DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfch1

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001103760.1	Gene:	olfch1 / 100004933	ZFINID:	ZDB-GENE-060503-819	Length:	853	Species:	Danio rerio

Alignment Length:	924	Identity:	177/924 - (19%)
Similarity:	324/924 - (35%)	Gaps:	265/924 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GKIVLLGLFELST-------SRGPRPD-------GLSELG-AATM--AVEHINRKR-LLPGYTLE 197
            |.|::.|.|.:..       |...:|.       .|.||. |.||  |:|.||.|| |||..::.
Zfish    36 GDIIIGGAFSIHNKINLIIPSFTEKPHHLMCTSLNLRELHFAQTMIFAIEEINSKRSLLPNISIG 100

  Fly   198 LVTNDTQCDPGVGVDRFF------------HAIYTQPSTRMVMLLGSACSEVTESLAKVVPYWNI 250
            ....|: |...:...|..            |....:|:.:.:  :|.:.|..|..|::....:||
Zfish   101 YQIFDS-CGSTLASMRSSMALINGQELTAEHTCSGKPAVKAI--IGESESSTTIVLSRAAGPFNI 162

  Fly   251 VQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTTFSQNEEVHSLAVNNLV 315
            ..:|..:|...||.|::||.|:||:..|...:.|....::.|||..:.....:.:..:..:...|
Zfish   163 PVISHFATCACLSSRKQFPSFFRTIPSDYYQSRALAQLVKHFGWTWIGAVRSDNDYGNNGMATFV 227

  Fly   316 TELEAANISCAATITFAATDFKEQLL----LLRETDTRIIIGSFSQELAPQILCEAYRLRMFGAD 376
            ...|...:....:...:.|:.|:::.    ::::...::::...:|.....:|.|..|..:.|..
Zfish   228 EVAEKEGVCIEYSEAISRTNSKDKIAKVVEVIKKGTAKVLMAFLAQGEMDVLLEELIRQNVVGLQ 292

  Fly   377 Y----AWI------------------------------------------LHESMGAPWW----- 390
            :    :||                                          |..::...:|
Zfish   293 WVGSESWITSSYLATERTLNILGGAIGFTIIKSKIPGLKEFLLKVGPSQNLSNALLGEFWEMVFG 357

  Fly   391 ----PDQRTACSNHE---------------------LQLAVEN-------LIVVSTHNSIVGNNV 423
                |   |.|.|.|                     .:|.:.|       .|..:.||:|...|.
Zfish   358 CCLSP---TVCPNSEHATFCDGSENLTNVSNAFTDVSELRISNNVYKAVYAIAYALHNTITCKNS 419

  Fly   424 SYSGLNNHMFNSQLRKQSAQFHG-------QDGFGSGYGSRISIAATQSDSRRRRRRGVG----- 476
            :....|....:..|...|...|.       .|...:.|..:......:.:....::.|.|
Zfish   420 NGGNENITCGDVDLLVSSQVLHSLQNVNFTMDSGETVYFDKNGDPMAKYELVNWQKNGAGETKFI 484

  Fly   477 --GTSGGHLFPEAISQYAPQTYDAVWA-------IALALRAAEEHWRRNEEQSKLDGFDYTRSDM 532
              |.....|..|  .|:...::|.:||       |::...:.:..:|    |:.:.|    |...
Zfish   485 TVGQYDASLSSE--QQFVINSFDIIWAGDSPTKPISVCTESCQPGFR----QAVIKG----RPVC 539

  Fly   533 AWEFLQQMGKLHFLGVSGPVSFSGPDRVGTTAFYQIQRGLLEPVALYYPATDALDFRCPRCRPVK 597
            .:|.||        ..:|.:|                           ..||:.:  |.:| |::
Zfish   540 CFECLQ--------CPAGEIS---------------------------NTTDSAE--CIKC-PLE 566

  Fly   598 WHSGQ---VPIAKRV----FKLRVATIAPLAFYTIATLSSVGIALAIAFLAFNLHFRKLKAIKLS 655
            :.|.:   :.:.|:|    |:..:..:     .|..:|:.|.:.:|:|.:.:.  |.....:|.|
Zfish   567 YWSNKNHSICVLKKVEFLSFEENMGIL-----LTAFSLTGVTLTIAVAIVFYK--FIDTPLVKAS 624

  Fly   656 SPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGSMFAKTYRV 720
            :.:||.:    .:|..:...|..|.....|: |.|    |..|.......|:|....:..:|..|
Zfish   625 NTELSFL----LLFSLSLCFLCSLTFIGRPT-EGS----CMLRHSSFGVTFALCMSCVLTRTIAV 680

  Fly   721 HRIFTRT----GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTD---PMERHLHNLTLEISA 778
            ...|..|    |.......||.|.:....    :...::..||:...   |.:..:::|
Zfish   681 VMAFKTTVPGSGLPHCSLPLQRISVFCCT----VFQVMICILWLALARPMPYKNSMYSL------ 735

  Fly   779 TDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDSQYIGVSVYS 842
             |:.:     :|.........|  .:..|.|||.|:..::|:..|  |:| ..|::::|   .:|
Zfish   736 -DKVI-----LECDLGSAIGFW--AVLGYIGLLSVLCFFLAFLAR--KLPDNFNEAKFI---TFS 787

  Fly   843 VVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARNDIIDPVIHS 904
            :||..|: :..:...||.  ::|:| :.|.| ||.||...|..:|.||.:.|     |..|
Zfish   788 MVIFCAVWITFIPAYISSPGKLTVA-VEIFA-ILASTFGLLFCIFTPKCYII-----IFKP---- 841

  Fly   905 MGLKMECNTRRFVV 918
                 |.|||:.::
Zfish   842 -----EQNTRKHIM 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	97/570 (17%)
		ANF_receptor	174..568	CDD:279440	90/517 (17%)
		7tm_3	633..889	CDD:278433	61/266 (23%)
olfch1	NP_001103760.1	Periplasmic_Binding_Protein_Type_1	34..508	CDD:299141	85/479 (18%)
		ANF_receptor	75..474	CDD:279440	69/404 (17%)
		NCD3G	517..568	CDD:284890	15/96 (16%)
		7tm_3	604..836	CDD:278433	61/267 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910