DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb19

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444374.2	Gene:	Pcdhb19 / 93890	MGIID:	2136757	Length:	801	Species:	Mus musculus

Alignment Length:	806	Identity:	218/806 - (27%)
Similarity:	334/806 - (41%)	Gaps:	176/806 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIG-YIGDFG-GIDSGPPYIIVAEAGVETD- 122
            :||..|.||.|||.|    ...:|.|.|.:.....:| .:.|.| .:|.    :...||.|.:.
Mouse    14 VLLLFVFLGMSQAHS----EAGRLSVVEEMLSGALVGNLVKDLGLQVDE----LSAREAQVASSD 70

  Fly   123 ----LAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLVTVKDENDNAPTF 174
                |.::..||::.....||||.....:         |:..||  :.::..:.|.|.|||:|.|
Mouse    71 NKLPLQLNINTGDLLLSEPLDREELCGSTEPCVLHFQVLLKNPL--KILQAELQVTDVNDNSPVF 133

  Fly   175 PQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQ 239
            .:..|.:|.|||:|......|..|.|||:.....:.|.|   :.|..|.::.....||..|.:|.
Mouse   134 LEKEMVLEIPENSPVGAVFLLESAIDLDVGINAVKSYEI---SQNSHFHVTMRVNPDGRKYPELV 195

  Fly   240 ISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTS 304
            :...||.|......|::.||||||||..|...|.:.:.|:|||.|.|:...|..|||||:.:|:.
Mouse   196 LDKALDYEEQHELRLILTALDGGTPPRSGTALVRVEVIDINDNSPEFDHMFYEVTVPENSMLGSL 260

  Fly   305 VLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHG 369
            ::...|.|.|:..||.|.||.:....|..:.|.|:..:|.|.:...|||||.|.:.:::.|.|.|
Mouse   261 LITASAWDLDSGINGEVSYAFSHASEDIRKTFAINEHSGEIRLKGYLDFETTESYSIIIKATDRG 325

  Fly   370 EQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVN 434
              .|...:.|.|:|.|||||.|.   |.:|...||....:|:  ..|...|:.|.|| .|...:.
Mouse   326 --GLFGKSTVRIQVMDVNDNFPE---IIVSSFISPIPENTAE--TLVMIFSIRDKDS-GENGKMV 382

  Fly   435 VTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVND 499
            .|:..| ..|.|.:...:.|.:.....||||.::.|.:::..||.|||.|....:|.:::.|:||
Mouse   383 CTIPEG-LPFVLKSSIENYYHLETDGALDRESIAEYNITISVTDLGTPRLTTQHTIIVQVADIND 446

  Fly   500 NPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLIT 564
            |.|.|.|..|.....|...|...:..:.|.|.|.|.|:.:||||
Mouse   447 NAPAFTQTSYTMFFHENNSPALHIGTISATDSDAGSNAHITYSL--------------------- 490

  Fly   565 TRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRC 629

Mouse   491 ----------------------------------------------------------------- 490

  Fly   630 ILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRG- 693
               :||.|....::::::              :.:.:|::.....||:|...::||.|.|||||
Mouse   491 ---MSAQDLQMALSSLIS--------------INADNGQLFALRALDYEVLQAFEFQVGATDRGS 538

  Fly   694 -GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP--------------IVAV 742
             .||:.|::::.:.|.|||.| |.||              .|.:|.|              :..|
Mouse   539 PALSSQALVRVVVLDDNDNAPFVLYP--------------MQNASAPCTELLPRAAEPGYLVTKV 589

  Fly   743 VATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRS 807
            ||.|.|.|....:|::::...|.|:|.:....||:...|  :||.|..|.|.|.:...|.|:...
Mouse   590 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLSERDAPKHRLLLLVKDNGDPPR 652

  Fly   808 NADAVVFLSIIDAMQRP--PIFEKAR 831
            :|...:.:.::|...:|  |:.|.||
Mouse   653 SASVTLHVLVVDGFSQPYLPLPEVAR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	18/74 (24%)
		Cadherin_repeat	178..282	CDD:206637	35/103 (34%)
		Cadherin_repeat	291..389	CDD:206637	36/97 (37%)
		Cadherin_repeat	406..500	CDD:206637	26/93 (28%)
		Cadherin_repeat	509..607	CDD:206637	12/97 (12%)
		Cadherin_repeat	616..711	CDD:206637	20/96 (21%)
		Cadherin_repeat	719..820	CDD:206637	25/114 (22%)
		Cadherin_repeat	832..927	CDD:206637	218/806 (27%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb19	NP_444374.2	Cadherin_2	32..112	CDD:285466	18/83 (22%)
		Cadherin_repeat	137..238	CDD:206637	35/103 (34%)
		Cadherin_repeat	247..343	CDD:206637	36/97 (37%)
		Cadherin_repeat	356..447	CDD:206637	26/94 (28%)
		Cadherin_repeat	455..557	CDD:206637	32/204 (16%)
		Cadherin_repeat	576..664	CDD:206637	22/89 (25%)
		Cadherin_C_2	687..769	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000