|:. .|::  |.:.||       |...|..:
Zfish   440 LTQVNFTTKNGENVHF---DKHGDPVARYTLVNWQMSYEGIITFESIGLY-------DASKPEGQ 494

  Fly   595 PVK--------WHSGQ--VPIA----------KRVF-----------------KLRVATIA---- 618
            .::        |...|  ||::          ::.|                 :....|.|
Zfish   495 EIQMRDDIEAIWAGNQKKVPLSVCSETCLPGTRQAFVKGKPICCFDCIDCADGEFSNTTNAVTCI 559

  Fly   619 --PLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAV-----GCIFVYATVIL 676
              ||.:.:....:.. :...|.||.||             ..:.||...     ||:.:  ||.|
Zfish   560 PCPLEYKSNGNRTQC-VLKNIEFLTFN-------------EVMGNILVTFSMCGGCLTI--TVGL 608

  Fly   677 LGLDHSTLP-----SAEDSF-----ATVCTARVYLLSAGF------------SLAFGSMF----- 714
            :...|...|     ::|.||     .|:|    :|.|..|            ..|||..|
Zfish   609 IFFYHRHTPIVRANNSELSFLLLFSLTLC----FLCSLTFIGQPTEWSCMLRHTAFGITFVLCIS 669

  Fly   715 ---AKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERH 768
               .||..|...|..|  ||... |.....|..|.|.....:..|:..||:...|      ...:
Zfish   670 CVLGKTLVVLMAFRATLPGSNVM-KWFGPPQQRLSVFVFTFIQLLICMLWLTMSPPFPNKTTNNY 733

  Fly   769 LHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALND 832
            ...:.||                |.|.....:.:|| :|.|.|.::...:|:..|  |:| ..|:
Zfish   734 KDKIILE----------------CDSGSAVGFWAVL-SYIGFLAILCFILAFLAR--KLPDNFNE 779

  Fly   833 SQYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWAR 894
            :::|   .:|::|..|: :..:...||.  :.|:| :.|.| ||.|:...|..:||||.:.|..:
Zfish   780 AKFI---TFSMLIFCAVWITFIPAYISSPGKFTVA-VEIFA-ILASSYGMLFCIFIPKCYIILLK 839

  Fly   895 NDI 897
            .|:
Zfish   840 PDL 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	112/508 (22%)
		ANF_receptor	174..568	CDD:279440	98/452 (22%)
		7tm_3	633..889	CDD:278433	73/302 (24%)
olfcj1	NP_001103761.1	Periplasmic_Binding_Protein_Type_1	35..506	CDD:299141	114/530 (22%)
		ANF_receptor	78..471	CDD:279440	96/447 (21%)
		NCD3G	516..565	CDD:284890	5/48 (10%)
		7tm_3	601..835	CDD:278433	65/264 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910