DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and Slc1a1

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_033225.1	Gene:	Slc1a1 / 20510	MGIID:	105083	Length:	523	Species:	Mus musculus

Alignment Length:	506	Identity:	222/506 - (43%)
Similarity:	328/506 - (64%)	Gaps:	41/506 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 MGPPTSTELPPKTTECSDAPVELTGYRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIML 81
            ||.|||       :.|.        :||:|..:.:||.|::.|:||::||:.:|.   |.:...|
Mouse     1 MGKPTS-------SGCD--------WRRFLRNHWLLLSTVAAVVLGIVLGVVVRG---HSELSNL 47

  Fly    82 ----ISYPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIAL 142
                .::|||:.||:|||:||||::||:|.|.|:|::.::|||.||.:||:.||:.....|||.|
Mouse    48 DKFYFAFPGEILMRMLKLVILPLIVSSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVL 112

  Fly   143 VLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFN 207
            |:.|.||.....|..:|:.....|:.:|::|||.||:||:||.||..||..|   .:..:..|.:
Mouse   113 VVSIKPGVTQKVNDINRTGKTPEVSTMDAMLDLIRNMFPENLVQACFQQYKT---KREEVKPVGD 174

  Fly   208 ETMNDTLASGSEAQ-RLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVD 271
            ...|.|..|.:.|. .:||:.|::..:|.  .|..|.|.||::.||||||..:|.:|:|||::||
Mouse   175 PGGNATEVSVTTAMTTMSENKTKEYKIVG--LYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVD 237

  Fly   272 FFAAIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGD------LGLVMSQLMWFIVTVAIGVFIY 330
            ||.|:.:..||:|..:|...|:||..:|||||:.|.|      |||.|:       ||..|:.|:
Mouse   238 FFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMA-------TVLSGLAIH 295

  Fly   331 QFVVMQAIYFVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPI 395
            ..:|:..:||:|||:|||:|..|:.||:|||...:|::|.||:||||..||.:||.||||||||:
Mouse   296 SLIVLPLLYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPV 360

  Fly   396 GCNINMDGTALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAI 460
            |..|||||||||.|||::||||::|:.|..|:::|:.:|:||||:.:|.||.|.||.:::||:|:
Mouse   361 GATINMDGTALYEAVAAVFIAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSAV 425

  Fly   461 DAPVQDVTLLFAVDWFVDRIRTTNNMLGDCYTAAVVEELSRKELMALDAAS 511
            ..|.:||||:.||||.:||.||..|:|||.:...:||:||:|||..:|.:|
Mouse   426 GLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	204/455 (45%)
Slc1a1	NP_033225.1	SDF	51..464	CDD:278787	195/424 (46%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	330..332		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	410..414		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm42841
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730