DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat2 and Slc1a4

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_061349.3	Gene:	Slc1a4 / 55963	MGIID:	2135601	Length:	532	Species:	Mus musculus

Alignment Length:	514	Identity:	179/514 - (34%)
Similarity:	292/514 - (56%)	Gaps:	48/514 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MEKSGKFSDYLFAKMGPPTSTELPPKTT-----ECSDAPVELTGYRRWLSENLMLLVTLSGVLLG 62
            |||||:.:.||......|.:....|:|.     .|:      :.:||    :.::|:|:||||:|
Mouse     1 MEKSGETNGYLDGTQAEPAAGPRTPETAMGKSQRCA------SFFRR----HALVLLTVSGVLVG 55

  Fly    63 VILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVY 127
            ..:|.:||.|.|....|..:::|||:.:|:|:::|||||:.||::|:|||:|...|::....:.|
Mouse    56 AGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSLGRLGGIAVAY 120

  Fly   128 FASTSFFNAALGIALVLLIHPG---------NPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDN 183
            |..|:...:||.:||..:|.||         :..|.|:......:..|   ||.|||.||:||.|
Mouse   121 FGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGPPPVSKETV---DSFLDLLRNLFPSN 182

  Fly   184 LFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGI 248
            |..|:...:.|.|           ..:....:||:..:       |.:.:|.|::   |.|.||:
Mouse   183 LVVAAFTTSATDY-----------TVVTHNTSSGNVTK-------EKIPVVTDVE---GMNILGL 226

  Fly   249 VFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVM 313
            |.|.||.|..|..:|.:|:.::.||.:..|..|.:|:.:||..|:||..:|..||:.:.|:.:::
Mouse   227 VLFALVLGVALKKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIVEMKDIVMLV 291

  Fly   314 SQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCM 378
            :.|..:|....:|..|:..:|:..:||...|:|||.|..||:....|||||.|::|.||...:|:
Mouse   292 TSLGKYIFASMLGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFATAFATCSSSATLPSMMKCI 356

  Fly   379 NEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSA 443
            .|...||.||:||:||||..:||||.|::..||::||||::.:.|..|::.|:|:|:||:|:.:|
Mouse   357 EENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAA 421

  Fly   444 SVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRK 502
            .||:..::.:.::|.||..|..|::|:.||||.|||..|..|:.||...|.::..|::|
Mouse   422 GVPAGGVLTIAIILEAIGLPTHDLSLILAVDWIVDRTTTVVNVEGDALGAGILNHLNQK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	164/453 (36%)
Slc1a4	NP_061349.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		10/27 (37%)
		SDF	44..477	CDD:278787	164/456 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830