Protein Alignment Eaat2 and slc1a5

DIOPT Version :10

• Sequence 1: NP_001162844.1
• Gene: Eaat2 / 33247
• FlyBaseID: FBgn0026438
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_001177684.1
• Gene: slc1a5 / 100002129
• ZFINID: ZDB-GENE-070501-4
• Length: 539
• Species: Danio rerio
• Alignment Length: 513
• Identity: 181/513 - (35%)
• Similarity: 303/513 - (59%)
• Gaps: 39/513 - (7%)

  Fly    24 ELPPKTTECSD---APVELTG--YRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLIS 83
            ::||.....|:   :..|.|.  .:|::..||::::|:|.|::||::||.:|...|....|:...
Zfish    21 DVPPHANGLSEHRRSEPESTAQKVKRFVLANLLVILTVSAVIVGVLIGLGVRNAGLSRTQIIYFG 85

  Fly    84 YPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHP 148
            :||||.:|:||::|:|||:.||::|:||::.|..||:....:::|..|:...:|:|:.:..:|||
Zfish    86 FPGELLIRLLKMIIIPLVVCSLVSGAASIDPKALGKLGGWAMLFFLVTTLIASAIGVIMAFIIHP 150

  Fly   149 GNPD----LHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNET 209
            |:.|    ..||.|.|:...|.:::||.|||.||:||.||..|:.|...|.|          ...
Zfish   151 GSSDGKMSQLNAQDDSSVPEAKDVIDSFLDLIRNIFPSNLVAAAFQSYATGY----------KFV 205

  Fly   210 MNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFA 274
            .|||.:|         .|.|.|.:..|:   .|.|.||::.|.:.||..|..:|::|.:::.||.
Zfish   206 KNDTNSS---------VLLEKVPVGTDV---DGMNILGLIVFAMAFGVALRKLGEEGVILMKFFN 258

  Fly   275 AIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIY 339
            :..|..|.:|:.:||..|:||..::|.||:.:.|:.|:.:.|..:|....||..|:..:|:..||
Zfish   259 SFNEATMVLVSWIMWYAPLGIMFLVAAKIVEMEDVSLLFTSLGKYIACCVIGHAIHGLLVLPLIY 323

  Fly   340 FVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGT 404
            |::.|:||:.|..||:.|:.|||.|:|::|.||:..:|:.|...|...|:||:||||..:||||.
Zfish   324 FIITRKNPYTFLLGLVTALATAFGTSSSSATLPLMMKCVEENNGVSKHISRFILPIGATVNMDGA 388

  Fly   405 ALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTL 469
            |.:..||::||||::|:.|.|.:::|:|:|:||:|:.:|.:|:..::.|.::|.::..|..|::|
Zfish   389 ACFQCVAAVFIAQLNGIPLNFVQVITILVTATASSVGAAGIPAGGVLTLAIILESVGLPTNDLSL 453

  Fly   470 LFAVDWFVDRIRTTNNMLGDCYTAAVVEEL-----SRKELMALDAASVNYQDMPAGTP 522
            :.||||.|||..|..|:.||.|.|.:::.|     ::.|...||...|...|   .||
Zfish   454 ILAVDWLVDRTCTVINVEGDAYGAGLLQYLVDRHPNKNEEEELDKIRVEEDD---ATP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..499	CDD:425646	165/451 (37%)
slc1a5	NP_001177684.1	GltP	53..498	CDD:440912	168/466 (36%)