DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and Slc1a7

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_666367.3	Gene:	Slc1a7 / 242607	MGIID:	2444087	Length:	559	Species:	Mus musculus

Alignment Length:	558	Identity:	202/558 - (36%)
Similarity:	310/558 - (55%)	Gaps:	53/558 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASLN 113
            |.:|::::..|::|.:||..||...|....|....:||||.||:||::|||||:|||::|.|||:
Mouse    17 NGLLILSVLSVIVGCLLGFFLRTQRLSPQEISYFQFPGELLMRMLKMLILPLVVSSLMSGLASLD 81

  Fly   114 AKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGRN 178
            ||.:.::.:.|:.|:..|:|....:||.:|.:||||........::| .:..::..|:||||.||
Mouse    82 AKTSSRLGILTVAYYLWTTFLAVVVGIIMVSIIHPGGAAQKETTEQS-GKPVMSSADALLDLVRN 145

  Fly   179 VFPDNLFQASIQQAHTVYLP-----------KPSILHVFNETMNDTLASGSEAQRLSEDLTEDVV 232
            :||.||.:|:.:|..|...|           .|..:.::. ...|   :||..|..:.|||..
Mouse   146 MFPANLVEATFKQYRTKTTPVIKSPRGAAEEAPRRIVIYG-VQED---NGSRVQNFALDLTPP-- 204

  Fly   233 LVRDIQYRS------GTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLT 291
              .:|.|:|      |.|.||||.|....|..||.:|..|..:|.|...:.|.:||:|....|..
Mouse   205 --PEIVYKSEPGTSDGMNVLGIVIFSATMGIMLGRMGDSGTPLVSFCQCLNESVMKIVAVAGWYF 267

  Fly   292 PVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQ 356
            |.||..:||||||.:.|...|..:|.::.|||..|:.::..:::..:||::.::||..|..|::|
Mouse   268 PFGIVFLIAGKILEMDDPKAVGKKLGFYAVTVVCGLVVHGLLILPLLYFLITKKNPIVFIRGVLQ 332

  Fly   357 AMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGM 421
            |:|.|.||:|::|.|||||:|:.|...:|.||.|||||:|..|||||||||.|||:|||||::..
Mouse   333 ALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNY 397

  Fly   422 VLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNM 486
            .|.||:::|:.:|:||||:.:|.:|.|.||.:::|||::..|..|:.|:.||||.:||.||..|:
Mouse   398 ELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDINLIIAVDWALDRFRTMINV 462

  Fly   487 LGDCYTAAVVEELSRKE---------LMALDAASVNYQDMPAGTPNG------------HGHGHG 530
            |||...|.::..:.||:         |:..:...|..|::.|...||            .|....
Mouse   463 LGDALAAGIMAHICRKDFAQDMGTEKLLPCETKPVTLQEIVAAQQNGCVKSVAEASELTLGPTCP 527

  Fly   531 HHDGGLLEGQTELETSSKCVMTMTDSVVVDISAVMNNV 568
            ||.      ..::|..........|...::||.:..||
Mouse   528 HHI------PVQVEQDEDPAAASLDHCTIEISELETNV 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	184/461 (40%)
Slc1a7	NP_666367.3	SDF	19..475	CDD:334043	184/464 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm42841
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.830