DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat2 and SLC1A4

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_003029.2	Gene:	SLC1A4 / 6509	HGNCID:	10942	Length:	532	Species:	Homo sapiens

Alignment Length:	511	Identity:	181/511 - (35%)
Similarity:	291/511 - (56%)	Gaps:	42/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MEKSGKFSDYL-FAKMGPPTSTELPPKTTECSDAPVELTGYRR----WLSENLMLLVTLSGVLLG 62
            ||||.:.:.|| .|:.||...          ..||....|..|    :|....::|:|:||||.|
Human     1 MEKSNETNGYLDSAQAGPAAG----------PGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAG 55

  Fly    63 VILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVY 127
            ..||.:||.|:|....:..:::|||:.:|:|:::|||||:.||::|:|||:|...|::....:.|
Human    56 AGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY 120

  Fly   128 FASTSFFNAALGIALVLLIHPGN--PDLHNAD----DRSTDRRAVNLLDSLLDLGRNVFPDNLFQ 186
            |..|:...:||.:||..:|.||:  ..|.::|    |..........:||.|||.||:||.||..
Human   121 FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVV 185

  Fly   187 ASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFF 251
            |:.:...|.|           :.:....:||:...       |.:.:..:|:   |.|.||:|.|
Human   186 AAFRTYATDY-----------KVVTQNSSSGNVTH-------EKIPIGTEIE---GMNILGLVLF 229

  Fly   252 CLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQL 316
            .||.|..|..:|.:|:.::.||.::.|..|.:|:.:||..||||..::..||:.:.|:.::::.|
Human   230 ALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSL 294

  Fly   317 MWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEK 381
            ..:|....:|..|:..:|:..||||..|:|||:|..||:....|||||.|::|.||...:|:.|.
Human   295 GKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEEN 359

  Fly   382 LKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVP 446
            ..||.||:||:||||..:||||.|::..||::||||::.:.|..|::.|:|:|:||:|:.:|.||
Human   360 NGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVP 424

  Fly   447 SAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRK 502
            :..::.:.::|.||..|..|:.|:.||||.|||..|..|:.||...|.::..|::|
Human   425 AGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	165/450 (37%)
SLC1A4	NP_003029.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		9/33 (27%)
		SDF	72..477	CDD:306807	152/425 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830