DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and Slc1a4

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_942058.1	Gene:	Slc1a4 / 305540	RGDID:	735146	Length:	529	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	176/511 - (34%)
Similarity:	291/511 - (56%)	Gaps:	45/511 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MEKSGKFSDYLFAKMGPPTSTELPPKTTECSDAPVE--LTGYRRWLSENLMLLVTLSGVLLGVIL 65
            ||::..:.|      |........|:|.|...:..:  .:.:||    |.::|:|:||||.|..:
  Rat     1 MEETNGYLD------GAQAQPAARPRTPETGTSKAQRCASFFRR----NALVLLTVSGVLAGAGM 55

  Fly    66 GLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFAS 130
            |.:||.|.|....|..:::|||:.:|:|:::|||||:.||::|:|||:|...|::....:.||..
  Rat    56 GAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASSLGRLGGIAVAYFGL 120

  Fly   131 TSFFNAALGIALVLLIHPG---------NPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQ 186
            |:...:||.:||..:|.||         :..|.|::.....:..|   ||.|||.||:||.||..
  Rat   121 TTLSASALAVALAFIIKPGVGAQTLHSSSLGLENSEPPPVSKETV---DSFLDLLRNLFPSNLVV 182

  Fly   187 ASIQQAHTVYLPKPSILHVFNETMNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFF 251
            |:...:.|.|   ..::|      |.:|.:.::         |.:.:|.|::   |.|.||:|.|
  Rat   183 AAFSTSATSY---TVVVH------NSSLGNVTK---------EKIPVVTDVK---GMNILGLVLF 226

  Fly   252 CLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQL 316
            .|:.|..|..:|.:|..::.||.:..|..|.:|:.:||..|:||..:|..||:.:.||.::::.|
  Rat   227 ALMLGVALKKLGPEGDELIRFFNSFNEATMVLVSWIMWYVPIGIMFLIGSKIVEMQDLIVLVTSL 291

  Fly   317 MWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEK 381
            ..:|....:|..|:..:|:..:||...|:|||.|..||:....|||||.|::|.||...:|:.|.
  Rat   292 GKYIFASILGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLTPFATAFATCSSSATLPSMMKCIEEN 356

  Fly   382 LKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVP 446
            ..||.||:||:||||..:||||.|::..||::||||::.:.|..|::.|:|:|:||:|:.:|.||
  Rat   357 NGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVDLNAGQIFTILVTATASSVGAAGVP 421

  Fly   447 SAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRK 502
            :..::.:.::|.||..|..|::|:.||||.|||..|..|:.||...|.::..|:::
  Rat   422 AGGVLTIAIILEAIGLPTNDLSLILAVDWIVDRTTTVVNVEGDALGAGILNHLNQR 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	165/453 (36%)
Slc1a4	NP_942058.1	SDF	41..474	CDD:278787	165/456 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830