DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfcg2

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	NP_001103759.1	Gene:	olfcg2 / 100004628	ZFINID:	ZDB-GENE-060503-253	Length:	835	Species:	Danio rerio

Alignment Length:	868	Identity:	178/868 - (20%)
Similarity:	311/868 - (35%)	Gaps:	251/868 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINR-KRLLPGYTLELVTNDTQCDPGVGVDRFFHAIYT----QPSTR------MVMLLGSAC 234
            |:|.||: |.|||...:.....|| |...:.......|:.:    :|..|      :..:||.:.
Zfish    82 AIEEINKSKSLLPNIYIGYRIYDT-CGSRLSTMSATMAVLSGQEFRPRDRCNDQPPLHAILGESE 145

  Fly   235 SEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTT 299
            |..|..|::....:.:..:|..:|...||:|:::|.|:||:|.|...:.|....::.|||..|..
Zfish   146 SSATVILSRTTGPFKVPVISPSATCECLSNRKDYPSFFRTIASDYHQSRALAYIVKHFGWTWVGA 210

  Fly   300 FSQNEEV--HSLAVNNLVTELEAANISCAATITFAATD---FKEQLLLLRETDTRIIIGSFSQEL 359
            .|.:.:.  :.:|:...:.:.|  .|....::.|..|:   .|:.:..:::...::|:
Zfish   211 VSSDNDYGNNGMAIFQKIAQEE--GICVEYSVKFYRTESDKLKKVVNEIKKGTAKVIV------- 266

  Fly   360 APQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHEL--QLAVENLI---------VVS 413
                              |::....||.              |  ||:::|:.         .::
Zfish   267 ------------------AFVSFVEMGL--------------LIDQLSIQNITGFQLIGVESWIT 299

  Fly   414 THNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGF-----------------GSGYGSRISIA 461
            |.|....|  |:|.|...: ...:||.:.     :||                 ..|..|:.||:
Zfish   300 TKNYFTPN--SFSSLRGSL-GFAVRKINI-----EGFIDYVIKAFWDTAFPCTKTEGNSSQYSIS 356

  Fly   462 ATQSDSRRRRRRGVGGTSGGHLFPEAI--SQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDG 524
            .|:|:.....:.          :.|.:  .:||...|.||:|:|.:|.:.    ...|.|...|.
Zfish   357 CTRSEDLLELKN----------YTEDVLEQRYASNVYKAVYAVAHSLHSL----LGCENQGLCDK 407

  Fly   525 FDYTRSDMAWEFLQ------QMGK-----------LHFLGVSGPVSFSGPDRVGTTAFYQI---- 568
            ....|.....|.||      |||.           .|:..|:....|.|..:..|..:|..
Zfish   408 NKPIRPQQMVEALQKVNFTIQMGDQVWFDSTGGTVAHYEVVNWQQDFDGSFQFKTVGYYDASLPP 472

  Fly   569 -QRGLL----------------------------------EPVALY--YPA--------TDALDF 588
             ||.:|                                  .||..|  .|.        ||:::
Zfish   473 QQRLMLNTKNIIWAGGQQKKPNSVCSESCPPGTRKAAQKGRPVCCYDCIPCAEGEISNETDSIN- 536

  Fly   589 RCPRCRPVKWHSGQVP--IAKRVFKLRVATIAP--LAFYTIATLSSVGIALAIAFLAFNLHFRK- 648
             |.:|....|.:.:..  :.|.|..|....|..  |.|:::     .|:.|..  |...|.:||
Zfish   537 -CKQCLEEYWSNAEKNKCVLKAVEFLSFTEIMGIILVFFSL-----FGVVLTT--LVTVLFYRKK 593

  Fly   649 -LKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGS 712
             ...:|.::.:||.:    .:|..:...|..|.....|:...     |..|..:....|.|....
Zfish   594 DTPIVKANNSELSFL----LLFSLSLCFLCSLTFIGRPTEWS-----CMLRHTVFGITFVLCISC 649

  Fly   713 MFAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERHL 769
            :..||..|...|..|  ||... |....:|..|.|....|:..::..:|:...|      ||.:.
Zfish   650 VLGKTIVVLMAFKATLPGSNVM-KWFGPVQQRLSVLAFTLIQIIICVVWITLSPPFPYKNMEYYK 713

  Fly   770 HNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDS 833
            ..:.:|                |....|..:.:|| .|..||.|:...:|:..|  |:| ..|::
Zfish   714 EKIIIE----------------CNLGSTLGFWAVL-GYISLLSVLCFVLAFLAR--KLPDNFNEA 759

  Fly   834 QYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARN 895
            ::|   .:|::|..|: :..:...:|.  ::|:| :.|.| ||:|:...|..:|.||.:.|.
Zfish   760 KFI---TFSMLIFCAVWITFIPAYVSSPGKLTVA-VEIFA-ILSSSFGLLFCIFAPKCYIIL--- 816

  Fly   896 DIIDPVIHSMGLKMECNTRRFVV 918
                       ||.|.||::.::
Zfish   817 -----------LKPEQNTKQHMM 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	100/520 (19%)
		ANF_receptor	174..568	CDD:279440	91/449 (20%)
		7tm_3	633..889	CDD:278433	62/269 (23%)
olfcg2	NP_001103759.1	PBP1_GPCR_family_C_like	38..480	CDD:153138	94/461 (20%)
		ANF_receptor	74..451	CDD:279440	87/432 (20%)
		NCD3G	495..545	CDD:284890	8/51 (16%)
		7tm_3	589..814	CDD:278433	59/258 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910