DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and SLC1A3

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_004163.3	Gene:	SLC1A3 / 6507	HGNCID:	10941	Length:	542	Species:	Homo sapiens

Alignment Length:	473	Identity:	203/473 - (42%)
Similarity:	313/473 - (66%)	Gaps:	5/473 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIA 107
            :.:|..|..:|:|::.|::|.|||.:|||..:....:...|:||||.||:|::::|||:||||:.
Human    42 KSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVT 106

  Fly   108 GSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSL 172
            |.|:|::|.:||:.:|.:||:.:|:.....:||.:|::||||.....|........| |...|:.
Human   107 GMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVR-VTAADAF 170

  Fly   173 LDLGRNVFPDNLFQASIQQAHTVYLPKPSILHV-FNETMNDTLASG-SEAQRLSEDLTEDVVLVR 235
            |||.||:||.||.:|..:|..|.|..:...:.: .|||:...:.:. |||......:||::|.|.
Human   171 LDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVP 235

  Fly   236 DIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIA 300
            ...  :|.|.||:|.|.:.||..:|.:.::||.:.:||.::.|.||::|..:||..||||..:||
Human   236 GSV--NGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIA 298

  Fly   301 GKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATA 365
            |||:.:.|:|::..||..:.|||.:|:.|:..:|:..:||:|.|:||:.|..||:||::||..|:
Human   299 GKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTS 363

  Fly   366 STAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLT 430
            |::|.|||||:|:.|...||.|:||||||:|..|||||||||.|:|:|||||::...|.||:::|
Human   364 SSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIIT 428

  Fly   431 VLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAV 495
            :.:|:||||:.:|.:|.|.||.:::|||::..|..|:||:.|||||:||:|||.|:|||...|.:
Human   429 ISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGI 493

  Fly   496 VEELSRKELMALDAASVN 513
            ||.|||.||...|....|
Human   494 VEHLSRHELKNRDVEMGN 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	192/446 (43%)
SLC1A3	NP_004163.3	SDF	50..497	CDD:306807	194/449 (43%)
		Aspartate binding. /evidence=ECO:0000269\|PubMed:28424515, ECO:0007744\|PDB:5LM4	363..365		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000269\|PubMed:28424515, ECO:0007744\|PDB:5LM4	443..447		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm40767
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.730