DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhb15

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444370.1	Gene:	Pcdhb15 / 93886	MGIID:	2136750	Length:	786	Species:	Mus musculus

Alignment Length:	686	Identity:	193/686 - (28%)
Similarity:	304/686 - (44%)	Gaps:	103/686 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 SSQASSTPIVAVVATDPDYGNF------------GQVS---YRIVAGNEAGIFRIDRSTGEIFV- 779
            :|.||:..:...||.:.:.|.|            |::|   .|||:........:...|||:.:
Mouse    23 ASWASAEQLQYSVAEETERGTFLANLAKDLGLGLGELSAREARIVSDQNTRFLLLSPLTGELILN 87

  Fly   780 -----------VRPDMLSVR---TQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKA 830
                       ..|.:|:.:   .:|..:...:                |.|.|.....|:|...
Mouse    88 EKLDREELCGPTEPCVLTFQLLLERPFQIYRAA----------------LHIKDINDNSPVFLDK 136

  Fly   831 RYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSG-------NIRIAK 888
            .....:.|....|..:....|...||...|...|:|   .|:.||.|..:.|       .:.:.|
Mouse   137 EILLKISESTTPGATLLLERAQDADVGTNSLSNYTI---SPNDYFHIHVHDGGEGPIIPELVLDK 198

  Fly   889 PLDHEAKSQVLLNIQA-TLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYA 952
            .||.|...:..|.:.| ..|.||..|...|.|.|.|:|||:|:|..|:.::..||:..:|:.:.|
Mouse   199 MLDREEIPEFTLTLTALDGGSPPRSGTALVQILVLDINDNSPQFVQSLYKVQSPENTPVGSLVVA 263

  Fly   953 AHAHDKDSGSSGQVTYSLVKESGKGL--FAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPS 1015
            ..|.|.|:||.||:.|:....:.:.|  |.|::.||.|.|.:.|:||:.|.:::.:.|.|||  .
Mouse   264 VSARDLDTGSYGQIDYTFFYATERILQTFQINSTSGELYLKRELNYEAIQTYSITIQARDGG--G 326

  Fly  1016 LSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD--- 1077
            ||....::|:|.|||||||.|.....:..:.|: |....:......|.|:|||.:....|.:
Mouse   327 LSGKCAVVVEVMDVNDNPPEFLLSSLNSPIPEN-SQETVVAVFKIRDRDSGNNGKTLCSIANDLP 390

  Fly  1078 ----AGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTR 1138
                ..|:|....::..                   |||||:...|.:|:..||.|.|....:..
Mouse   391 FVLKPSVENFYTLVTEK-------------------PLDRESNTEYNITITVTDMGIPRLTTQHT 436

  Fly  1139 VIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSL-------LPIN 1196
            :.|:|.|.|||.|.|.::.|...:.||......:|.::|:|.|.|.||.|.|||       |.::
Mouse   437 ITVQVSDINDNAPTFTQTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLRLPHDPQLALD 501

  Fly  1197 SSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQE 1261
            |...::...|::.....||.|..:.::..|.|.|||:|..|::..||:.:.|.|||||.:..|.:
Mouse   502 SLISINADNGQLFALRALDYEALQAFEFHVGAIDQGSPALSSQALVRVVILDDNDNAPFVLYPMQ 566

  Fly  1262 DVVSVREE-----QPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRV 1321
            :..:...|     ..||..|.:|.|||||.||||.:::.::|..:.   ||||:...:|.:||..
Mouse   567 NASAPYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEP---GLFSVWAHNGEVRTTR 628

  Fly  1322 VLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLD 1357
            :|...:...::|.|...|.|.|||.....|.|.::|
Mouse   629 LLSERDVPKHKLLVVVKDNGEPPRSASVTLHVLLVD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637	20/118 (17%)
		Cadherin_repeat	832..927	CDD:206637	28/102 (27%)
		Cadherin_repeat	937..1032	CDD:206637	34/96 (35%)
		Cadherin_repeat	1040..1149	CDD:206637	25/115 (22%)
		Cadherin_repeat	1158..1252	CDD:206637	31/100 (31%)
		Cadherin_repeat	1263..1361	CDD:206637	33/100 (33%)
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb15	NP_444370.1	Cadherin_2	30..111	CDD:285466	14/80 (18%)
		Cadherin_repeat	140..238	CDD:206637	28/100 (28%)
		Cadherin_repeat	247..343	CDD:206637	34/97 (35%)
		Cadherin_repeat	356..447	CDD:206637	25/110 (23%)
		Cadherin_repeat	455..557	CDD:206637	31/101 (31%)
		Cadherin_repeat	571..664	CDD:206637	32/95 (34%)
		Cadherin_C_2	686..769	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910