DRSC/TRiP Functional Genomics Resources

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Protein Alignment GABA-B-R3 and olfcg3

DIOPT Version :10

Sequence 1:NP_523447.2 Gene:GABA-B-R3 / 33248 FlyBaseID:FBgn0031275 Length:1305 Species:Drosophila melanogaster
Sequence 2:NP_001103412.1 Gene:olfcg3 / 100004682 ZFINID:ZDB-GENE-060503-159 Length:837 Species:Danio rerio


Alignment Length:872 Identity:166/872 - (19%)
Similarity:306/872 - (35%) Gaps:260/872 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 AVEHINRK-RLLPGYTLELVTNDTQC-----------------DPGVGVDRF-----FHAIYTQP 222
            |:|.|||. :|||..::.....|| |                 :.|.| :|.     .|||    
Zfish    85 AIEEINRSVQLLPNISIGYRIYDT-CGSRQSTMSAIMGLMNGQEFGAG-ERCNGRSPIHAI---- 143

  Fly   223 STRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIA 287
                   :|.:.|..|..|::....:.|..:|..::...||:::::|.|:||:|.|...:.|...
Zfish   144 -------IGESESSATVILSRTTGPFKIPVISHSASCECLSNKKDYPSFFRTMASDYHQSRALAY 201

  Fly   288 FIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATD---FKEQLLLLRETDTR 349
            .::..||..|...|.:.|..:..::..:...:...|.......|..|:   ..:.:.::::...:
Zfish   202 LVKDLGWSWVGAVSSDNEYGNYGMSIFLKIAQEVGICVEYYAKFYRTEAENLHKAVNMIKKGTAK 266

  Fly   350 IIIGSFSQE----LAPQILCEAYR-LRMFGADYAWILHESMGAPWWPDQRTACSNHELQLAVENL 409
            :|:...|..    |..|:..|... |:|.|.. :||..:|...|        .|.|.|:.::   
Zfish   267 VIVAFVSLPEMGILVDQLSIENITGLQMIGVK-SWITVKSFITP--------SSFHVLKGSL--- 319

  Fly   410 IVVSTHNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGF----GSGYGSRISIAATQSDSRRR 470
                   .|....:|..|...:..|...:|         ||    .....||.:::.::.:.   
Zfish   320 -------GIAVKKISVEGFAEYAINEFWKK---------GFPCLKSEVNSSRYALSCSRYED--- 365

  Fly   471 RRRGVGGTSGGHLF---------PEAISQYAPQTYDAVWAIALALRA---AEEHWRRNEEQSKLD 523
                        ||         ||  .:||...|.||:|:|.:|.:   .:||          :
Zfish   366 ------------LFVLKSISEDVPE--QRYASYVYKAVYAVAHSLHSLFNCKEH----------E 406

  Fly   524 GFDYTRSDMAWEFLQQMGKLHFLGVSGP-VSFSGP--------------DRVGTTAFYQI----- 568
            |.:...:....:.::.:.|:.|...:|. |.|...              |..|:|.|..:     
Zfish   407 GCEKDLTIQPQQVVEALKKVKFTIKTGDHVWFDSTGAAVAQYDVVNLQLDSYGSTLFKSVGYYDA 471

  Fly   569 ----------------------------------------QRGLLEPVALY----------YPAT 583
                                                    |:|  .||..|          ...|
Zfish   472 SLPPEQQFVLNTTNIIWAGGEQKVRSVCSESCPPGTRKATQKG--RPVCCYDCIQCADGEISNET 534

  Fly   584 DALDFRCPRCRPVKWHSGQVPIAKRVFKLRVATIAPLAF-------YTIATLSSVGIALAIAFLA 641
            |:.:  |.:|....|.:.:.  :|.|.|:    :..|:|       ..|.:|..|.:.:.:.||.
Zfish   535 DSNN--CKQCPEEYWPNTEK--SKCVLKI----VEFLSFTELMGIVLVIFSLFGVTLTVLVTFLF 591

  Fly   642 FNLHFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGF 706
            ::.  :....:|.::.:||.:    .:|......|..|.....|:...     |..|.......|
Zfish   592 YSK--KDTPIVKANNSELSFL----LLFSLTLCFLCSLTFIGRPTEWS-----CMLRHTTFGITF 645

  Fly   707 SLAFGSMFAKTYRVHRIFTRTGSVFKDKMLQ---DIQLILLVGGLLLVDALLVTLWVVTDPMERH 768
            .|....:..||..|...|..|  :..:.|::   .:|..|.|....|:..|:..:|         
Zfish   646 VLCISCILGKTIVVLMAFRAT--IPGNNMIKWFGPVQQRLSVLAFTLIQILICVVW--------- 699

  Fly   769 LHNLTLEISATDRSVVYQPQVEVCRSQHTQT---WLSVLYAYKGLLLVVGVYMAWETRHVKIP-A 829
               ||:......:::.|..:..:.......|   |  ::..|.|||.|:...:|:..|  .:| .
Zfish   700 ---LTISPPFPSKNIKYYKEKIILECSLGSTIGFW--IVLGYIGLLAVLCFILAFLAR--TLPDN 757

  Fly   830 LNDSQYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDI 891
            .|::::|   .:|::|..|: :..:...:|.  ::|:| :.|.| ||.|:...|..:|.||.:.|
Zfish   758 FNEAKFI---TFSILIFCAVWITFIPAYVSSPGKLTVA-VEIFA-ILASSFGLLFCIFAPKCYII 817

  Fly   892 WARNDIIDPVIHSMGLKMECNTRRFVV 918
            .              .|.|.||::.::
Zfish   818 L--------------FKPEQNTKQHIM 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GABA-B-R3NP_523447.2 PBP1_GABAb_receptor 156..600 CDD:380589 98/535 (18%)
7tmC_GABA-B-like 621..892 CDD:320175 59/287 (21%)
TM helix 1 621..645 CDD:320175 6/30 (20%)
TM helix 2 657..678 CDD:320175 4/20 (20%)
TM helix 3 696..720 CDD:320175 5/23 (22%)
TM helix 4 741..761 CDD:320175 5/19 (26%)
TM helix 5 797..823 CDD:320175 8/28 (29%)
TM helix 6 832..855 CDD:320175 4/23 (17%)
TM helix 7 862..887 CDD:320175 9/24 (38%)
olfcg3NP_001103412.1 Periplasmic_Binding_Protein_type1 42..488 CDD:471960 88/470 (19%)
NCD3G 496..548 CDD:462210 9/55 (16%)
7tmC_V2R_pheromone 569..819 CDD:320410 59/297 (20%)
TM helix 1 569..593 CDD:320410 5/23 (22%)
TM helix 2 605..626 CDD:320410 5/24 (21%)
TM helix 3 635..659 CDD:320410 5/23 (22%)
TM helix 4 683..699 CDD:320410 4/15 (27%)
TM helix 5 726..752 CDD:320410 8/27 (30%)
TM helix 6 760..783 CDD:320410 4/25 (16%)
TM helix 7 788..813 CDD:320410 9/26 (35%)

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