DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eaat2 and slc1a7a

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001278273.1	Gene:	slc1a7a / 100170783	ZFINID:	ZDB-GENE-061009-24	Length:	582	Species:	Danio rerio

Alignment Length:	505	Identity:	187/505 - (37%)
Similarity:	305/505 - (60%)	Gaps:	33/505 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIAGSASL 112
            :|.:|::::..|::|.:||..||..:|....:....:||||.||:||::|||||:|||::|.|:|
Zfish    16 QNGLLILSVLAVVIGCLLGFFLRSKHLSEQEVKYFQFPGELLMRMLKMLILPLVVSSLMSGLAAL 80

  Fly   113 NAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSLLDLGR 177
            :||.:.::.:.|:.|:..|:|....:||.:|::||||.. ....|...:.:..::..|:||||.|
Zfish    81 DAKCSSRLGIMTISYYLWTTFVAVVVGIVMVIIIHPGGA-AQKEDSEDSGKAIMSSADALLDLIR 144

  Fly   178 NVFPDNLFQASIQQAHT----VYLPKPSILHVFNETMNDTL-------ASGSEAQRLSEDLTEDV 231
            |:||.||.||:.||..|    :..|||:|.....||....:       .:|::.|..|.|||..
Zfish   145 NMFPANLVQATFQQYRTRSIPIMKPKPTISQDILETTTKRVFIYGIQDDNGTDIQNFSLDLTPP- 208

  Fly   232 VLVRDIQYRS------GTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWL 290
               .|:.:|:      |.|.||||.|....|..||.:|..|..:|:|..::.|.::|:|..|:|.
Zfish   209 ---PDVVFRTLPGTSEGMNVLGIVIFSATMGIMLGRMGPNGSALVNFCQSLNEAVLKIVAIVIWY 270

  Fly   291 TPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLI 355
            .|.||..::|||||.:.|...:..:|.::.:||.:|:.::...::.::||.:.:::|..:..|::
Zfish   271 FPFGIVFLVAGKILEMDDPSAMGKKLGFYAITVVMGLVLHGLFILPSMYFFITKKSPIVYIRGIL 335

  Fly   356 QAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSG 420
            ||:|.:.||:|::|.|||||:|:.|...:|.||.|||||:|..|||||||||.|||:|||||::.
Zfish   336 QALLISLATSSSSATLPITFKCLLENNHIDRRIIRFVLPVGATINMDGTALYEAVAAIFIAQVNN 400

  Fly   421 MVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNN 485
            ..|.||:::|:.:|:||||:.:|.:|.|.||.:::|||::..|..|:||:.||||.:||.||..|
Zfish   401 YELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMVN 465

  Fly   486 MLGDCYTAAVVEELSRKE-----------LMALDAASVNYQDMPAGTPNG 524
            ::||.....::..:.||:           |:......::.|.|.:...||
Zfish   466 VMGDALATGIMAHICRKDFVKEGEEVRIPLICETKPMISIQQMMSYQKNG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	179/461 (39%)
slc1a7a	NP_001278273.1	SDF	19..479	CDD:278787	179/464 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm25669
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830