DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb12

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444367.1	Gene:	Pcdhb12 / 93883	MGIID:	2136747	Length:	789	Species:	Mus musculus

Alignment Length:	877	Identity:	247/877 - (28%)
Similarity:	392/877 - (44%)	Gaps:	179/877 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   729 KASSQA---------SSTPIVAVVATD-----PDYGNFG-QVSYRIVAGNEAGIFRIDRSTGEIF 778
            |:.|:|         .|..:||.||.|     .:....| |:.||   ||:. :.::|..||.:|
Mouse    18 KSDSEAIRYSMPEEKESGYLVANVAKDLGLRVEELATRGAQIHYR---GNKE-LLQMDAETGNLF 78

  Fly   779 V---VRPDMLSVRTQP--MHMLNISATDGGNLRSNADAVVF----LSIIDAMQRPPIFEKARYNY 834
            :   :..:.|...|:|  :|...|.          .:.|.|    |.:.|.....|.|.......
Mouse    79 LKEKLDREALCGATEPCVLHFQIIL----------ENPVQFFQTELQLTDINDHSPEFSDTEMLL 133

  Fly   835 YVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGN-------IRIAKPLDH 892
            .:.|:...|||.....|...|:...:...|::   :|:.:|.:.|.|.:       :.:.:.||.
Mouse   134 TIPENAQPGTVFPLKAAHDSDIGSNAVQNYTV---NPNIHFHVVTLSRSDGRKYPELVLDRALDR 195

  Fly   893 EAKSQVLLNIQA-TLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAH 956
            |.:.::.|.:.| ..|.||..|.|:|:|||.|:|||||:|..|:..:.|||::.|.|.:....|.
Mouse   196 EEQPELTLTLTALDGGSPPRSGTTEVHIEVVDINDNAPQFIQSLYEVQVPENSPLNALVVMVSAT 260

  Fly   957 DKDSGSSGQVTYSLVKESGKGL---FAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLST 1018
            |.|:|..|.|.|||.:  |.||   |.||..:|.:.|::.||:|.|..:|:.:.|||||  .||.
Mouse   261 DLDAGIYGNVAYSLFQ--GDGLSQPFVIDKITGEIRLTKELDFEVSHHYTIEIAATDGG--GLSG 321

  Fly  1019 NLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNV 1083
            ..|:::.|.|||||.|.....:.:|.|.|: |....:...:.||.|:|:|.||        |.::
Mouse   322 KCTVVIQVLDVNDNAPELAIRKLTVPVPEN-SAETVVAVFSVSDSDSGDNGRI--------VCSI 377

  Fly  1084 TNSISSSDVSQHFGI---FPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLD 1145
            .|:|.       |.:   |.|...:....|||||:|..|.:|:...|.|||....:..:.|:|.|
Mouse   378 QNNIP-------FLLKPTFENYYTLVTEGPLDRESRAEYNITITVWDLGTPRLTTQHTITVQVAD 435

  Fly  1146 ANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLP-------INSSFQVHP 1203
            .|||.|.|.::.|...::||......:|.::|:|.|.|.||.|.|||||       :.|...::.
Mouse   436 INDNAPAFTQTSYTLFVQENNSPALHIGTISATDSDSGSNAHITYSLLPPHDSQLALASLVSINS 500

  Fly  1204 VTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVRE 1268
            ..|::.....:|.|:.:.::|.|:|.|.|:|..|::..||:.|.|.|||:|.:..|.::..:...
Mouse   501 DNGQLFALRAMDYEMLQAFELHVDATDGGSPALSSQALVRVVVLDDNDNSPFVLYPMQNASAPCT 565

  Fly  1269 E-----QPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEER 1328
            |     ..||..:.:|.|||||.||||.:::.::|..:.   ||||:...:|.:||..:|...:.
Mouse   566 ELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEP---GLFSVWAHNGEVRTTRLLSERDA 627

  Fly  1329 SIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERP 1393
            ..::|.:...|.|:|||.....|.|.|:|                           |...|....
Mouse   628 PKHKLLLLVKDNGDPPRSASVTLHVLVVD---------------------------GFSQPYLPL 665

  Fly  1394 ADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDT 1458
            .:|.|:|.::.: |:...|                      ||||.   ..|.|.|.|.:...
Mouse   666 PEVARDSTQDDY-DVLTLY----------------------LVVAL---ASVSSLFLLSVLLF-- 702

  Fly  1459 TASNNPQSSAITVKI----EVADVND-NAPE--WPQDPIDLQVSEATPVGTIIHNF---TATDAD 1513
                      :.|::    ..|.:.| :.||  :|...:|  ||.|   ||:..::   ...:..
Mouse   703 ----------VGVRLCRRARAASLGDYSVPEGHFPSHLVD--VSRA---GTLSQSYQYEVCLNGG 752

  Fly  1514 TGTNGDLQYRLIR-YFPQL-----NESQEQAM 1539
            ||||   ::..:: .||.|     .|.:|.|:
Mouse   753 TGTN---EFNFLKPLFPILPTQAAAEERENAV 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637	27/114 (24%)
		Cadherin_repeat	832..927	CDD:206637	27/102 (26%)
		Cadherin_repeat	937..1032	CDD:206637	39/97 (40%)
		Cadherin_repeat	1040..1149	CDD:206637	33/111 (30%)
		Cadherin_repeat	1158..1252	CDD:206637	32/100 (32%)
		Cadherin_repeat	1263..1361	CDD:206637	32/102 (31%)
		Cadherin_repeat	1369..1481	CDD:206637	18/116 (16%)
		Cadherin_repeat	1489..1598	CDD:206637	16/60 (27%)
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb12	NP_444367.1	Cadherin_2	24..105	CDD:285466	21/94 (22%)
		Cadherin_repeat	133..231	CDD:206637	27/100 (27%)
		Cadherin_repeat	240..335	CDD:206637	39/98 (40%)
		Cadherin_repeat	345..439	CDD:206637	33/109 (30%)
		Cadherin_repeat	447..549	CDD:206637	32/101 (32%)
		Cadherin_repeat	568..656	CDD:206637	30/90 (33%)
		Cadherin_C_2	680..762	CDD:293101	25/126 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000