DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb18

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444373.1	Gene:	Pcdhb18 / 93889	MGIID:	2136756	Length:	792	Species:	Mus musculus

Alignment Length:	835	Identity:	213/835 - (25%)
Similarity:	328/835 - (39%)	Gaps:	218/835 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LILLAIVLLGSSQAASHD--QERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYIIVAEAGVET- 121
            |.||..:.|..|:...:.  :|.||...| ..:|.|..:|               :.|.|...|
Mouse    17 LFLLGGLCLAGSELGRYSVTEETERGSFV-ANLAKDLGLG---------------VEALAAKRTR 65

  Fly   122 --------DLAIDRATGEIRTKVKLDRETRAS-------YSLVAIPLSGRNIRVLVTVKDENDNA 171
                    .|.:|..||::.|..|||||....       |..:.:....:..|..:.:.|.||::
Mouse    66 VVCDDNKQHLFLDSHTGDLLTNEKLDREKLCGPTEPCMLYFQILMDNPFQIYRAELRILDINDHS 130

  Fly   172 PTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYL 236
            |.|....|.::..|||.......|..|:|.|......|.|.|   :.|..|.::.|...:|::|.
Mouse   131 PIFQDKKMILKILENTAVGTTFRLERAQDSDGGRNGIQNYTI---SPNTFFHITVHNSDEGMIYP 192

  Fly   237 DLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATV 301
            :|.:...||.|..|.:||.:.|||||:||..|..|::|.:.|:|||.|.|.|..|....|||:.:
Mouse   193 ELVLDKALDWEGQPEFSLTLTALDGGSPPRSGTATIHILVLDINDNAPQFPQELYEIQAPENSPI 257

  Fly   302 GTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAK 366
            |..|::|...|.|:..|..:.|:......|....|:|:|.:|.|.:...||:|..:.::|.|.|.
Mouse   258 GLVVIKVTGEDVDSGVNAEISYSFFDASEDIRATFQINPFSGEITLKALLDYEFIKSYKLNVQAV 322

  Fly   367 DHGEQPLETTAFVSIRVTDVNDNQP-----------------TINVIFLSDDASPKISESAQPGE 414
            |.|  .|.....|.:||.|||||.|                 |:..:|..:|     .:|.:.|:
Mouse   323 DGG--GLSARCTVLVRVLDVNDNAPELIMSSLVNEVVENSPETVLAVFRIND-----RDSGENGK 380

  Fly   415 FVARISVHDPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDK 479
            .|..|..:.|                   |.|....::.|:::....||||..:.|.:::..:|.
Mouse   381 MVCHIQENLP-------------------FLLKPSVDNFYILMTEGALDRESRAEYNITITVSDL 426

  Fly   480 GTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLA 544
            |||.|....:|.::::|:|||.|.|.|..|...|.|...|...:..:.|.|.|.|.|:.:||||.
Mouse   427 GTPRLTTQHTIRVQVSDINDNAPAFNQTSYTLFVRENNSPAMHIGTISATDSDAGSNAHITYSLL 491

  Fly   545 ETPETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEP 609
            .|.:                                          |..|.|.||:|:
Mouse   492 PTQD------------------------------------------LQMTLTSLVSIN------- 507

  Fly   610 IFDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGE 674
                       |:|                                           |::.....
Mouse   508 -----------ADN-------------------------------------------GQLFAIKA 518

  Fly   675 LDFERRSSYEFPVLATDRGG--LSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASS 736
            ||:|...::||.|.|||||.  ||:.|::::.:.|.|||.| |.||              .|.:|
Mouse   519 LDYEALQAFEFHVGATDRGSPELSSQALVRVVVLDDNDNAPFVLYP--------------MQNAS 569

  Fly   737 TP--------------IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSV 787
            .|              :..|||.|.|.|....:|::::...|.|:|.:....||:...|  :||.
Mouse   570 APYTELLPRTAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLSE 632

  Fly   788 RTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRP--PIFEKARYNYYVKEDI 840
            |..|.|.|.:...|.|:...:|...:.:.::|...:|  |:.|.|......:||:
Mouse   633 RDVPKHRLLLLVKDNGDPPRSASVTLQVLLVDGFSQPYLPLPEVAHNPTQGEEDV 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	18/76 (24%)
		Cadherin_repeat	178..282	CDD:206637	35/103 (34%)
		Cadherin_repeat	291..389	CDD:206637	32/97 (33%)
		Cadherin_repeat	406..500	CDD:206637	21/93 (23%)
		Cadherin_repeat	509..607	CDD:206637	20/97 (21%)
		Cadherin_repeat	616..711	CDD:206637	19/96 (20%)
		Cadherin_repeat	719..820	CDD:206637	25/114 (22%)
		Cadherin_repeat	832..927	CDD:206637	2/9 (22%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb18	NP_444373.1	Cadherin_2	32..112	CDD:285466	21/95 (22%)
		Cadherin_repeat	140..238	CDD:206637	34/100 (34%)
		Cadherin_repeat	247..343	CDD:206637	32/97 (33%)
		Cadherin_repeat	355..447	CDD:206637	24/115 (21%)
		Cadherin_repeat	455..557	CDD:206637	39/204 (19%)
		Cadherin_repeat	571..664	CDD:206637	23/94 (24%)
		Cadherin_C_2	688..771	CDD:293101	213/835 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000