Protein Alignment GABA-B-R3 and olfcg5

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001103413.1
• Gene: olfcg5 / 100004890
• ZFINID: ZDB-GENE-060503-913
• Length: 833
• Species: Danio rerio
• Alignment Length: 889
• Identity: 188/889 - (21%)
• Similarity: 323/889 - (36%)
• Gaps: 295/889 - (33%)

  Fly   181 AVEHINR-KRLLP----GY---------------TLELVTNDTQCDPGVGVDRFF--HAIYTQPS 223
            |:|.||| :.|||    ||               |:.|: ||.:...|...:..:  |||
Zfish    85 AIEEINRSESLLPNVSIGYKIYDSCGSRLSSISATMSLM-NDQEFPKGNICNGQYPIHAI----- 143

  Fly   224 TRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAF 288
                  :|...|..|..|::....:.|..:|..:|...||:||::|.|:||:|.|...:.|....
Zfish   144 ------IGETESSATVILSRTTGPFKIPVISHSATCECLSNRRDYPSFFRTIASDYHQSRALAYI 202

  Fly   289 IRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATDFKEQLLLLRET----DTR 349
            ::.|||..|...:.:.:..:..:...:...:...|....::.|..|: .|:|..:.||    .|:
Zfish   203 VKYFGWSWVGAVNSDNDYGNNGMAIFLKTAQEEGICVEYSVKFYRTE-PEKLQKVVETMKRSTTK 266

  Fly   350 IIIGSFS--------QELAPQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAV 406
            |||...|        :||:.|.:.   ..::.|.: ||...:|:..|
Zfish   267 IIIAFLSRVEMVNLLEELSIQNIS---GFQVIGVE-AWTTAKSLITP------------------ 309

  Fly   407 ENLIVVSTHNS--IVGNNVSYS-------GLNNHMF--------------NSQLRKQSAQFHGQD 448
                     ||  |:|.::.::       |..:::.              :|||:...
Zfish   310 ---------NSFHILGGSLGFAVRKIDTEGFLDYVIKSFWDSAFPCLIVNSSQLKVNC------- 358

  Fly   449 GFGSGYGSRISIAATQSDSRRRRRRGVGGTSGGHLFPEAISQYAPQTYDAVWAIALALRAAEEHW 513
               |.|...:.:.....|                 .||  .:||...|.||:|:|.:|     |.
Zfish   359 ---SSYKDLLVLKNDNED-----------------VPE--QRYASNVYKAVYAVAHSL-----HS 396

  Fly   514 RRNEEQSKLDGFDYTRSDMAWEFLQQMGKLHFLGVSGPVSFSGPDRV------GTTAFYQI---- 568
            ..|.::.|  |.....:...::.::.:.|::|     .:.|.  |||      .|.|.|::
Zfish   397 LLNCKEKK--GCQKNLTIQPYQMVEALKKVNF-----TIKFG--DRVWFDSTGATIAQYEVVNWQ 452

  Fly   569 --QRGLLE--PVALYYPATDALDFR-------------------------CP--------RCRPV 596
              ..||::  ||. ||.|:...|.|                         ||        :.|||
Zfish   453 QDSDGLIQFKPVG-YYDASLPPDKRFVVKTENIIWAGGKLKKPKSVCSESCPPGTRKAAQKGRPV 516

  Fly   597 ------------------KWHSGQVPIA--------KRVFKLRVATIAPLAFYTIA-------TL 628
                              ..:..|.|:.        |.|||    ::..|:|..:.       :|
Zfish   517 CCYDCIPCAEGEISNETDSVNCKQCPLEYWSNTEKNKCVFK----SVEFLSFTEVMGVVLVFFSL 577

  Fly   629 SSVGIALAIAFLAFNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFAT 693
            ..||:.:.:|.|.:|.  :....:|.::.:||.:    .:|......|..|.....|:...
Zfish   578 FGVGLTMLVAILFYNK--KDTPIVKANNSELSFL----LLFSLTLCFLCSLTFIGRPTEWS---- 632

  Fly   694 VCTARVYLLSAGFSLAFGSMFAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLV 756
             |..|.......|.|....:..||..|...|..|  ||... |....:|..|.|....|:..::.
Zfish   633 -CMLRHTTFGITFVLCISCVLGKTIVVLMAFKATLPGSNIM-KWFGPVQQRLSVLAFTLIQVIIC 695

  Fly   757 TLWVVTDP------MERHLHNLTLEIS--ATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLV 813
            .||::..|      |:.:...:.||.|  ||           :|.|       :||: |.|||.:
Zfish   696 VLWLIISPPFPYKNMKYYKEKIILECSLGAT-----------ICFS-------AVLF-YIGLLAI 741

  Fly   814 VGVYMAWETRHVKIP-ALNDSQYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILT 874
            :...:|:..|  |:| ..|::::|   .:|::|..|: :..:...:|.  :.|:| :.|.| ||.
Zfish   742 LCFILAFLAR--KLPDNFNEAKFI---TFSMLIFCAVWITFIPAYVSSPGKFTVA-VEIFA-ILA 799

  Fly   875 STTATLCLLFIPKLHDIWARNDIIDPVIHSMGLKMECNTRRFVV 918
            |:...|..:|:||.:.|..:|              |.||::.::
Zfish   800 SSFGLLFCIFVPKCYIILFKN--------------EQNTKQHIM 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	108/540 (20%)
		7tmC_GABA-B-like	621..892	CDD:320175	68/291 (23%)
		TM helix 1	621..645	CDD:320175	7/30 (23%)
		TM helix 2	657..678	CDD:320175	4/20 (20%)
		TM helix 3	696..720	CDD:320175	5/23 (22%)
		TM helix 4	741..761	CDD:320175	5/19 (26%)
		TM helix 5	797..823	CDD:320175	7/25 (28%)
		TM helix 6	832..855	CDD:320175	4/23 (17%)
		TM helix 7	862..887	CDD:320175	9/24 (38%)
olfcg5	NP_001103413.1	Periplasmic_Binding_Protein_type1	42..486	CDD:471960	103/488 (21%)
		NCD3G	494..547	CDD:462210	7/52 (13%)
		7tmC_V2R_pheromone	568..818	CDD:320410	68/287 (24%)
		TM helix 1	568..592	CDD:320410	5/23 (22%)
		TM helix 2	604..625	CDD:320410	5/24 (21%)
		TM helix 3	634..658	CDD:320410	5/23 (22%)
		TM helix 4	682..698	CDD:320410	3/15 (20%)
		TM helix 5	725..751	CDD:320410	11/44 (25%)
		TM helix 6	759..782	CDD:320410	4/25 (16%)
		TM helix 7	787..812	CDD:320410	9/26 (35%)