Protein Alignment Eaat2 and SLC1A6

DIOPT Version :9

• Sequence 1: NP_001162844.1
• Gene: Eaat2 / 33247
• FlyBaseID: FBgn0026438
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001371598.1
• Gene: SLC1A6 / 6511
• HGNCID: 10944
• Length: 564
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 212/526 - (40%)
• Similarity: 317/526 - (60%)
• Gaps: 45/526 - (8%)

  Fly    44 RWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAG 108
            |:|..|..:|:|:|.|::||.|..:|||..|....|...|:||||.||:|::::|||::|||:.|
Human    51 RFLRRNAFILLTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTG 115

  Fly   109 SASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPG---NPDLHNADDRSTDRRAVNLLD 170
            .|||:.|..|::.:|..||:..|:.....:||.:|.:||||   ...||    |......:...|
Human   116 MASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLH----REGRIETIPTAD 176

  Fly   171 SLLDLGRNVFPDNLFQASIQQAHTVY---------------------LPKPSILHVFNETM---N 211
            :.:||.||:||.||.:|..:|..|.|                     :|.|  ..|.|.|.   |
Human   177 AFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPP--FSVENGTSFLEN 239

  Fly   212 DTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAI 276
            .|.|.|:..:.||.:.|..|.     ...:|.|.||:|.|.:.||..:|.:..||:|:.|||.::
Human   240 VTRALGTLQEMLSFEETVPVP-----GSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSL 299

  Fly   277 FEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFV 341
            .|.||::|..::|..||||..:||||||.:.|:.::..||..:.:||.:|:|::..:|:..|||:
Human   300 NEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFL 364

  Fly   342 VVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTAL 406
            |..||||.|..|::||::||..|:|::|.|||||||:.|.|.||.||||||||:|..:|||||||
Human   365 VTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTAL 429

  Fly   407 YIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLF 471
            |.|:|:|||||::...|..|::.|:.:|:||||:.:|.:|.|.||.:::|||::..|.:|:||:.
Human   430 YEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLII 494

  Fly   472 AVDWFVDRIRTTNNMLGDCYTAAVVEELSRKEL------MALDAASVNYQDMPAGTPNGHGHGHG 530
            |||||:||:||..|:|||...|||:|.||::||      :.|.:....|:.:.| ...|...|.|
Human   495 AVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMA-QEKGASRGRG 558

  Fly   531 HHDGGL 536
            .::..:
Human   559 GNESAM 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	197/471 (42%)
SLC1A6	NP_001371598.1	SDF	58..522	CDD:395299	199/474 (42%)
		Aspartate binding. /evidence=ECO:0000250|UniProtKB:P43003	388..390		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250|UniProtKB:P43003	468..472		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm40767
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.730