Protein Alignment GABA-B-R3 and olfcg2

DIOPT Version :10

• Sequence 1: NP_523447.2
• Gene: GABA-B-R3 / 33248
• FlyBaseID: FBgn0031275
• Length: 1305
• Species: Drosophila melanogaster
• Sequence 2: NP_001103759.1
• Gene: olfcg2 / 100004628
• ZFINID: ZDB-GENE-060503-253
• Length: 835
• Species: Danio rerio
• Alignment Length: 868
• Identity: 178/868 - (20%)
• Similarity: 311/868 - (35%)
• Gaps: 251/868 - (28%)

  Fly   181 AVEHINR-KRLLPGYTLELVTNDTQCDPGVGVDRFFHAIYT----QPSTR------MVMLLGSAC 234
            |:|.||: |.|||...:.....|| |...:.......|:.:    :|..|      :..:||.:.
Zfish    82 AIEEINKSKSLLPNIYIGYRIYDT-CGSRLSTMSATMAVLSGQEFRPRDRCNDQPPLHAILGESE 145

  Fly   235 SEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPARIAFIRKFGWGTVTT 299
            |..|..|::....:.:..:|..:|...||:|:::|.|:||:|.|...:.|....::.|||..|..
Zfish   146 SSATVILSRTTGPFKVPVISPSATCECLSNRKDYPSFFRTIASDYHQSRALAYIVKHFGWTWVGA 210

  Fly   300 FSQNEEV--HSLAVNNLVTELEAANISCAATITFAATD---FKEQLLLLRETDTRIIIGSFSQEL 359
            .|.:.:.  :.:|:...:.:.|  .|....::.|..|:   .|:.:..:::...::|:
Zfish   211 VSSDNDYGNNGMAIFQKIAQEE--GICVEYSVKFYRTESDKLKKVVNEIKKGTAKVIV------- 266

  Fly   360 APQILCEAYRLRMFGADYAWILHESMGAPWWPDQRTACSNHEL--QLAVENLI---------VVS 413
                              |::....||.              |  ||:::|:.         .::
Zfish   267 ------------------AFVSFVEMGL--------------LIDQLSIQNITGFQLIGVESWIT 299

  Fly   414 THNSIVGNNVSYSGLNNHMFNSQLRKQSAQFHGQDGF-----------------GSGYGSRISIA 461
            |.|....|  |:|.|...: ...:||.:.     :||                 ..|..|:.||:
Zfish   300 TKNYFTPN--SFSSLRGSL-GFAVRKINI-----EGFIDYVIKAFWDTAFPCTKTEGNSSQYSIS 356

  Fly   462 ATQSDSRRRRRRGVGGTSGGHLFPEAI--SQYAPQTYDAVWAIALALRAAEEHWRRNEEQSKLDG 524
            .|:|:.....:.          :.|.:  .:||...|.||:|:|.:|.:.    ...|.|...|.
Zfish   357 CTRSEDLLELKN----------YTEDVLEQRYASNVYKAVYAVAHSLHSL----LGCENQGLCDK 407

  Fly   525 FDYTRSDMAWEFLQ------QMGK-----------LHFLGVSGPVSFSGPDRVGTTAFYQI---- 568
            ....|.....|.||      |||.           .|:..|:....|.|..:..|..:|..
Zfish   408 NKPIRPQQMVEALQKVNFTIQMGDQVWFDSTGGTVAHYEVVNWQQDFDGSFQFKTVGYYDASLPP 472

  Fly   569 -QRGLL----------------------------------EPVALY--YPA--------TDALDF 588
             ||.:|                                  .||..|  .|.        ||:::
Zfish   473 QQRLMLNTKNIIWAGGQQKKPNSVCSESCPPGTRKAAQKGRPVCCYDCIPCAEGEISNETDSIN- 536

  Fly   589 RCPRCRPVKWHSGQVP--IAKRVFKLRVATIAP--LAFYTIATLSSVGIALAIAFLAFNLHFRK- 648
             |.:|....|.:.:..  :.|.|..|....|..  |.|:::     .|:.|..  |...|.:||
Zfish   537 -CKQCLEEYWSNAEKNKCVLKAVEFLSFTEIMGIILVFFSL-----FGVVLTT--LVTVLFYRKK 593

  Fly   649 -LKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLAFGS 712
             ...:|.::.:||.:    .:|..:...|..|.....|:...     |..|..:....|.|....
Zfish   594 DTPIVKANNSELSFL----LLFSLSLCFLCSLTFIGRPTEWS-----CMLRHTVFGITFVLCISC 649

  Fly   713 MFAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------MERHL 769
            :..||..|...|..|  ||... |....:|..|.|....|:..::..:|:...|      ||.:.
Zfish   650 VLGKTIVVLMAFKATLPGSNVM-KWFGPVQQRLSVLAFTLIQIIICVVWITLSPPFPYKNMEYYK 713

  Fly   770 HNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-ALNDS 833
            ..:.:|                |....|..:.:|| .|..||.|:...:|:..|  |:| ..|::
Zfish   714 EKIIIE----------------CNLGSTLGFWAVL-GYISLLSVLCFVLAFLAR--KLPDNFNEA 759

  Fly   834 QYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIWARN 895
            ::|   .:|::|..|: :..:...:|.  ::|:| :.|.| ||:|:...|..:|.||.:.|.
Zfish   760 KFI---TFSMLIFCAVWITFIPAYVSSPGKLTVA-VEIFA-ILSSSFGLLFCIFAPKCYIIL--- 816

  Fly   896 DIIDPVIHSMGLKMECNTRRFVV 918
                       ||.|.||::.::
Zfish   817 -----------LKPEQNTKQHMM 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_523447.2	PBP1_GABAb_receptor	156..600	CDD:380589	103/530 (19%)
		7tmC_GABA-B-like	621..892	CDD:320175	64/284 (23%)
		TM helix 1	621..645	CDD:320175	4/23 (17%)
		TM helix 2	657..678	CDD:320175	4/20 (20%)
		TM helix 3	696..720	CDD:320175	5/23 (22%)
		TM helix 4	741..761	CDD:320175	4/19 (21%)
		TM helix 5	797..823	CDD:320175	8/25 (32%)
		TM helix 6	832..855	CDD:320175	4/23 (17%)
		TM helix 7	862..887	CDD:320175	9/24 (38%)
olfcg2	NP_001103759.1	Periplasmic_Binding_Protein_type1	39..485	CDD:471960	94/466 (20%)
		NCD3G	493..546	CDD:462210	8/54 (15%)
		7tmC_V2R_pheromone	567..817	CDD:320410	66/304 (22%)
		TM helix 1	567..591	CDD:320410	6/30 (20%)
		TM helix 2	603..624	CDD:320410	5/24 (21%)
		TM helix 3	633..657	CDD:320410	5/23 (22%)
		TM helix 4	681..697	CDD:320410	3/15 (20%)
		TM helix 5	724..750	CDD:320410	8/26 (31%)
		TM helix 6	758..781	CDD:320410	4/25 (16%)
		TM helix 7	786..811	CDD:320410	9/26 (35%)