DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and slc1a4

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_005156843.1	Gene:	slc1a4 / 368885	ZFINID:	ZDB-GENE-030616-566	Length:	539	Species:	Danio rerio

Alignment Length:	507	Identity:	177/507 - (34%)
Similarity:	291/507 - (57%)	Gaps:	36/507 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKSGKFSDYLFAKMGPPTSTELPPKTTECSDAPVELTGYRRWLSENLMLLVTLSGVLLGVILGLS 68
            ||..:.:.:...|...|| ..:..:...|.|   :..|:   ...||::::|:||||:||.||:.
Zfish     3 EKKSEINGHAGHKCSLPT-VSIKSEKKSCKD---KCAGF---FKRNLLVIMTVSGVLVGVGLGMM 60

  Fly    69 LRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSF 133
            :|.:||....:...::|||:.:|:||::|||||:.|||:|:|||:.:..||:....:.||..|:.
Zfish    61 VRNMNLTRAQMTYFAFPGEMLLRMLKMIILPLVVCSLISGAASLDTRSLGKLGGIAVSYFLVTTL 125

  Fly   134 FNAALGIALVLLIHPG------NPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQA 192
            ..:::|:||..:|.||      |.:....:..|.::...   ||.|||.||:||.||..|:.:..
Zfish   126 IASSIGVALAFIIKPGVGAGALNTNNLGLEGVSNNKETA---DSFLDLARNLFPSNLVAAAFRSY 187

  Fly   193 HTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGT 257
            .|.|   .::| :.|.| |.||    ..|::......|           |.|.||:|.|.:|||.
Zfish   188 ATDY---KTVL-IGNGT-NGTL----NYQKVPFGTDTD-----------GMNILGLVLFAMVFGV 232

  Fly   258 FLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVT 322
            .|..:|.:|:.::.||.|..|..|.:|:.:||..|.||..::..||:.:.|:.|:::.|..:|..
Zfish   233 ALRKLGAEGEELIRFFNAFNEATMVLVSWIMWYVPFGIMFLVGSKIVEMEDVVLLVTSLGKYIFA 297

  Fly   323 VAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPR 387
            ..:|..|:..:::..|||...|.||:.|.:|||....|||||.|::|.||...:|:.|...||.|
Zfish   298 SILGHIIHGCIILPLIYFGFTRTNPYSFLSGLITPFTTAFATCSSSATLPTMMKCVEENNGVDKR 362

  Fly   388 ITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVL 452
            |:||:||||..:||||.|::..||::||||::.:.|..|::.|:|:|:||:|:.:|.:|:..::.
Zfish   363 ISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGIPAGGIIT 427

  Fly   453 LLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKEL 504
            :.::|.||..|..|::|:.||||.|||..|..|:.||...|.::..::.:|:
Zfish   428 IAIILEAIGLPTHDLSLMLAVDWIVDRTTTVVNVEGDALGAGILHHINEQEM 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	166/450 (37%)
slc1a4	XP_005156843.1	SDF	43..471	CDD:278787	166/450 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830