DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and Slc1a2

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001070982.1	Gene:	Slc1a2 / 20511	MGIID:	101931	Length:	572	Species:	Mus musculus

Alignment Length:	544	Identity:	225/544 - (41%)
Similarity:	350/544 - (64%)	Gaps:	35/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LSENLMLLVTLSGVLLGVILGLSLRPLN-LHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGS 109
            |.:||:|.:|:.||:||.:.|..||..: :|.|.:|||::||::.||:||::||||:|||||.|.
Mouse    41 LGKNLLLSLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGL 105

  Fly   110 ASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLD 174
            :.|:||.:|::..|.:||:.||:...|.||:.|||.||||||.|............|:.||:.||
Mouse   106 SGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLD 170

  Fly   175 LGRNVFPDNLFQASIQQAHT----VYLPKPS--------ILHVFNETMNDTLASGSEAQRLSEDL 227
            |.||:||:||.||..||..|    |.:..||        ::.:.|||||:           :.:.
Mouse   171 LIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISMLNETMNE-----------APEE 224

  Fly   228 TEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTP 292
            |: :|:.:.::::.|.|.||::.|.:.||..:|.:|::.:::|:||..:.|::||:|..:||.:|
Mouse   225 TK-IVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSP 288

  Fly   293 VGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQA 357
            :||:.:|.|||:::.||.:|..||..:::||.:|:.|:..:.:..|||||.|:|||.|:||:.||
Mouse   289 LGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQA 353

  Fly   358 MLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMV 422
            .:||..|||:|..||:||||:.:.|.:|.|:||||||:|..|||||||||.|||:||||||:|::
Mouse   354 WITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVI 418

  Fly   423 LGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNML 487
            |..|:::||.||:|.||:.:||:|||.||.:|::|||:..|.:|::||.||||.:||:||:.|::
Mouse   419 LDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVV 483

  Fly   488 GDCYTAAVVEELSRKELMALDAASVNYQDMPAGTPNGHGHGHGHHDGGLLEGQTELETSSKCVMT 552
            ||.:.|.:|..||:.||..:|:.....:|:.............|.:          ..|::||..
Mouse   484 GDSFGAGIVYHLSKSELDTIDSQHRMQEDIEMTKTQSIYDDKNHRE----------SNSNQCVYA 538

  Fly   553 MTDSVVVDISAVMNNVNLQQEHCN 576
            ..:|||:|...|....|.:...|:
Mouse   539 AHNSVVIDECKVTLAANGKSADCS 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	204/457 (45%)
Slc1a2	NP_001070982.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		SDF	46..495	CDD:278787	205/460 (45%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	361..363		1/1 (100%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	441..445		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	409	1.000	Domainoid score	I696
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1717
Isobase	1	0.950	-	0	Normalized mean entropy	S3077
OMA	1	1.010	-	-		QHG62336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm42841
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	1	1.100	-	-	O	PTHR11958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2500
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810