DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat2 and slc1a3b

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001177232.1	Gene:	slc1a3b / 556181	ZFINID:	ZDB-GENE-090708-3	Length:	537	Species:	Danio rerio

Alignment Length:	488	Identity:	204/488 - (41%)
Similarity:	320/488 - (65%)	Gaps:	25/488 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGS 109
            :|..|..:|.|:..|:.|:.||.:||...:....:...|:||||.||:|::::|||::||||.|.
Zfish    44 FLRRNAFVLFTIGAVVFGITLGFALRSYKMSYREVKYFSFPGELLMRMLQMLVLPLLVSSLITGM 108

  Fly   110 ASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLL---DS 171
            |:|:::.:||:.:|.::|:.:|:|....:||.:||:||||.    .:.|..|.::.:..:   |:
Zfish   109 AALDSRASGKMGMRAVIYYMTTTFIAVFIGIIMVLIIHPGK----GSKDEFTKQQKIEQVSPADA 169

  Fly   172 LLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRD 236
            .|||.||:||.||.||..||..|.|..:  |:|| ...:||::.:.:.|.:  |...|:|:.:..
Zfish   170 FLDLIRNMFPPNLVQACTQQFKTQYGKR--IIHV-KMIVNDSIFNLTNATQ--EIAQEEVIPLSG 229

  Fly   237 IQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAG 301
            .  .:|.|.||:|.|.:.||..:|.:.::||.:.|||.::.|.||::|..:||..|:||..:|||
Zfish   230 T--TNGVNALGLVVFSMCFGLIIGNMKEQGQALRDFFDSLNEAIMRLVAIIMWYAPIGILFLIAG 292

  Fly   302 KILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATAS 366
            ||:.:.|:..:..||..:.|||.||:.|:..:::..:|||:.|:|||.|..||:||::||..|:|
Zfish   293 KIVEMDDITAMGGQLGMYTVTVIIGLMIHGIIILPTLYFVITRKNPFIFITGLLQALITALGTSS 357

  Fly   367 TAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTV 431
            ::|.|||||:|:.|..|||.|:||||||:|..|||||||||.|:|:|||||::.|.:.||:::|:
Zfish   358 SSATLPITFKCLEENNKVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNMEMNFGQIITI 422

  Fly   432 LLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVV 496
            .:|:||||:.:|.:|.|.||.:::|||::..|..|:||:.|||||:||:|||.|:|||...|.::
Zfish   423 SITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSIGAGII 487

  Fly   497 EELSRKELMALD---AASV--------NYQDMP 518
            |.||:.||...|   .:||        .||.:|
Zfish   488 EFLSKDELQGGDVELGSSVLEENELKKPYQKIP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	191/447 (43%)
slc1a3b	NP_001177232.1	SDF	50..487	CDD:278787	191/447 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm25669
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730