DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and Slc1a6

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	XP_006513485.3	Gene:	Slc1a6 / 20513	MGIID:	1096331	Length:	602	Species:	Mus musculus

Alignment Length:	534	Identity:	215/534 - (40%)
Similarity:	314/534 - (58%)	Gaps:	62/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIA 107
            ||:|..|..:|:|:|.|::||.|..:|||..|....|...|:||||.||:|::::|||::|||:.
Mouse    75 RRFLRRNAFILLTVSAVIIGVSLAFALRPYQLSYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVT 139

  Fly   108 GSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPG---NPDLHNADDRSTDRRAVNLL 169
            |.|||:.|..|::.:|..||:..|:.....:||.:|.:||||   ...||    |......|...
Mouse   140 GMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLH----REGRIETVPTA 200

  Fly   170 DSLLDLGRNVFPDNLFQASIQQAHTVY----------------------LPKPSILHVFNETM-- 210
            |:.:||.||:||.||.:|..:|..|.|                      .|..|   |.|||.
Mouse   201 DAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASMSPTSS---VENETSIL 262

  Fly   211 -NDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFA 274
             |.|.|.|:..:.:|.:.|..|.     ...:|.|.||:|.|.:.||..:|.:..||:|:.|||.
Mouse   263 ENVTRALGTLQEVISFEETVPVP-----GSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFD 322

  Fly   275 AIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIY 339
            ::.|.||::|..::|..||||..:||||||.:.|:.::..||..:.:||.:|:|::...|:..||
Mouse   323 SLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIY 387

  Fly   340 FVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGT 404
            |:|..||||.|..|::||::||..|:|::|.|||||||:.|.|.||.||||||||:|..:|||||
Mouse   388 FLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGT 452

  Fly   405 ALYIAVASIFIAQMSGMVLGFGELLTVLL-------------TSTAASMSSASVPSAALVLLLVV 456
            |||.|:|:|||||::...|..|::.|:.|             |:||||:.:|.:|.|.||.:::|
Mouse   453 ALYEALAAIFIAQVNNYELNLGQITTISLSSRIPDSLPVCSITATAASVGAAGIPQAGLVTMVIV 517

  Fly   457 LTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKEL------MALDAASVNYQ 515
            ||::..|.:|:||:.|||||:||:||..|:|||...|||:|.||::||      :.|.:....|:
Mouse   518 LTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYK 582

  Fly   516 DMPA---GTPNGHG 526
            .:.|   |...|.|
Mouse   583 SLMAQEKGASRGRG 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	199/485 (41%)
Slc1a6	XP_006513485.3	SDF	83..560	CDD:366058	201/488 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm42841
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730