DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb17

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444372.2	Gene:	Pcdhb17 / 93888	MGIID:	2136754	Length:	799	Species:	Mus musculus

Alignment Length:	821	Identity:	221/821 - (26%)
Similarity:	333/821 - (40%)	Gaps:	206/821 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ILLAIVLLGSSQAA------SHDQERERKLEVFEGVAVDYQIGYIGDFG---GID----SGPPYI 112
            :|...|||..|.|.      |.::|.||.             .::.:.|   |:|    |.....
Mouse    14 VLAFFVLLHVSGAGAELGPYSIEEETERG-------------SFVANLGKDLGVDLAEISNRRAR 65

  Fly   113 IVAEAGVETDLAIDRATGEIRTKVKLDRETRAS---------YSLVAIPLS--GRNIRVLVTVKD 166
            |:::...| .|.::..:|::....|||||....         ..|:..||.  ...:||:    |
Mouse    66 IISQENKE-HLQLNLQSGDLLINEKLDREELCGPIEPCVLHFQVLMENPLEVFQAELRVM----D 125

  Fly   167 ENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERD 231
            .||.:|.|.:..|.:...||:.......|..|.|.|:...|.|.|.:.|   |..|.:.:....|
Mouse   126 INDYSPVFSEREMILRILENSALGDTFPLNNALDSDVAINNIQTYRLSS---NSHFLVVTRNRSD 187

  Fly   232 GVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVP 296
            |..|.:|.:...||||..|...|.:.|||||.||..|...|.|.:.|:|||.|.|.|..|...:|
Mouse   188 GRKYPELVLEKELDREEEPELRLTLTALDGGAPPRSGTAQVLIEVVDINDNAPKFQQPTYRVQIP 252

  Fly   297 ENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHEL 361
            ||:..|:.||.|.|:|.|:.:.|.|.||:::...|..:...::|.||.|.:.|.:||||...:|:
Mouse   253 ENSPTGSLVLTVSANDLDSGDYGKVLYALSQPSEDISKTLEVNPVTGEIRLRKEVDFETIPSYEV 317

  Fly   362 VVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDS 426
            .:.|.|.|  .|.....:.::|.|||||.|.   :.||...|| :.|:: |.|.||..||.||||
Mouse   318 DIKATDGG--GLSGKCTLLLKVVDVNDNAPE---VMLSALTSP-VPENS-PDEVVAVFSVKDPDS 375

  Fly   427 KTEYANVNVTLNG-------GDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPL 484
                ||     ||       .|..|.|.:...:.|.::....||||....|.:::..:|.|||.|
Mouse   376 ----AN-----NGKMIASIEEDLPFLLKSSGKNFYTLVTKRALDREEREKYNITITVSDLGTPRL 431

  Fly   485 HASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPET 549
            ....:|.::::|.|||.|.|.|..|...|.|...|...:..:.|.|.|.|.||.::|||..
Mouse   432 TTQHTITVQVSDTNDNAPAFNQTSYTLFVRENNSPAMHIGTISATDSDAGSNSHISYSLLP---- 492

  Fly   550 HAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQS 614
                             ||
Mouse   493 -----------------SH---------------------------------------------- 494

  Fly   615 FYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFER 679
                                  ||...::::::              :.:.:|::.....||:|.
Mouse   495 ----------------------DPQLALDSLIS--------------INADNGQLFALRALDYEA 523

  Fly   680 RSSYEFPVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP--- 738
            ..::||.|.|.|:|  .||:.|::::.:.|.|||.| |.||              .|.||.|
Mouse   524 LQAFEFHVGAIDQGSPALSSQALVRVVVLDDNDNAPFVLYP--------------MQNSSAPCTE 574

  Fly   739 -----------IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPM 792
                       :..|||.|.|.|....:|::::...|.|:|.:....||:...|  :||.|..|.
Mouse   575 LLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLSERDVPK 637

  Fly   793 HMLNISATDGGNLRSNADAVVFLSIIDAMQRP--PIFEKAR 831
            |.|.:...|.|:...:|...:.:.::|...:|  |:.|.||
Mouse   638 HRLVLLVKDNGDPPRSASVTLHVLVVDGFSQPYLPLPEVAR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	17/71 (24%)
		Cadherin_repeat	178..282	CDD:206637	35/103 (34%)
		Cadherin_repeat	291..389	CDD:206637	34/97 (35%)
		Cadherin_repeat	406..500	CDD:206637	32/100 (32%)
		Cadherin_repeat	509..607	CDD:206637	15/97 (15%)
		Cadherin_repeat	616..711	CDD:206637	17/96 (18%)
		Cadherin_repeat	719..820	CDD:206637	26/114 (23%)
		Cadherin_repeat	832..927	CDD:206637	221/821 (27%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb17	NP_444372.2	Cadherin_2	33..112	CDD:285466	18/92 (20%)
		Cadherin_repeat	137..238	CDD:206637	35/103 (34%)
		Cadherin_repeat	246..343	CDD:206637	34/98 (35%)
		Cadherin_repeat	356..447	CDD:206637	32/100 (32%)
		Cadherin_repeat	455..557	CDD:206637	32/204 (16%)
		Cadherin_repeat	576..664	CDD:206637	22/89 (25%)
		Cadherin_C_2	687..770	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910