DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GABA-B-R3 and olfcg9

DIOPT Version :9

Sequence 1:	NP_001245826.1	Gene:	GABA-B-R3 / 33248	FlyBaseID:	FBgn0031275	Length:	1305	Species:	Drosophila melanogaster
Sequence 2:	XP_021323509.1	Gene:	olfcg9 / 100003331	ZFINID:	ZDB-GENE-081029-6	Length:	847	Species:	Danio rerio

Alignment Length:	871	Identity:	162/871 - (18%)
Similarity:	299/871 - (34%)	Gaps:	257/871 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 AVEHINR-KRLLPGYTLELVTNDT------------------------QCDPGVGVDRFFHAIYT 220
            |:|.||| :.|||..:|.....||                        :|:....|    |||
Zfish    93 AIEEINRSESLLPKLSLGYKIYDTCSSKLSSMSATMALMNSFEFAGRDKCNGQTSV----HAI-- 151

  Fly   221 QPSTRMVMLLGSACSEVTESLAKVVPYWNIVQVSFGSTSPALSDRREFPYFYRTVAPDSSHNPAR 285
                     :|...|..|..|.:....:.|..:|..::...||.|:|:|.|:||::.|.....|.
Zfish   152 ---------IGETESSATVILTRTTGPFKIPVISHAASCECLSSRKEYPSFFRTISSDYHQGRAL 207

  Fly   286 IAFIRKFGWGTVTTFSQNEEVHSLAVNNLVTELEAANISCAATITFAATD---FKEQLLLLRETD 347
            ...::..||..|...:.:.:..:..:...:.......|....:..|..|:   .|:.:..::::.
Zfish   208 AYIVKHLGWSWVGAVNSDNDYGNYGMAIFLNTAHKEGICVEYSEKFYRTEPEKLKKVVDTIKKST 272

  Fly   348 TRIIIGSFSQELAPQILCEAYR------LRMFGADYAW-------------ILHESMG------- 386
            .::|: :|...|..::|.|...      |::.|.: .|             :|..|:|
Zfish   273 AKVIV-AFISFLEMRLLVEQLSAENITGLQIVGVE-GWTTSKSLITPKTLNVLRGSLGFAMRKIY 335

  Fly   387 ---------APWW-------PDQRT------ACSNHELQLAVENLIVVSTHNSIVGNNVSYSGLN 429
                     .|:|       |:||.      .||.::..|.::|.|               ..:.
Zfish   336 IEGFAEYVLKPFWDTAFPCIPNQRNDSWVILNCSRYQDLLVLKNYI---------------EDVP 385

  Fly   430 NHMFNSQLRKQSAQFHGQDGFGSGYGSRISIA-ATQSDSRRRRRRGVGGTSGGHLFPEAISQYAP 493
            .|.|:..:                |.:..::| |..|..:.:.:.|..        .:.::| ..
Zfish   386 EHRFSINV----------------YNAVYAVAHALHSLFKCKEQEGCE--------KDLLTQ-PQ 425

  Fly   494 QTYDAVWAIALALRAAEEHWRRNEEQSKLDGFDYTRSDMA------WEFLQQMGKLHFLGVSGPV 552
            |..||:..:...::..:..|           ||.|.:.:|      |: ....|.::|..|....
Zfish   426 QVVDALKKVNFTVKMGDRVW-----------FDSTGATLAQYEVVNWQ-QNSDGSVNFKKVGYYD 478

  Fly   553 SFSGPDRVGTTAFYQI--------------------------QRGLLEPVALY--YP------AT 583
            :...||:.......:|                          |:|  .|:..|  .|      :.
Zfish   479 ASLPPDQRFVLNIKEILWAGGNLKKPRSVCSESCPPGTRKAAQKG--RPICCYDCIPCADGEISN 541

  Fly   584 DALDFRCPRCRPVKWHSGQVP--IAKRVFKLRVATI--APLAFYTIATLSSVGIALAIAFLAFNL 644
            |.....|.:|:...|.:....  :.|.|..|....:  ..|.|:   :|...|:.:.:|.|.::.
Zfish   542 DTDSNNCKQCQGEYWSNADKNKCVQKSVEFLSFTEVMGIVLVFF---SLFGAGLTVLVAILFYSK 603

  Fly   645 HFRKLKAIKLSSPKLSNITAVGCIFVYATVILLGLDHSTLPSAEDSFATVCTARVYLLSAGFSLA 709
              :....:|.::.:||.:    .:|......|..|.....|:...     |..|.......|.|.
Zfish   604 --KDTPIVKANNSELSFL----LLFSLTLCFLCSLTFIGQPTQWS-----CMLRHTAFGITFVLC 657

  Fly   710 FGSMFAKTYRVHRIFTRT--GSVFKDKMLQDIQLILLVGGLLLVDALLVTLWVVTDP------ME 766
            ...:..||..|...|..|  ||... |....:|..|.|.....:..|:..||:...|      |:
Zfish   658 ISCVLGKTLLVLMAFKATLPGSNIM-KWFGPVQQRLSVLAFTFIQVLICVLWLSISPPFPHKNMK 721

  Fly   767 RHLHNLTLEISATDRSVVYQPQVEVCRSQHTQTWLSVLYAYKGLLLVVGVYMAWETRHVKIP-AL 830
            .:...:.||                |....|..:.::| .|.|||..:...:|:..|  .:| ..
Zfish   722 YYEEKIILE----------------CSLGSTIGFWAIL-GYIGLLAALCFILAFLAR--TLPDNF 767

  Fly   831 NDSQYIGVSVYSVVITSAI-VVVLANLISE--RVTLAFITITALILTSTTATLCLLFIPKLHDIW 892
            |::::|   .:|::|..|: :..:...:|.  :.|:| :.|.|::.:|.:..|| :|.||.:.|.
Zfish   768 NEAKFI---TFSMLIFCAVWITFIPAYVSSPGKFTVA-VEIFAILSSSISLLLC-IFAPKCYIIL 827

  Fly   893 ARNDIIDPVIHSMGLKMECNTRRFVV 918
                          ||.|.||:::::
Zfish   828 --------------LKPEQNTKQYML 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GABA-B-R3	NP_001245826.1	PBP1_GABAb_receptor	157..590	CDD:107361	89/525 (17%)
		ANF_receptor	174..568	CDD:279440	82/469 (17%)
		7tm_3	633..889	CDD:278433	57/267 (21%)
olfcg9	XP_021323509.1	Periplasmic_Binding_Protein_Type_1	44..496	CDD:324556	83/471 (18%)
		NCD3G	505..557	CDD:311495	8/53 (15%)
		7tmC_V2R_pheromone	578..828	CDD:320410	62/302 (21%)
		TM helix 1	578..602	CDD:320410	6/26 (23%)
		TM helix 2	614..635	CDD:320410	5/24 (21%)
		TM helix 3	644..668	CDD:320410	5/23 (22%)
		TM helix 4	692..708	CDD:320410	3/15 (20%)
		TM helix 5	735..761	CDD:320410	7/26 (27%)
		TM helix 6	769..792	CDD:320410	4/25 (16%)
		TM helix 7	797..822	CDD:320410	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910