DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eaat2 and slc1a5

DIOPT Version :9

Sequence 1:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001177684.1	Gene:	slc1a5 / 100002129	ZFINID:	ZDB-GENE-070501-4	Length:	539	Species:	Danio rerio

Alignment Length:	513	Identity:	181/513 - (35%)
Similarity:	303/513 - (59%)	Gaps:	39/513 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ELPPKTTECSD---APVELTG--YRRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLIS 83
            ::||.....|:   :..|.|.  .:|::..||::::|:|.|::||::||.:|...|....|:...
Zfish    21 DVPPHANGLSEHRRSEPESTAQKVKRFVLANLLVILTVSAVIVGVLIGLGVRNAGLSRTQIIYFG 85

  Fly    84 YPGELFMRVLKLMILPLVISSLIAGSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHP 148
            :||||.:|:||::|:|||:.||::|:||::.|..||:....:::|..|:...:|:|:.:..:|||
Zfish    86 FPGELLIRLLKMIIIPLVVCSLVSGAASIDPKALGKLGGWAMLFFLVTTLIASAIGVIMAFIIHP 150

  Fly   149 GNPD----LHNADDRSTDRRAVNLLDSLLDLGRNVFPDNLFQASIQQAHTVYLPKPSILHVFNET 209
            |:.|    ..||.|.|:...|.:::||.|||.||:||.||..|:.|...|.|          ...
Zfish   151 GSSDGKMSQLNAQDDSSVPEAKDVIDSFLDLIRNIFPSNLVAAAFQSYATGY----------KFV 205

  Fly   210 MNDTLASGSEAQRLSEDLTEDVVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFA 274
            .|||.:|         .|.|.|.:..|:   .|.|.||::.|.:.||..|..:|::|.:::.||.
Zfish   206 KNDTNSS---------VLLEKVPVGTDV---DGMNILGLIVFAMAFGVALRKLGEEGVILMKFFN 258

  Fly   275 AIFEVIMKMVTCVMWLTPVGISSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIY 339
            :..|..|.:|:.:||..|:||..::|.||:.:.|:.|:.:.|..:|....||..|:..:|:..||
Zfish   259 SFNEATMVLVSWIMWYAPLGIMFLVAAKIVEMEDVSLLFTSLGKYIACCVIGHAIHGLLVLPLIY 323

  Fly   340 FVVVRRNPFKFYAGLIQAMLTAFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGT 404
            |::.|:||:.|..||:.|:.|||.|:|::|.||:..:|:.|...|...|:||:||||..:||||.
Zfish   324 FIITRKNPYTFLLGLVTALATAFGTSSSSATLPLMMKCVEENNGVSKHISRFILPIGATVNMDGA 388

  Fly   405 ALYIAVASIFIAQMSGMVLGFGELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTL 469
            |.:..||::||||::|:.|.|.:::|:|:|:||:|:.:|.:|:..::.|.::|.::..|..|::|
Zfish   389 ACFQCVAAVFIAQLNGIPLNFVQVITILVTATASSVGAAGIPAGGVLTLAIILESVGLPTNDLSL 453

  Fly   470 LFAVDWFVDRIRTTNNMLGDCYTAAVVEEL-----SRKELMALDAASVNYQDMPAGTP 522
            :.||||.|||..|..|:.||.|.|.:::.|     ::.|...||...|...|   .||
Zfish   454 ILAVDWLVDRTCTVINVEGDAYGAGLLQYLVDRHPNKNEEEELDKIRVEEDD---ATP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	165/448 (37%)
slc1a5	NP_001177684.1	SDF	53..480	CDD:278787	165/448 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830