DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb8

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444363.1	Gene:	Pcdhb8 / 93879	MGIID:	2136742	Length:	779	Species:	Mus musculus

Alignment Length:	827	Identity:	227/827 - (27%)
Similarity:	332/827 - (40%)	Gaps:	201/827 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LILLAIVLL---GSSQAASHDQERERKLEVFEGVAVDYQIGYI-----GDFGGIDSGPPYIIVAE 116
            :|.|||:||   .||:|.|:....|.            :.||:     .|.|        :.|.|
Mouse    14 VIFLAILLLLWEASSEAISYSMPEET------------ESGYLVANLAQDLG--------LRVGE 58

  Fly   117 A----------GVETDLAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLV 162
            .          |.:..|.:|...|.:..|.|.|||.....:         ::..|:......:..
Mouse    59 LTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTDLQF 123

  Fly   163 TVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSH 227
            |  |.||:.|.||.|.|.::..|.........|..|:|.|:.....|.|. ||.|::  |.:.:.
Mouse   124 T--DINDHFPEFPDTEMLLKIQEIAQPGTVFPLKAAQDPDIGSNAVQNYT-VSPNLH--FHVVTL 183

  Fly   228 RERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYF 292
            ...|...|.:|.:...||||..|..:|::.|||||.||..|..||.|.:.|:|||.|.|.||.|.
Mouse   184 SRSDDRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDINDNAPQFLQSLYA 248

  Fly   293 ATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKE 357
            ..||||:.:...|:.|.|.|.||..:|.|.|:: .:.....|.|.||..||.|.:..|||||...
Mouse   249 VEVPENSPLNALVVTVSARDLDAGIHGNVAYSL-FQGGGGPQPFVIDEITGEIRLKGALDFEATS 312

  Fly   358 LHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVH 422
            .:.:.:||.|.|  .|.....|:|:|.|||||.|.:.:..|:.    .|.|:| |...||..||.
Mouse   313 YYTMEIVATDSG--GLSGKCTVAIQVLDVNDNAPKLTISSLTS----SIPENA-PEAVVAVFSVS 370

  Fly   423 DPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHAS 487
            ||||......|....||..  |.|.....:.|.::...|||||..:.|.:::..:|.|||.|...
Mouse   371 DPDSGDNGRMVCSIQNGLP--FLLKPTFKNFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQ 433

  Fly   488 KSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQ 552
            .:|.::::|:|||.|.|.|..|...|.|...|...:..:.|.|.|.|.|..:.|||
Mouse   434 HTITVQVSDINDNAPAFTQTSYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSL--------- 489

  Fly   553 WFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN 617
                                               :||
Mouse   490 -----------------------------------LPP--------------------------- 492

  Fly   618 VSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSS 682
                              .|...|:.::::              :.|.:|::.....||:|...:
Mouse   493 ------------------HDQQLGLASLIS--------------INSDNGQLFALRALDYEALQA 525

  Fly   683 YEFPVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP------ 738
            :||.|.|||||  .||:.|::::.:.|.|||.| |.||              .|.:|.|
Mouse   526 FEFHVGATDRGSPALSSEALVRVVVLDDNDNAPFVLYP--------------LQNASAPCTELLP 576

  Fly   739 --------IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHML 795
                    |..|||.|.|.|....:|::::...|.|:|.:....||:...|  :||.|..|.|.|
Mouse   577 RAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLSERDAPKHRL 639

  Fly   796 NISATDGGNLRSNADAVVFLSIIDAMQRP--PIFEKARYNYYVKEDI 840
            .:...|.|....:|..::.:.::|...:|  |:.|.| .|...:||:
Mouse   640 LLLVKDNGEPLRSASVMLQVLVVDGFSQPYLPLPEVA-LNPTQEEDM 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	16/79 (20%)
		Cadherin_repeat	178..282	CDD:206637	34/103 (33%)
		Cadherin_repeat	291..389	CDD:206637	37/97 (38%)
		Cadherin_repeat	406..500	CDD:206637	32/93 (34%)
		Cadherin_repeat	509..607	CDD:206637	14/97 (14%)
		Cadherin_repeat	616..711	CDD:206637	20/96 (21%)
		Cadherin_repeat	719..820	CDD:206637	26/114 (23%)
		Cadherin_repeat	832..927	CDD:206637	3/9 (33%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb8	NP_444363.1	Cadherin_2	31..112	CDD:285466	17/100 (17%)
		Cadherin_repeat	140..238	CDD:206637	33/100 (33%)
		Cadherin_repeat	247..342	CDD:206637	37/97 (38%)
		Cadherin_repeat	354..446	CDD:206637	32/94 (34%)
		Cadherin_repeat	454..556	CDD:206637	34/204 (17%)
		Cadherin_repeat	575..663	CDD:206637	23/89 (26%)
		Cadherin_C_2	686..766	CDD:293101	227/827 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000