DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat2 and slc1a2a

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001177234.1	Gene:	slc1a2a / 560802	ZFINID:	ZDB-GENE-100422-11	Length:	548	Species:	Danio rerio

Alignment Length:	517	Identity:	225/517 - (43%)
Similarity:	335/517 - (64%)	Gaps:	23/517 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LSENLMLLVTLSGVLLGVILGLSLRPLN-LHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGS 109
            |.:||:|.:|:.||:.|.:.|:.||..: |..|.||:|::||::.||:||::||||:|||||.|.
Zfish    32 LMKNLLLTLTVLGVITGSVAGILLRYASPLPADVIMVIAFPGDILMRMLKMVILPLIISSLITGL 96

  Fly   110 ASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDL--HNADDRSTDRRAVNLLDSL 172
            |.|:||.:|::..|.::|:.||:...|.||:.||||||||||.|  :..:.:..|.  |:.||:.
Zfish    97 AGLDAKSSGRLGTRAMIYYMSTTVIAAVLGVILVLLIHPGNPKLKANLGEGKKNDE--VSSLDAF 159

  Fly   173 LDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDV---VLV 234
            .||.||:||:||.||..||..||             |....:|......|...:.|:..   |:.
Zfish   160 FDLIRNLFPENLVQACFQQIQTV-------------TTKVEIAPPPPPTRFGRNATKGAAKYVIK 211

  Fly   235 RDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVI 299
            :.:|::||.|.|||:.|.:.||..:|.:|:|.:::||||..:.|::|::|..:||.:|:||:.:|
Zfish   212 KSLQFKSGMNVLGIIGFFVAFGICMGKMGEKAKLMVDFFNTLNEIVMRLVGMIMWYSPIGIACLI 276

  Fly   300 AGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFAT 364
            .|||:|:.||.:|..||..::|||.:|:.|:..:.:..||||:||:|||||:.||.||.:||..|
Zfish   277 CGKIISINDLEMVAKQLGMYMVTVIVGLIIHGGIFLPLIYFVIVRKNPFKFFMGLFQAWVTALGT 341

  Fly   365 ASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELL 429
            ||:|..||:||||:.|.|.:|.|:||||||:|..|||||||||.|||:||||||:|:.|..|:::
Zfish   342 ASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGIELDPGQIV 406

  Fly   430 TVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAA 494
            ||.||:|.||:.:||:|||.||.:|::|||:..|.||::||.||||.:||.||:.|::||.|.|.
Zfish   407 TVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTQDISLLVAVDWLLDRFRTSVNVIGDSYGAG 471

  Fly   495 VVEELSRKELMALDAASVNYQDMPAGTPNGHGHGHGHHDGGLLEGQTELETSSKCVMTMTDS 556
            :|..||:.||...||..:...|........:...:.:|  |:.....:......|.:|:..:
Zfish   472 IVYHLSKDELDMFDAQQIRPDDFEMAKTQSYYENNSNH--GVYHNSCQPIQIDDCKVTLASN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	210/450 (47%)
slc1a2a	NP_001177234.1	SDF	46..476	CDD:278787	207/444 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	411	1.000	Domainoid score	I653
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1691
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm25669
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980